Identification of potential inhibitors of interleukin-2-inducible T-cell kinase: insights from docking, molecular dynamics, MMPBSA and free energy landscape studies [0.03%]
基于对接、分子动力学、MMPBSA及自由能景观研究的T细胞激酶潜在抑制剂的识别
Shazia Ahmed,Arunabh Choudhury,Mohammad Umar Saeed et al.
Shazia Ahmed et al.
Interleukin-2-inducible T-cell kinase (ITK) is an essential enzyme that plays a key role in both the activation and differentiation of T-cells. As a member of the Tec family of non-receptor tyrosine kinases, ITK is predominantly expressed i...
Synthesis of novel bisazlactones and their applications in the synthesis of a new family of pseudo-peptide enamides with anti-cancer properties [0.03%]
具有抗癌活性的新型伪肽烯胺类化合物家族的合成及其前体bis-azlactone的合成研究
Azim Ziyaei Halimehjani,Farzaneh Noorakhtar
Azim Ziyaei Halimehjani
Pseudo-peptides are an important category of biologically active artificial small molecules. To access these important molecules, a novel series of bisazlactones was synthesized via the Erlenmeyer-Plöchl reaction, using glycine- and tereph...
Evaluation of safe utilization of L-threonine for supplementation in healthy adults: a randomized double blind controlled trial [0.03%]
L-丝氨酸在健康成人中的安全性和利用度补充评价：随机双盲对照试验
Hideki Matsumoto,Naoki Miura,Masaki Naito et al.
Hideki Matsumoto et al.
L-threonine is used in dietary supplements and nutritional products ingested by healthy consumers. The objective of this study was to determine in a randomized double blind controlled clinical trial the safety and tolerability of L-threonin...
Randomized Controlled Trial
Amino acids. 2025 May 27;57(1):30. DOI:10.1007/s00726-025-03461-6 2025
Dietary exposure to creatine-precursor amino acids in the general population [0.03%]
一般人群接触肌酸前体氨基酸的膳食暴露量
David Nedeljkovic,Sergej M Ostojic
David Nedeljkovic
Background: Creatine is a semi-essential nutrient that plays a critical role in energy metabolism, with dietary intake and endogenous synthesis contributing to overall creatine availability. While dietary creatine intake ...
Cationic antimicrobial peptide CC34 potential anticancer and apoptotic induction on cancer cells [0.03%]
阳离子抗菌肽CC34的潜在抗肿瘤及诱导癌细胞凋亡作用
Liqiang Dong,Yunhe Li,Yaguang Zhang et al.
Liqiang Dong et al.
To evaluate the potential of antimicrobial peptide CC34 for use as therapeutic agents for gastric cancer SGC-7901 and hepatocellular carcinoma HepG-2. In this study, the antibacterial activity and antibacterial mechanism were tested by the ...
Targeting LAT1 with JPH203 to reduce TNBC proliferation and reshape suppressive immune microenvironment by blocking essential amino acid uptake [0.03%]
JPH203靶向LAT1通过阻断必需氨基酸摄取来抑制三阴性乳腺癌增殖和重塑免疫抑制微环境
Yajie Zhao,Chunrui Pu,Kangdong Liu et al.
Yajie Zhao et al.
The competitive uptake of essential amino acids (EAAs) by breast cancer cells is associated with poor patient prognosis and the development of an immunosuppressive tumor microenvironment. L-type amino acid transporters, LAT1 (SLC7 A5) and L...
Effect of histidine and carnosine on haemoglobin recovery in anaemia induced-kidney damage and iron-loading mouse models [0.03%]
组氨酸和卡尼丁对贫血诱导的肾损伤及铁过载小鼠模型中血红蛋白恢复的影响
Mayra Vera-Aviles,Jorge Moreno-Fernandez,Tugba Kose et al.
Mayra Vera-Aviles et al.
Histidine and carnosine can form complexes with divalent metal ions such as Fe2+, potentially providing stability to intracellular labile iron. Anaemia is a common comorbidity in the late stages of kidney disease, and patients are treated w...
Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review [0.03%]
L-鸟氨酸口服摄入在健康受试者中的安全性评估：一项系统性回顾
Hyemin Yang,Yui Kuramochi,Sumika Sato et al.
Hyemin Yang et al.
L-Ornithine (L-Orn) is a nonessential amino acid but has many physiological roles. Accordingly, L-Orn has been used as a functional food or dietary supplement to ameliorate various maladies, but there is only limited information available a...
Metabolomic analysis reveals key changes in amino acid metabolism in colorectal cancer patients [0.03%]
代谢组学分析揭示结直肠癌患者氨基酸代谢的关键变化
Asmaa Ramzy,Taghreed Khaled Abdelmoneim,Menna Arafat et al.
Asmaa Ramzy et al.
The number of colorectal cancer (CRC) patients is steadily growing worldwide, particularly in developing nations. Nonetheless, recent advances in early detection studies and therapy alternatives have reduced CRC mortality in affluent countr...
Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma [0.03%]
牛磺酸代谢相关基因预后标志物的整合分析与免疫疗法及鼻咽癌关键基因ABCB1和GORASP1的鉴定
Zhang Feng,Yuhang Yang,Wenqi Luo et al.
Zhang Feng et al.
Taurine is an amino acid with several physiological functions and has been shown to be involved in the anti-tumor of human nasopharyngeal carcinoma (NPC) cells. However, the role of taurine metabolism-related genes (TMRGs) in NPC has not be...