LC-MS assay for quantifying ornithine decarboxylase activity in the biological matrix and cultured cells using stable isotope‑labeled ornithine [0.03%]
使用稳定同位素标记鸟氨酸测定生物基质和培养细胞中的鸟氨酸脱羧酶活性的LC-MS法
Yuma Shiomi,Naoya Ogawa,Kentaro Takahama et al.
Yuma Shiomi et al.
Polyamines (putrescine, spermidine, and spermine) are essential for animal health and development, and their intracellular levels must be tightly regulated to maintain normal cellular functions. Ornithine decarboxylase (ODC) catalyzes the r...
Deciphering the molecular heterogeneity of HER2-positive breast cancer: the critical interplay of hormone receptor status and transcriptomic landscapes [0.03%]
揭秘HER2阳性乳腺癌分子异质性：激素受体状态与转录组景观的关键互作
Ilker Sengul,Demet Sengul,Cagri Akalin
Ilker Sengul
The clinical management of HER2-positive breast cancer is undergoing a paradigm shift, recognizing that hormone receptor (HR) co-expression defines a fundamental biological dichotomy rather than a minor clinical variation. This perspective ...
Computational identification of antigens and development of a multi-epitope vaccine for bacterial vaginosis caused by Gardnerella vaginalis [0.03%]
计算鉴定细菌性阴道炎生物疫苗抗原表位及多表位疫苗设计开发
Mohammad Amin Niknezhad,Abbas Doosti,Mostafa Shakhsi-Niaei
Mohammad Amin Niknezhad
Bacterial vaginosis (BV), a prevalent form of vaginal dysbiosis, is primarily caused by Gardnerella vaginalis. The increasing prevalence of BV has raised global health concerns, prompting the need for a vaccine that can enhance human immuni...
L-Proline protects human sperm from heat stress-induced oxidative damage [0.03%]
L-脯氨酸保护人类精子免受热应激引起的氧化损伤
Mojtaba Moradi,Mohsen Shayestehyekta,Amir Hossein Hashemian et al.
Mojtaba Moradi et al.
L-proline, an amino acid with antioxidant properties, has demonstrated significant potential in counteracting oxidative stress and preserving sperm quality. This study evaluated the protective effects of L-proline against heat stress-induce...
Assessment of molecular interactions and anti-inflammatory activity of fermented camel milk-derived peptides in RAW macrophages [0.03%]
发酵骆驼奶衍生肽与RAW巨噬细胞间分子相互作用及抗炎活性的评估
Prashantkumar Natubhai Padhiyar,Bethsheba Basaiawmoit,Pooja M Mankad et al.
Prashantkumar Natubhai Padhiyar et al.
Fermented camel milk is gaining attention as a functional food due to the formation of bioactive peptides during microbial fermentation. This study aimed to investigate the generation of bioactive peptides and their associated antidiabetic,...
Taurine reduces intracellular glucose accumulation in fructose-treated Caenorhabditis elegans [0.03%]
牛磺酸减少果糖处理的秀丽隐杆线虫细胞内葡萄糖积累
Joelma Capungo Machado,Bruno Ayala Vidal,Bruna Haendchen Sant&#x;Ana et al.
Joelma Capungo Machado et al.
Regulation of glucose homeostasis is a central feature of antidiabetic drugs such as metformin. However, a subset of individuals exhibited limited therapeutic response, highlighting the need for complementary treatment strategies. Taurine, ...
Computational identification and characterization of noncoding RNA-encoded peptides: tools, databases, and in silico strategies [0.03%]
非编码RNA编码肽的计算识别与特征分析：工具、数据库及计算机策略
Nidhi Shenoy,Atharva Karkare,Varsha Gangadhar et al.
Nidhi Shenoy et al.
Once dismissed as transcriptional artifacts, noncoding RNAs (ncRNAs) have gained recognition in recent years for their ability to participate in gene regulation, as well as their ability to encode functional molecules referred to as ncRNA-e...
Methionine concentration regulates LSD1 acetylation in glioma cells [0.03%]
蛋氨酸浓度通过调节组蛋白脱乙酰基酶LSD1的乙酰化来抑制胶质瘤生长
Jie Chang,Lude Wang,Yi Pan et al.
Jie Chang et al.
Glioma is a highly aggressive brain cancer with poor prognosis, characterized by vigorous methionine metabolism. While methionine restriction demonstrates broad anticancer effects, its mechanistic relationship with epigenetic regulators in ...
Efficient acrylamide adduct formation suggests dual applications of ReAIV L-asparaginase [0.03%]
高效的丙烯酰胺加合物形成表明ReAIV天冬酰胺酶的双重应用
Joanna Sliwiak,Marta Grzechowiak,Paulina Worsztynowicz et al.
Joanna Sliwiak et al.
Isothermal titration calorimetry (ITC) studies of the enzyme kinetics and substrate specificity of Rhizobium etli Class 3 L-asparaginases, ReAIV (constitutive) and ReAV (inducible), showed that despite highly conserved catalytic site, the t...
Analysis of total and free amino acid compositions of fishery byproducts from three commonly consumed fish species in South Korea [0.03%]
三种韩国常见食用鱼类加工副产物的总氨基酸和游离氨基酸组成分析
Jeonghoon Han,Ji-Yeon Hyeon,Yeon-Ju Lee et al.
Jeonghoon Han et al.
Largehead hairtail (Trichiurus japonicus), kwangtung skate (Dipturus kwangtungensis), and mottled skate (Raja pulchra) are the most popular aquatic products in Korea. In the present study, total and free amino acid analyses were performed t...