Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study [0.03%]
必需氨基酸补充治疗压疮的病理生理学依据及一项初步研究结果
Maciej Świątkiewicz,Andrzej Lejczak,Piotr Foltyński et al.
Maciej Świątkiewicz et al.
Pressure ulcers (PU) are a major and serious problem affecting millions of people. Malnutrition, frequently co-occurring with PU, is considered modifiable risk factor, and dietary supplements currently recommended for supporting PU healing ...
Intelligent design and synthesis of nucleobase and amino acid-based ligands to inhibit the JAK2 enzyme to treat rheumatoid arthritis [0.03%]
智能设计和合成核碱基及氨基酸衍生物小分子配体抑制jak2酶治疗类风湿性关节炎研究
Ameneh Zarei,Alireza Fatahi
Ameneh Zarei
Rheumatoid arthritis is the most prevalent form of autoimmune arthritis. In modern drug development, computer-aided drug design plays a crucial role not only in discovering new therapeutic compounds but also in assessing their potential eff...
Dmytro Demash,Olena Stasyk,Oleh Stasyk
Dmytro Demash
Plants are known as a source of different biologically active compounds, which are uncommon for other kingdoms of life. Among them are different amino acid analogues, which are synthesized and accumulated in certain plants as a passive defe...
Myocardial protection by acidic amino acids and natural dipeptides: potential for an underused resource [0.03%]
酸性氨基酸和天然二肽的心肌保护作用：一种被低估资源的潜力
N King
N King
Stopping then restarting the blood flow to the heart can cause ischaemia reperfusion (IR) injury. This can happen during revascularisation following a myocardial infarction and during on pump cardiac surgery using cardioplegic arrest. Despi...
Lysine malonylation as a therapeutic target: implications for metabolic, inflammatory, and oncological disorders [0.03%]
赖氨酸琥珀酰化作为治疗靶点的潜在作用：对代谢、炎症和肿瘤疾病的启示
Ahsanullah Unar
Ahsanullah Unar
Lysine malonylation (Kmal) is an emerging posttranslational modification (PTM) intricately linked to cellular metabolism and disease pathogenesis. This review explores the regulatory mechanisms of Kmal, emphasizing the role of malonyl-CoA a...
Evaluation of processing of canola protein isolate on postprandial plasma amino acid profiles in healthy, young females [0.03%]
评价菜籽蛋白分离物对健康年轻女性餐后血浆氨基酸谱的影响
Noortje Boot,Wesley J H Hermans,Ines Warnke et al.
Noortje Boot et al.
Canola protein is a rapeseed-derived protein that contains all essential amino acids in proportions that meet the WHO amino acid scoring requirements, making it an interesting protein for human food applications. It is currently unknown whe...
Randomized Controlled Trial
Amino acids. 2025 Oct 17;57(1):50. DOI:10.1007/s00726-025-03482-1 2025
Exploring claudin proteins: from sequence motifs to their impact on tight junction-mediated signaling pathways [0.03%]
Claudin蛋白的研究：从序列基元到其对紧密连接介导的信号通路的影响
Lingling Bao,Siqi Yang,Wenhua Zhao et al.
Lingling Bao et al.
Claudin (CLDN) proteins are extensively studied due to their critical role in maintaining tissue barriers and cell polarity. However, significant gaps remain in understanding the functional mechanisms of their sequence motifs and the molecu...
Protolytic properties and biological activity of spinorphin and its butyric acid derivatives in aqueous solution [0.03%]
spinorphin及其丁酸衍生物的水溶液中的质子解离性质及生物学活性
Marek Pająk,Elżbieta Kamysz,Marcin Banach et al.
Marek Pająk et al.
The present work describes the protolytic properties and in vitro biological activity of spinorphin (Leu-Val-Val-Tyr-Pro-Trp-Thr) and three spinorphin derivatives containing butyric acid residue: Butyryl-Lys-Lys-Leu-Leu-Val-Tyr-Pro-Trp-Thr,...
Associations between XRCC1-Arg399Gln polymorphism and the risk of prostate cancer: an updated meta-analysis [0.03%]
XRCC1-Arg399Gln多态性与前列腺癌风险的关联：一项更新的meta分析
Jiang Deng,Lihua Xu,Jun Zhou et al.
Jiang Deng et al.
The X-ray repair cross-complementary group 1 (XRCC1) gene 399 codon polymorphism may alter the structure of DNA repair enzymes to regulate DNA repair capacity. Impaired DNA repair ability can lead to the development of cancers such as prost...
Meta-Analysis
Amino acids. 2025 Sep 18;57(1):46. DOI:10.1007/s00726-025-03475-0 2025
Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties [0.03%]
基于牛乳酪蛋白的抗菌肽理性设计、合成及生物学性质评价
Seyed Reza Pourhosseini,Bahman Akbari,Elahe Ghods et al.
Seyed Reza Pourhosseini et al.
The overuse of antibiotics has led to a growing crisis-antimicrobial resistance, making it harder to treat infections and pushing scientists to find new solutions. Among the most promising alternatives are bioactive peptides, especially ant...