Pre-clinical study of a TNFR1-targeted 18F probe for PET imaging of breast cancer [0.03%]
靶向TNFR1的氟-18放射性探针用于乳腺癌正电子发射断层扫描成像的临床前研究
Hao Fu,Hua Wu,Xianzhong Zhang et al.
Hao Fu et al.
Tumor necrosis factor receptor 1 (TNFR1) is overexpressed in several varieties of carcinoma, including breast cancer. WH701 (Ala-Thr-Ala-Gln-Ser-Ala-Tyr-Gly), which was identified by phage display, can specifically bind to TNFR1. In this st...
Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630 [0.03%]
肽KW4在LTA诱导和耐药金黄色葡萄球菌1630诱导的RAW 264.7细胞炎性反应中的抗内毒素作用机制研究
Jong-Kook Lee,Yoonkyung Park
Jong-Kook Lee
Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular, Staphylococcus aureus induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant ...
Investigation of the interaction of β-methylamino-L-alanine with eukaryotic and prokaryotic proteins [0.03%]
β-甲基胺-l- alanine与真核和原核蛋白相互作用的研究
Brendan J Main,Carly J Italiano,Kenneth J Rodgers
Brendan J Main
There is a strong body of evidence linking the non-protein amino acid (NPAA) β-methylamino-L-alanine (BMAA) to the development of a number of neurodegenerative diseases. BMAA has been found globally, is produced by a number of organisms in...
Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction? [0.03%]
孕产妇血浆不对称二甲基精氨酸（ADMA）与胎盘灌注受损孕妇的新生儿体重百分位数呈反比关系：循环中的ADMA是独立于NO的胎儿生长受限指标？
Dimitrios Tsikas,Alexander Bollenbach,Makrina D Savvidou
Dimitrios Tsikas
L-Arginine (Arg) is the enzymatic precursor of nitric oxide (NO) which has multiple biological functions. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of NO. We hypothesized that the ADM...
Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile [0.03%]
一种响尾蛇多肽口服给药高效抑制肿瘤生长且对宿主无毒副作用并能改善动物代谢状态
Joana D Campeiro,Marcelo P Marinovic,Fernando Cintra Carapeto et al.
Joana D Campeiro et al.
The efficacy of crotamine as antitumoral was first demonstrated by daily intraperitoneal (IP) injections of low doses of this toxin in an animal model bearing melanoma tumors. Significant inhibition of tumor growth and increased lifespan of...
Phosphorylation of pyridoxal 5'-phosphate enzymes: an intriguing and neglected topic [0.03%]
吡哆醛 5'- 磷酸酶的磷酸化：一个令人困惑且被忽视的话题
Giada Rossignoli,Robert S Phillips,Alessandra Astegno et al.
Giada Rossignoli et al.
Pyridoxal 5'-phosphate (PLP)-dependent enzymes catalyze a wide range of reactions of amino acids and amines, with the exception of glycogen phosphorylase which exhibits peculiar both substrate preference and chemical mechanism. They represe...
Imaging the expression of glypican-3 in hepatocellular carcinoma by PET [0.03%]
正电子发射断层扫描法成像检测肝细胞癌中 Glypican-3的表达
Zhen Wang,Yan-Jiang Han,Shun Huang et al.
Zhen Wang et al.
The glypican-3 (GPC3) receptor is overexpressed in hepatocellular carcinoma (HCC) and is a potential diagnostic and therapeutic target. GPC3-targeted molecular imaging will be helpful to differentiate diagnosis and guide therapy. In the pre...
Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications [0.03%]
针对VEGF受体的非中和环状多肽及其成像应用
Luisa Calvanese,Andrea Caporale,Giuseppina Focà et al.
Luisa Calvanese et al.
Pharmacological strategies aimed at preventing cancer growth are in most cases paralleled by diagnostic investigations for monitoring and prognosticating therapeutic efficacy. A relevant approach in cancer is the suppression of pathological...
Fibroblast-like synoviocyte migration is enhanced by IL-17-mediated overexpression of L-type amino acid transporter 1 (LAT1) via the mTOR/4E-BP1 pathway [0.03%]
IL-17介导的mTOR/4E-BP1信号转导调控滑膜fibroblast-like synoviocyte迁移中的L型氨基酸转运体1过度表达的作用及机制研究
Zhao Yu,Wang Lin,Zhang Rui et al.
Zhao Yu et al.
In rheumatoid arthritis (RA), activated synovial fibroblasts have the ability to invade joint cartilage, actively contributing to joint destruction in RA. The mechanisms underlying this cell migration and invasion remain unclear. Our previo...
Functional roles of agmatinase during the peri-implantation period of pregnancy in sheep [0.03%]
绵羊围产期agmatinase的功能角色
Yasser Y Lenis,Mohammed A Elmetwally,Wanjin Tang et al.
Yasser Y Lenis et al.
This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines i...