The application and prospects of antimicrobial peptides in antiviral therapy [0.03%]
抗菌肽在抗病毒治疗中的应用和前景
Fei Yang,Yunqi Ma
Fei Yang
Antimicrobial peptides (AMPs) have broad-spectrum antimicrobial activity, enabling them to rapidly detect and eliminate targets. In addition, many AMPs are natural peptides, making them promising candidates for therapeutic drugs. This revie...
Synthesis of enantiomerically enriched β-substituted analogs of (S)-α-alanine containing 1-phenyl-1H-1,2,3-triazole groups [0.03%]
含有1-苯基-1H-1,2,3-三唑基团的(S)-α-氨基乙酸β-位亚代产物的合成
Artavazd S Poghosyan,Emma A Khachatryan,Anna F Mkrtchyan et al.
Artavazd S Poghosyan et al.
A synthesis of new enantiomerically enriched derivatives of (S)-α-aminopropionic acid, containing in the β-position 1,2,3-triazole groups coupled with a o-, m- and p-substituted phenyl residue, was developed based on Cu(I) catalyzed [3 + ...
Multiple strategies of HSP antimicrobial peptide optimization to enhance antimicrobial activity [0.03%]
多种策略优化热休克蛋白抗菌肽以增强其抗菌活性
Xiaozhong Cheng,Yonghuang Zhang,Yan Zhang et al.
Xiaozhong Cheng et al.
Antimicrobial peptides (AMPs) have caught the attention of researchers over the last couple of years due to their unique membrane lytic mechanism for combating antibiotic resistance, which differs from the molecular targets of traditional a...
Altered amino acid levels in young hypopituitarism: impact of NAFLD and insulin resistance [0.03%]
年轻垂体机能不全患者的氨基酸水平改变：非酒精性脂肪肝和胰岛素抵抗的影响
Yuwen Zhang,Jiting Qiu,Shouyue Sun et al.
Yuwen Zhang et al.
Elevated concentrations of amino acids (AAs) are commonly observed in patients with nonalcoholic fatty liver disease (NAFLD). Individuals with hypopituitarism (HP) are at a heightened risk of developing NAFLD due to factors such as visceral...
The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice [0.03%]
反向跨硫代谢途径影响结肠微生物群并导致小鼠结肠炎
Alain P Gobert,Yvonne L Latour,Kara M McNamara et al.
Alain P Gobert et al.
Cystathionine γ-lyase (CTH) is a critical enzyme in the reverse transsulfuration pathway, the major route for the metabolism of sulfur-containing amino acids, notably converting cystathionine to cysteine. We reported that CTH supports gast...
Structure-activity relationship of amino acid analogs to probe the binding pocket of sodium-coupled neutral amino acid transporter SNAT2 [0.03%]
基于SNAT2转运蛋白结构的氨基酸类似物结合位点研究及构效关系分析
Sebastian Jakobsen,Maria Pedersen,Carsten Uhd Nielsen
Sebastian Jakobsen
The sodium-coupled neutral amino acid transporter SNAT2 (SLC38A2) has been shown to have important physiological functions and is implicated in various diseases like cancer. However, few compounds targeting this transporter have been identi...
LLM4THP: a computing tool to identify tumor homing peptides by molecular and sequence representation of large language model based on two-layer ensemble model strategy [0.03%]
基于双层集成模型策略的大语料库语言模型分子和序列表征的肿瘤靶向多肽识别计算工具LLM4THP
Sen Yang,Piao Xu
Sen Yang
Tumor homing peptides (THPs) have a distinctive capacity to specifically attach to tumor cells, providing a promising approach for targeted cancer treatment and detection. Although THPs have the potential for significant impact, their detec...
Tomonori Kimura,Shinsuke Sakai,Masaru Horio et al.
Tomonori Kimura et al.
D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake. Five healthy volunteers were adminis...
A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults [0.03%]
谷氨酰胺补充对成人肠道通透性影响的临床试验系统回顾和荟萃分析
Fatemeh Abbasi,Mohammad Mehdi Haghighat Lari,Gholamreza Reza Khosravi et al.
Fatemeh Abbasi et al.
The gastrointestinal tract's epithelial barrier plays a crucial role in maintaining health. This study aims to investigate the impact of glutamine supplementation on intestinal permeability, considering its importance for immune function an...
Meta-Analysis
Amino acids. 2024 Oct 13;56(1):60. DOI:10.1007/s00726-024-03420-7 2024
Green synthesis of self-oriented flower-like Ag@Ag2O nanostructures functionalized with L-Tryptophan for colorimetric simultaneous determination of ultra-trace level of thiamin and riboflavin [0.03%]
以L-色氨酸功能化自成型花状Ag@Ag2O纳米结构的绿色合成用于肉眼检测低浓度的硫胺素和核黄素
Maryam Abbasi Tarighat,Zahra Khosravani,Gholamreza Abdi
Maryam Abbasi Tarighat
The study focuses on the green synthesis of Ag@Ag2O nanostructures using Padina algae extract and functionalizing them with L-tryptophan to enhance their properties as a colorimetric sensor for simultaneous detection of ultra-trace levels o...