NGS and the design of an optimized phage display workflow for peptide discovery [0.03%]
基于NGS的优化噬菌体展示工作流程的设计用于肽段发现
Babak Bakhshinejad,Andreas Kjaer
Babak Bakhshinejad
Phage display is a powerful technology that has demonstrated great potential in identifying peptides with high binding affinity and specificity toward a broad spectrum of biological targets. The undesired enrichment of nonspecific binders r...
MTR4 methylation-dependent degradation activates mTORC1 signaling to promote glioma cell survival under methionine starvation [0.03%]
甲硫氨酸饥饿时MTR4甲基化依赖性降解激活mTORC1信号促进胶质瘤细胞存活
Lude Wang,Qiuwen Lou,Jie Chang et al.
Lude Wang et al.
Evaluation of the clinical characteristics and potentially prognostic factors in HER2-positive breast cancer [0.03%]
评估HER2阳性乳腺癌的临床特征及潜在预后因素
Liang Shi,Pei-Wen Xi,Zhi Li et al.
Liang Shi et al.
From January 2000 to December 2019, the SEER Plus Database collecting human epidermal growth factor receptor 2 (HER2) and hormone receptor (HR; including estrogen receptor [ER] and progesterone receptor [PR]) status for breast cancer (BC) c...
Evaluation of the antimicrobial-cytotoxic activities and molecular docking study of L-cysteine ethyl ester and L-cysteine methyl ester [0.03%]
L-半胱氨酸乙酯和L-半胱氨酸甲酯的抑菌细胞毒性评价及分子对接研究
Tuğçe Deniz Karaca,Hüseyin Balcı,Arzu Aysan et al.
Tuğçe Deniz Karaca et al.
Antibiotic resistance is a growing problem in the treatment of life-threatening diseases. Recently, a variety of covalent drugs have emerged. Cysteine is one of the least abundant amino acids in the proteins of many organisms, and the t...
Impacts of conditionally essential amino acids, cysteine, and tyrosine on intestinal inflammation in celiac disease [0.03%]
半胱氨酸和酪氨对乳糜泻肠炎的影响
Mohadeseh Mahmoudi Ghehsareh,Sajjad Bakhtiari,Nastaran Asri et al.
Mohadeseh Mahmoudi Ghehsareh et al.
Celiac disease (CD) is a chronic autoimmune disorder characterized by gluten-induced intestinal inflammation, epithelial barrier dysfunction, and malabsorption of nutrients, including amino acids (AAs). While essential AAs have been extensi...
Aromatic amino acid-metal ion interactions: comparative effects of alkali and Zn2+ on acidity and coordination behavior via QM studies [0.03%]
芳香族氨基酸-金属离子相互作用：通过QM研究比较碱和Zn2 +对酸度和配位行为的影响
Sepideh Kalhor,Alireza Fattahi
Sepideh Kalhor
Among the 20 standard amino acids, aromatic amino acids hold particular importance due to their crucial roles in protein-protein interactions. These residues, including phenylalanine, tyrosine, tryptophan, and histidine, contribute signific...
Novel octapeptide containing the RGD sequence as a potential anti-SARS-CoV-2 agent: design, synthesis, and theoretical studies [0.03%]
一种新的含RGD序列的八肽抗SARS-CoV-2剂：设计、合成和理论研究
Reiner Lemos,Orlando Ortiz,Luis Almagro et al.
Reiner Lemos et al.
The design of peptide-based inhibitors targeting cell receptors represents a promising strategy in the development of antiviral agents. In this study, a novel octapeptide containing the RGD sequence was rationally designed to explore its po...
Decoding incretin resistance: a mechanistic framework to reclassify therapeutic variability for GLP-1 receptor agonist therapy [0.03%]
从头解析肠促胰素抵抗：GLP-1受体激动剂治疗变异性再分类的机制框架
Almir Fajkić,Yun Wah Lam,Andrej Belančić
Almir Fajkić
This article introduces a mechanistic framework to reclassify suboptimal responses to GLP-1 receptor agonists. It defines three mechanistic subtypes of incretin resistance-receptor-level, post-receptor, and secretory-highlighting their dist...
Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study [0.03%]
必需氨基酸补充治疗压疮的病理生理学依据及一项初步研究结果
Maciej Świątkiewicz,Andrzej Lejczak,Piotr Foltyński et al.
Maciej Świątkiewicz et al.
Pressure ulcers (PU) are a major and serious problem affecting millions of people. Malnutrition, frequently co-occurring with PU, is considered modifiable risk factor, and dietary supplements currently recommended for supporting PU healing ...
Intelligent design and synthesis of nucleobase and amino acid-based ligands to inhibit the JAK2 enzyme to treat rheumatoid arthritis [0.03%]
智能设计和合成核碱基及氨基酸衍生物小分子配体抑制jak2酶治疗类风湿性关节炎研究
Ameneh Zarei,Alireza Fatahi
Ameneh Zarei
Rheumatoid arthritis is the most prevalent form of autoimmune arthritis. In modern drug development, computer-aided drug design plays a crucial role not only in discovering new therapeutic compounds but also in assessing their potential eff...