Understanding the antimicrobial properties/activity of an 11-residue Lys homopeptide by alanine and proline scan [0.03%]
系统评价十一肽Lys同聚肽抗菌性能/活性的丙氨酸和脯氨酸扫描法
P Carvajal-Rondanelli,M Aróstica,C A Álvarez et al.
P Carvajal-Rondanelli et al.
Previous work demonstrated that lysine homopeptides adopt a polyproline II (PPII) structure. Lysine homopeptides with odd number of residues, especially with 11 residues (K11), were capable of inhibiting the growth of a broader spectrum of ...
L-Arginine regulates protein turnover in porcine mammary epithelial cells to enhance milk protein synthesis [0.03%]
L-精氨酸通过调节猪乳腺上皮细胞蛋白周转增强乳蛋白合成
Qingquan Ma,Shengdi Hu,Makoto Bannai et al.
Qingquan Ma et al.
Milk is an important food for mammalian neonates, but its insufficient production is a nutritional problem for humans and other animals. Recent studies indicate that dietary supplementation with L-arginine (Arg) increases milk production in...
Selection and identification of novel peptides specifically targeting human cervical cancer [0.03%]
靶向人类宫颈癌新型肽段的选择与鉴定
Xiaomin Liu,Jingwen Peng,Jie He et al.
Xiaomin Liu et al.
Cervical cancer is the second most commonly diagnosed cancer and the third leading cause of cancer deaths among females in underdeveloped countries. This study aimed to identify several novel cervical cancer-specific targeting peptides (CSP...
Hepatic glutamate transport and glutamine synthesis capacities are decreased in finished vs. growing beef steers, concomitant with increased GTRAP3-18 content [0.03%]
育肥牛肝脏谷氨酸转运和谷氨酰胺合成能力下降与GTRAP3-18含量增加有关
J Huang,Y Jia,Q Li et al.
J Huang et al.
Hepatic glutamate uptake and conversion to glutamine is critical for whole-body N metabolism, but how this process is regulated during growth is poorly described. The hepatic glutamate uptake activities, protein content of system [Formula: ...
Comparative effects of acute-methionine loading on the plasma sulfur-amino acids in NAC-supplemented HIV+ patients and healthy controls [0.03%]
丙型肝炎合并艾滋病患者及健康人的血浆硫氨基酸急性蛋氨酸加载的比较效应
Roberto Carlos Burini,Maria Doroteia Borges-Santos,Fernando Moreto et al.
Roberto Carlos Burini et al.
In this study, an acute overloading of methionine (MetLo) was used to investigate the trassulfuration pathway response comparing healthy controls and HIV+ patients under their usual diet and dietary N-acetyl-L-cysteine (NAC) supplementation...
Clinical Trial
Amino acids. 2018 May;50(5):569-576. DOI:10.1007/s00726-018-2538-2 2018
Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis [0.03%]
甘氨酸促进3T3-L1脂肪细胞的脂联素和IL-10表达而不影响 adipogenesis 和lipolysis
Jingqing Chen,Xiaoshi Ma,Ying Yang et al.
Jingqing Chen et al.
Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain l...
A long non-coding RNA inside the type 2 transglutaminase gene tightly correlates with the expression of its transcriptional variants [0.03%]
II型组织转谷氨酰胺酶基因内的长链非编码RNA与其转录变体的表达密切相关
Linda Minotti,Federica Baldassari,Marco Galasso et al.
Linda Minotti et al.
The long non-coding RNAs (lncRNAs) are matter of intense investigation as potential regulators of gene expression. In the case of the transglutaminase 2 gene (TGM2) the databases of genome sequence indicate location of a lncRNA (LOC10798728...
Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides [0.03%]
抗微生物肽的抗葡萄球菌活性和细胞毒性受反离子的影响
Karol Sikora,Maciej Jaśkiewicz,Damian Neubauer et al.
Karol Sikora et al.
In view of an appreciable increase in resistance of Staphylococcus aureus to the conventional antibiotics, it is desired to develop new effective drugs. Antimicrobial peptides (AMPs) seem to be attractive candidates. In general, AMPs sample...
Genetically encoded photochemical covalent crosslinking within the Hcp-1 self-assembling bacterial secretion machinery [0.03%]
光化学交联在Hcp-1自我组装细菌分泌机器中的基因编码研究
Alicja K Antonczak,Kedric Milholland,Eric M Tippmann
Alicja K Antonczak
The target protein, Hcp1, was first described as part of the bacterial Type VI secretion system from Pseudomonas aeruginosa. The protein first self-assembles into a hexamer and then the hexamers further stack into a nanotubular structure. H...
Evaluation of peptides release using a natural rubber latex biomembrane as a carrier [0.03%]
利用天然胶乳生物膜作为载体评估肽类药物的释放性能
M C R Miranda,F A Borges,N R Barros et al.
M C R Miranda et al.
The biomembrane natural (NRL-Natural Rubber Latex), manipulated from the latex obtained from the rubber tree Hevea brasiliensis, has shown great potential for application in biomedicine and biomaterials. Reflecting the biocompatibility and ...