Development of Calcium Signaling in Postsynaptic Neurons of the Medial Nucleus of the Trapezoid Body in the Mouse [0.03%]
小鼠脑干梯形核 medial 核内突触后神经元钙信号的发生发展
Tasmuna T Tanmy,Huimei Wang,Yong Lu
Tasmuna T Tanmy
Purpose: In the central nervous system, Ca2⁺ signaling plays a pivotal role in various cellular processes, including neuronal development and maturation. Disruption of Ca2⁺ homeostasis impairs auditory circuit formation...
A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants [0.03%]
内耳植入物中神经激活和串扰的生物物理模型：同时刺激耳蜗和前庭神经的见解
Björn Vey,Michael Handler,Rudolf Glueckert et al.
Björn Vey et al.
Purpose: Simultaneous hearing and balance restoration through combined cochlear-vestibular implants (CVIs) offers a promising treatment for patients with dual sensory deficits. However, the effects of electrical stimulati...
Single Intratympanic Injection of Proprietary Brain-Derived Neurotrophic Factor (OTO-413) in Subjects with Speech-in-Noise Hearing Impairment: a Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study [0.03%]
单侧耳内注射改良型神经生长因子（OTO-413）治疗言语对背景噪音分辨能力下降的受试者：一项随机、递增剂量和双盲安慰剂对照的一期和二期临床试验
Alan C Foster,Jeffery J Anderson,David R Moore et al.
Alan C Foster et al.
Purpose: To evaluate the safety and tolerability and exploratory efficacy of OTO-413, an intratympanic-administered, sustained release formulation of brain-derived neurotrophic factor (BDNF) in a thermoreversible gel, in ...
Longitudinal Audiological and Vestibular Follow-up in Adult Cancer Patients Receiving Platinum-Based Chemotherapy [0.03%]
铂类化疗的成人癌症患者的纵向听力和前庭功能随访研究
Heleen Van Der Biest,Sarah Verhulst,Hannah Keppler et al.
Heleen Van Der Biest et al.
Purpose: Platinum-based chemotherapy is widely used in cancer care but carries a substantial risk of cochleotoxicity and vestibulotoxicity. This study aimed to characterize early (3-month) and long-term (1-year) auditory ...
A Time-Domain Model for the Generation of Spontaneous Otoacoustic Emissions in Resonant Cavities [0.03%]
共振腔室自发性耳声发射的时间域模型生成
Hero P Wit
Hero P Wit
A long-standing question in hearing science is whether spontaneous otoacoustic emissions (SOAEs) arise from a specific active site on the basilar membrane-they have a local origin-or whether they derive from distributed active elements work...
Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models [0.03%]
用于评估衰老和自闭症动物模型中神经元变化的听觉脑干反应合成计算模型
Ben-Zheng Li,Shani Poleg,Matthew Ridenour et al.
Ben-Zheng Li et al.
Purpose: The auditory brainstem response (ABR) is a widely used objective electrophysiology measure for non-invasively assessing auditory function and neural activity in the auditory brainstem, but its ability to reflect ...
Mara Mills
Mara Mills
The history of hearing aids is rife with examples of deaf invention, "sonic skills," and other expertise on the parts of deaf and hard of hearing people-whether they were celebrated figures like Thomas Edison, forgotten deaf scientists and ...
Correction: A Structural Equation Approach to Characterizing Growth and Nonlinearity Underlying Distortion Product Otoacoustic Emissions [0.03%]
关于畸变产物耳声发射增长及非线性特征的结构方程修正模型研究
Shawn S Goodman,M Ehsan Khalili,Julia H Roemen et al.
Shawn S Goodman et al.
A Structural Equation Approach to Characterizing Growth and Nonlinearity Underlying Distortion Product Otoacoustic Emissions [0.03%]
基于耳声发射的生长和非线性结构方程特征研究
Shawn S Goodman,M Ehsan Khalili,Julia H Roemen et al.
Shawn S Goodman et al.
Purpose: Distortion product otoacoustic emission (DPOAE) magnitudes measured in the ear canal in response to a range of primary stimulus levels as growth functions (GFs) may be useful for assessing cochlear non-linearity,...
Age-dependent Shifts in Spiral Ganglion Neuron Subtypes Are Associated with Interphase Gap-dependent Modulation of Electrically Evoked Compound Action Potentials in Mice [0.03%]
小鼠耳蜗神经元亚型年龄相关变化与听觉脑干反应波幅的年龄依赖性减小有关
Nafisa Tursun,Linhan Huang,Min Chen et al.
Nafisa Tursun et al.
Purpose: Older adults with profound hearing loss can derive substantial benefit from cochlear implants (CIs), yet outcomes are more variable than in younger recipients. Degeneration of spiral ganglion neurons (SGNs) is a ...