PCLPred: identifying plant chloride transport-related proteins using reduced amino acid alphabets and N-peptide composition [0.03%]
基于降维氨基酸字母和N-肽组成的植物氯离子运输相关蛋白识别方法PCLPred
Ge Bai,Lijia Liu,Hui Zhang et al.
Ge Bai et al.
Chloride transport-related proteins play critical roles in coordinating ion cycling, maintaining cellular homeostasis, and enabling plants to dynamically adapt to environmental changes, particularly under salt stress conditions. Given the r...
Targeting the amino acid metabolic axis: the Achilles' heel of tumor cells [0.03%]
靶向氨基酸代谢轴：肿瘤细胞的阿喀琉斯之踵
Zheyu Hu,Yiwei Wang,Qian Ma
Zheyu Hu
Cancer is characterized by profound reprogramming of its metabolic programs, with the unending demand for exogenous amino acids by tumor cells serving as a hallmark manifestation. While this high dependency supports rapid proliferation, it ...
Revisiting the antizyme 1 - ODC interaction reveals low-nanomolar affinity [0.03%]
重新研究的抗酶素1-鸟氨酸脱羧酶相互作用显示低纳摩尔亲和力
Grzegorz P Bereta,Elżbieta Wątor-Wilk,Paweł Kochanowski et al.
Grzegorz P Bereta et al.
Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is one of the shortest-lived mammalian proteins. Its activity and proteasomal degradation are controlled by antizyme (AZ), which disrupts the activ...
Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs [0.03%]
精氨酸补充增加母体饮食中瓜氨酸的含量可促进胎儿生长并编程羔羊的胰腺发育
Alissa B Herring,Kyle S Herron,London G Lemcke et al.
Alissa B Herring et al.
Intrauterine growth restriction (IUGR), caused by maternal undernutrition, impairs fetal growth and increases the risk for postnatal metabolic dysfunction. L-arginine can mitigate these effects; however, its use in sheep is limited by rumin...
Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications [0.03%]
肿瘤中的氮代谢重编程：机制和治疗意义
Jiaqi Fang,Jing Ling,Xinyue Liu et al.
Jiaqi Fang et al.
Nitrogen metabolism plays a key role in maintaining normal physiological functions of the organism and cell proliferation and differentiation. Nitrogen metabolism in normal human body maintains a dynamic balance to meet the body's demand fo...
Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities [0.03%]
粗纹管角颈扭棱蜘蛛C末端环区氨基酸稍有不同的蜘蛛毒素多肽其杀虫活性不同
Herlinda Clement,Lilu Corrales-García,Víctor Carpanta et al.
Herlinda Clement et al.
The insecticidal molecules of spiders persistently evolve to ensure rapid paralysis of their prey, and the best molecules are transmitted to their progeny. Here, we cloned two insecticidal peptides, Bs2 and Bs3, from the venom glands of the...
The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed [0.03%]
K6/ODC小鼠的非凡遗产：揭示多胺促肿瘤发生的机制
Susan K Gilmour
Susan K Gilmour
Using the well-studied two-stage model of skin carcinogenesis, the first transgenic mouse with targeted expression of a polyamine metabolic enzyme was generated 30 years ago. Ornithine decarboxylase (ODC), a key regulating enzyme of polyami...
At the core of global bioenergy: polyamines and transglutaminases in chloroplasts [0.03%]
叶绿体聚胺和转谷氨酰胺酶位于全球生物能源的核心位置
Donatella Serafini-Fracassini,Stefano Del Duca
Donatella Serafini-Fracassini
Chloroplasts are the energy factories of photosynthetic life. The energy and the plant biomass of the planet depend on the activity of chloroplasts. Their efficiency results from a delicate balance between membrane organization, metabolic r...
The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes [0.03%]
N-乙酰半胱氨酸和谷胱甘肽在帕金森病管理中的作用：氧化生物标志物和临床结果的系统评价
Imran Mohammed,Yasimin Nankya,U Teng Hong et al.
Imran Mohammed et al.
Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons, leading to both motor and non-motor symptoms. Oxidative stress is a significant contributor to the pathophysiology of PD...
Adaptive crosstalk between polyamine metabolism, translation, and autophagy sustains energy homeostasis in mammals during starvation: a scoping review [0.03%]
多胺代谢、翻译和自噬在哺乳动物饥饿期间维持能量稳态的适应性串扰：系统综述
Kayhan Karimi,Sigrid C Roberts,Nicola S Carter et al.
Kayhan Karimi et al.
Mammalian cells tightly regulate the shift between catabolism and anabolism to maintain energy homeostasis during starvation. Among other adaptations, cells adapt to nutrient restriction by downregulating translation, the most energy consum...