Changes in the concentration of EGFR-mutated plasma DNA in the first hours of targeted therapy allow the prediction of tumor response in patients with EGFR-driven lung cancer [0.03%]
表皮生长因子受体驱动的肺癌患者靶向治疗最初几小时内的表皮生长因子受体突变血浆DNA浓度变化可预测肿瘤反应
Fedor V Moiseyenko,Ekaterina S Kuligina,Albina S Zhabina et al.
Fedor V Moiseyenko et al.
Purpose: This study aimed to analyze changes in the plasma concentration of EGFR-mutated circulating tumor DNA (ctDNA) occurring immediately after the start of therapy with EGFR tyrosine kinase inhibitors (TKIs). ...
CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis [0.03%]
Circular RNA-PVT1通过miR-24-3p/KLF8轴促进骨肉瘤细胞的增殖和化学抗性
Bin Wang,Lifang Yan,Weihong Shi et al.
Bin Wang et al.
Objective: To investigate the regulatory effect and mechanism of circular RNA PVT1 (circPVT1) in proliferation and chemoresistance of osteosarcoma (OS) cells. ...
Real-world data on the efficacy and safety of adjuvant chemotherapy in Japanese patients with a high-risk of gastrointestinal stromal tumor recurrence [0.03%]
日本高危胃肠间质瘤复发患者的辅助化疗疗效和安全性的真实世界数据
Yuki Ushimaru,Tsuyoshi Takahashi,Kiyokazu Nakajima et al.
Yuki Ushimaru et al.
Background: Complete surgical resection is the only treatment for resectable gastrointestinal stromal tumors (GISTs). Three-year adjuvant chemotherapy (AC) is recommended for patients with high-risk GISTs. However, there ...
Correction to: Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2 [0.03%]
日本临床肿瘤学会儿童、青少年及青年人群癌症患者生育力保存临床实践指南(2017年版)的更正：第二部分
Akiko Tozawa,Fuminori Kimura,Yasushi Takai et al.
Akiko Tozawa et al.
C-reactive protein kinetics to predict recurrence of high-risk renal cell carcinoma after radical surgery [0.03%]
术后血清超敏C-反应蛋白动力学预测高危肾癌复发的价值
Yudai Ishiyama,Tsunenori Kondo,Hiroki Ishihara et al.
Yudai Ishiyama et al.
Background: With new options in adjuvant settings, clinical biomarkers to predict recurrence after radical surgery for high-risk renal cell carcinoma (hrRCC) are in need but are scarcely investigated. We aimed to verify t...
Integrative analysis identifies activated anti-tumor immune microenvironment in lung metastasis of pancreatic cancer [0.03%]
整合分析发现胰腺癌肺转移灶中抗肿瘤免疫微环境被激活
Toshihide Sasaki,Satoshi Nishiwada,Kenji Nakagawa et al.
Toshihide Sasaki et al.
Background: Although the prognosis of patients experiencing recurrences after surgery for pancreatic cancer is extremely poor, patients who develop recurrence in the lung have a better prognosis compared to other types of...
Impact of carcinoma in situ on the outcome of intravesical Bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer: a comparative analysis of large real-world data [0.03%]
原位癌对非肌层浸润性膀胱癌卡介苗灌注疗效影响的实证研究：大样本回顾分析
Ryotaro Tomida,Makito Miyake,Ryoei Minato et al.
Ryotaro Tomida et al.
Background: This study investigated the clinical impact of carcinoma in situ (CIS) in intravesical Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle-invasive bladder cancer (NMIBC). ...
The adenosine-A2a receptor regulates the radioresistance of gastric cancer via PI3K-AKT-mTOR pathway [0.03%]
腺苷A2a受体通过PI3K-AKT-mTOR信号通路调节胃癌的放射抵抗性
Guihong Liu,Song Yang,Yang Liu et al.
Guihong Liu et al.
Background: Radiotherapy is a key strategy in gastric cancer (GC) treatment. However, radioresistance remains a serious concern. It is unclear whether the accumulation of adenosine A2a receptor (ADO-A2aR) is related to ra...
Circulating tumor cells may serve as a supplement to RECIST in neoadjuvant chemotherapy of patients with locally advanced breast cancer [0.03%]
循环肿瘤细胞可作为新辅助化疗中局部晚期乳腺癌患者评估的RECIST补充指标
Ji Wang,Xinyang Wang,Rui Chen et al.
Ji Wang et al.
Background: Circulating tumor cells (CTCs) have been shown to be associated with the response to neoadjuvant chemotherapy (NCT) and the prognosis of locally advanced breast cancer (LABC) patients. Our study aimed to inves...
Intensity-modulated radiation therapy for prostate cancer after rectal surgery: a single hospital long-term safety analysis [0.03%]
术后直肠切除患者的前列腺癌调强放疗的长期安全性分析
Shuang Zhang,Kiyonao Nakamura,Rihito Aizawa et al.
Shuang Zhang et al.
Background: Radiotherapy is a treatment option for prostate cancer patients after rectal surgery; however, the toxicity profile of radiotherapy for such patients has not been elucidated. This study aimed to evaluate the l...