IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma [0.03%]
IGF2BP1介导的ABCA1甲基化通过影响胆固醇代谢促进肺腺癌进展
Shaohua Xu,Kai Liu,Zhao Chen et al.
Shaohua Xu et al.
ABCA1 is a key protein in maintaining cholesterol homeostasis, and its abnormal expression is associated with the progression of many cancers. Nonetheless, the specific molecular mechanisms by which ABCA1 facilitates the development of LUAD...
Insight into the structure of antitubercular Callyaerins: conformational studies and synthesis of a unique dehydroamino acid, β-aminodehydroalanine [0.03%]
抗结核药物Callyaerins的结构研究：构象分析及独特脱氢氨基酸β-氨基脱氢丙氨酸的合成
Karolina Banaś,Paweł Lenartowicz,Dawid Siodłak
Karolina Banaś
β-Aminodehydroalanine, ΔAla(β-NH), (2,3-diaminoprop-2-enoic acid), is a unique dehydroamino acid and a central component of Callyaerins A-M and Callynormine A. The presence of this unusual structural element containing an enamine functio...
Post-translational modifications of ezrin: a crucial regulator for diseases [0.03%]
易位蛋白的翻译后修饰：疾病的关键调节因子
Yi-Chen Li,Hong-Kai Yuan,Lei-Miao Yin
Yi-Chen Li
Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biologica...
The effect of L-Arg supplementation on L-Arg/NO metabolic and AMPK/ACC-1 signalling pathways in adipose cells (3T3 L1) [0.03%]
L-精氨酸补充对脂肪细胞(L-精氨酸/一氧化氮代谢和AMPK/ACC-1信号途径)的影响
Saranya Prashath
Saranya Prashath
L-arginine (L-Arg) is metabolised in the cell to generate nitric oxide (NO) and citrulline via nitric oxide synthase (NOS). NO is an important cellular signalling molecule that regulates lipid and glucose metabolism. The biological availabi...
Protective effects of S-adenosyl methionine on oxidative stress and tissue damage in STZ-induced diabetic rats [0.03%]
SAM对链脲佐菌素诱导的糖尿病大鼠氧化应激及组织损伤的保护作用
AmirHossein RahimBakhsh,Asma Kheirollahi,Akram Vatannejad et al.
AmirHossein RahimBakhsh et al.
Background: Oxidative stress is a key contributor to the progression of diabetes mellitus and its associated complications. Recently, S-adenosyl methionine (SAM) has shown promise in mitigating oxidative stress and improv...
CacyBP/SIP - RPL6 interaction: potential influence on ribosome function [0.03%]
CacyBP/SIP-RPL6相互作用对核糖体功能的影响研究
Ewelina Jurewicz,Małgorzata Maksymowicz-Trivedi,Omid Saberi-Khomami et al.
Ewelina Jurewicz et al.
Previously, we have shown that CacyBP/SIP interacts with NPM1, a protein involved in ribosome biogenesis. In this work, we extended our previous studies to look for the potential impact of CacyBP/SIP on ribosome biogenesis and/or function. ...
Construction of a co-reaction system for ethanol-promoted gamma-aminobutyric acid synthesis by Pediococcus pentosaceus [0.03%]
丙氨酸棒状杆菌促乙醇合成γ-氨基丁酸协同反应体系的构建
Sheng-Yuan Yang,Yuan-Jun Li,Wan-Chun Hong
Sheng-Yuan Yang
The biotransformation of L-glutamic acid (L-Glu) to γ-aminobutyric acid (GABA) using glutamate decarboxylase (GAD) in microbial whole cells represents an ideal approach for biosynthesis of food-grade and pharmaceutical-grade GABA. To overc...
Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D [0.03%]
蛋白质和多肽的乙型肝炎病毒前C区变异型式及与δ抗原的关系获奖地区奖文摘
Sandra Rodrigues Xavier,Isabelle Caroline Dos Santos Barcelos,Isadora Braga Gandra et al.
Sandra Rodrigues Xavier et al.
Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to publ...
Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins [0.03%]
尿毒症毒素对称性二甲基精氨酸(SDMA)的肾转运蛋白转运作用
Lorenz A Scherpinski,Martin F Fromm,Renke Maas et al.
Lorenz A Scherpinski et al.
The L-arginine derivative and uremic toxin symmetric dimethylarginine (SDMA) is an independent risk marker for total mortality and cardiovascular events. Interferences with L-arginine- or L-homoarginine-related signaling, metabolism, or tra...
Enhanced γ-aminobutyric acid levels promote degeneration of silk glands following spermidine supplementation in Bombyx mori [0.03%]
丝胺酸补充通过提高γ-氨基丁酸水平促进家蚕吐丝腺退化
Brinda Goda Lakshmi Didugu,Anitha Mamillapalli
Brinda Goda Lakshmi Didugu
Silk glands are modified labial glands that produce silk which has immense commercial importance. Silk is extruded out in liquid form after which the glands undergo autophagy and apoptosis during larval to pupal transition. Biogenic amines,...