Unveiling the Therapeutic Potential of Targeting RRM2 in Hepatocellular Carcinoma: An Integrated In Silico and In Vitro Study [0.03%]
靶向RRM2治疗肝细胞癌的潜在疗效：一项整合生物信息学和体外实验的研究
Lobna Ibrahim,Rania Hassan Mohamed,Mahmoud M Tolba et al.
Lobna Ibrahim et al.
Hepatocellular carcinoma (HCC) has attracted global and local interest, with alarming current and forecasted statistics. This is mainly due to its late-stage diagnosis, high recurrence rate and potential resistance to conventional therapies...
Genome-resolved metagenomics from short-read sequencing data in the era of artificial intelligence [0.03%]
人工智能时代的短读长基因组分辨率宏基因组学
Hajra Qayyum,Zaara Ishaq,Amjad Ali et al.
Hajra Qayyum et al.
Genome-resolved metagenomics is a computational method that enables researchers to reconstruct microbial genomes from a given sample directly. This process involves three major steps, i.e. (i) preprocessing of the reads (ii) metagenome asse...
Integrated muti-omics data and machine learning reveal CD151 as a key biomarker inducing chemoresistance in metabolic syndrome-related early-onset left-sided colorectal cancer [0.03%]
整合多组学数据和机器学习揭示CD151是诱导代谢综合征相关早期左侧结直肠癌化疗耐药的关键生物标志物
Yingdong Hou,Hubin Xia,Chenshan Xu et al.
Yingdong Hou et al.
Emerging evidence has suggested a potential pathological association between early-onset left-sided colorectal cancer (EOLCC) and metabolic syndrome (MetS). However, the underlying genetic and molecular mechanisms remain insufficiently eluc...
PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma [0.03%]
PIN1可作为肺腺癌预后和治疗标志物
Juncheng Yu,Xiao Lu,Dong Zhou et al.
Juncheng Yu et al.
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide, with limited response rates and resistance to targeted therapies and immunotherapies. Pin1, a phosphorylation-specific peptidyl-prolyl isomerase, has ...
BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potential [0.03%]
BIRC5在肝癌中的作用及调控机制研究：促进肿瘤生存和治疗潜力方面的角色揭示
Aya M Ayoub,Elham Abdel-Badiea Mahmoud,Rania Hassan Mohamed et al.
Aya M Ayoub et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide, with limited effective therapeutic options. Identifying novel targets is crucial for improving treatment strategies. In this study, we integrated...
Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation [0.03%]
整合网络毒理学、单细胞测序、空间转录组和分子模拟分析全氟和多氟烷基物质(PFAS)在乳腺癌中的潜在作用靶点及机制研究
Jiajun Li,Deqi Wang,Sihan Song et al.
Jiajun Li et al.
Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are persistent environmental contaminants linked to adverse health effects, including an increased risk of breast c...
Selenium deficiency is functionally linked with the molecular etiopathogenesis of necrotizing enterocolitis (NEC) [0.03%]
硒缺乏与坏死性小肠结肠炎(M NEC)分子发病机制功能相关性研究
Kubilay Gürünlüoğlu,Muhammed Dündar,Turgay Ünver et al.
Kubilay Gürünlüoğlu et al.
Necrotizing enterocolitis (NEC) is a severe and often catastrophic gastrointestinal emergency that predominantly affects neonates, especially those born prematurely, and is associated with high rates of morbidity and mortality. Despite its ...
A novel oncogene, leucine-rich repeat protein 1, mediates hypoxia-induced hepatocellular carcinoma progression [0.03%]
新颖的癌基因富含亮氨酸重复蛋白1介导缺氧诱导的肝细胞癌进展
Li Tao,Yixian Guo,Runkun Liu et al.
Li Tao et al.
The involvement of leucine rich repeats protein 1 (LRR1) in various biological processes has been established, but its specific role and potential mechanisms in hepatocellular carcinoma (HCC) remain unclear. The aim of this study was to exp...
Sharanya K Sritharan,Amar Harris Arifin,Shamala Salvamani et al.
Sharanya K Sritharan et al.
Long stress-induced non-coding transcript 5 (LSINCT5) is a long non-coding RNA (lncRNA) that has been demonstrated to exhibit oncogenic properties as its upregulation was found to be commonly associated with malignant clinicopathological fe...
An efficient hairy root system for validation of CRISPR/Cas system activities in cotton [0.03%]
一个高效的毛状根系统用于棉花中CRISPR/Cas系统活性验证
Manyu Zhang,Lili Zhou,Mahideen Afridi et al.
Manyu Zhang et al.
The hairy root induction system has been widely applied in studying gene expression and function in plant species due to its rapidity and efficiency. The hairy root system is an efficient tool for evaluating the activities of CRISPR/Cas sys...