Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms [0.03%]
牛磺酸补充剂和系统性红斑狼疮的前临床研究：临床结局及潜在机制的系统综述
Aida Malek Mahdavi,Zeinab Javadivala,Niloufar Orooji
Aida Malek Mahdavi
Taurine (Tau) is a sulfur-containing amino acid that has therapeutic roles in several diseases, including inflammatory conditions. The involvement of Tau in modulating systemic lupus erythematosus (SLE) autoimmunity has been indicated in pr...
Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging [0.03%]
SIRT1、多胺及miRNA编辑在癌症和衰老中的失调
Miora Bruna Marielle Ramamonjiharisoa,Sen Liu
Miora Bruna Marielle Ramamonjiharisoa
Interest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emergi...
Arginine improves growth and health status of post-larval Litopenaeus vannamei by modulating amino acid metabolism and enhancing antioxidative defense [0.03%]
精氨酸通过调节仔虾半胱天冬酶代谢和抗氧化防御功能促进凡纳滨对虾溞状幼体期后的生长及健康状态的改善
Xianjie Chen,Hongjie Xie,Yifei Pan et al.
Xianjie Chen et al.
This study investigated the dietary arginine requirement for post-larval Litopenaeus vannamei based on growth performance and hepatopancreatic health indicators. A 25-day feeding trial was conducted. Five iso-nitrogenous and iso-lipidic die...
Association between plasma concentrations of galectin 3, growth differentiation factor 15, soluble suppression of tumourigenicity 2, and cystatin C and clinical parameters and survival in patients with end-stage renal disease undergoing haemodialysis [0.03%]
终末期肾病患者血浆半乳糖凝集素-3、生长分化因子-15、可溶性肿瘤抑制剂-2和胱抑素C浓度与临床参数及生存率的相关性研究
Michał Ptak,Aleksandra Cader-Ptak,Zuzanna Marcinowska et al.
Michał Ptak et al.
The treatment of chronic kidney disease is based mainly on haemodialysis. During this procedure, cardiovascular haemodynamic parameters change, which can lead to complications in the circulatory system and shorten patient survival. Currentl...
Plasma branched-chain amino acids in chronic kidney disease: associations with atherogenic lipids and mortality [0.03%]
慢性肾病患者血浆支链氨基酸与动脉粥样血脂和死亡率的关系
Mohamed E Suliman,Abdul Rashid Qureshi,Dario Troise et al.
Mohamed E Suliman et al.
Branched-chain amino acids (BCAAs) are essential nutrients that promote muscle protein anabolism but also associate with cardiometabolic diseases; however, their role in chronic kidney disease (CKD) remains unclear. We investigated plasma B...
Targeting amino acid metabolic pathways: a novel therapeutic strategy for hyperuricemia-associated complications [0.03%]
靶向氨基酸代谢通路：高尿酸血症相关并发症的一种新型治疗策略
Xinya Zhang,Wenkai Wang,Le Yang et al.
Xinya Zhang et al.
Hyperuricemia (HUA) is a metabolic disorder that contributes to the pathogenesis of gout arthritis (GA), chronic kidney disease (CKD), and cardiovascular disease (CVD). While current urate-lowering therapies effectively reduce serum uric ac...
Amino acid metabolism-related model for prognosis and immunity in gastric cancer [0.03%]
胃癌预后及免疫的氨基酸代谢相关模型
Huan Zhang,Wei Ye,Lingzhi Zeng et al.
Huan Zhang et al.
Amino acid metabolic (AAM) reprogramming is a key characteristic of gastric cancer (GC) cells metabolic remodeling, which regulates cell growth, survival, immune cell activation and function to affect tumor immune escape. This study aims to...
Branched-chain polyamines: evolutionary adaptation and biotechnological potential [0.03%]
支链多胺：进化适应与生物技术潜力
Shinsuke Fujiwara,Wakao Fukuda
Shinsuke Fujiwara
Branched-chain polyamines (BCPAs), exemplified by N⁴-bis(aminopropyl)spermidine, are distinctive polycations that occur predominantly in thermophilic bacteria and euryarchaeal archaea. Their dedicated aminopropyltransferase, BpsA (EC 2.5.1...
Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation [0.03%]
色氨酸代谢重编程调控Th1/Th2免疫平衡及抑制mast细胞活化
Dongsheng Huang,Dongxuan Huang,Lianhui Su et al.
Dongsheng Huang et al.
Asthma is characterized by chronic airway inflammation and an imbalanced Th1/Th2 response. Although tryptophan metabolism has been implicated in immune regulation, its direct influence on Th1/Th2 differentiation and mast-cell activation rem...
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders [0.03%]
益生菌和微生物对多胺产生的调节作用：在神经退行性疾病中保护神经细胞的新途径
Tushar Adhikari,Prerona Saha
Tushar Adhikari
Neurodegenerative disorders are an Critical worldwide issue, characterized by progressive neuronal loss and cognitive decline with limited effective therapies. A central problem in these conditions is chronic neuroinflammation, oxidative st...