Deubiquitinases as prognostic biomarker and potential drug target for gynecological cancers [0.03%]
脱泛素酶作为妇科肿瘤预后生物标志物和潜在药物作用靶点的研究进展
Mavika Kondapally,Anubha Dey,Abhiram Matta et al.
Mavika Kondapally et al.
Background: To develop Deubiquitinase-Associated Signatures (DAS) to predict the prognosis of gynecological cancer patients. Methods: U...
Future perspective of clinical usefulness of metabolic and mitochondrial heterogeneity in triple-negative breast cancers [0.03%]
三阴性乳腺癌代谢和线粒体异质性的临床意义的未来展望
Jing Li,Ravi Velaga,Yuko Takano et al.
Jing Li et al.
Triple-negative breast cancer (TNBC) is best characterized by high aggressiveness and significant biological heterogeneity. Although the current TNBC clinical trials include genomic biomarkers to stratify treatment arms, they are still limi...
Lung immune prognostic index as a biomarker for predicting the benefit of immune checkpoint inhibitor plus chemotherapy in older patients with non-small cell lung cancer: a secondary analysis of the NEJ057 study [0.03%]
肺癌免疫预后指数作为老年非小细胞肺癌患者免疫检查点抑制剂联合化疗疗效预测生物标志物的验证性分析：NEJ057研究的事后分析
Takehiro Tozuka,Yoko Tsukita,Kohei Kushiro et al.
Takehiro Tozuka et al.
Background: The survival benefit of combining chemotherapy (chemo) with immune checkpoint inhibitors (ICIs) in older patients with advanced non-small cell lung cancer (NSCLC) remains unclear. We evaluated the lung immune ...
Evaluation of factors associated with clinically problematic hiccups in cisplatin-containing treatment with dexamethasone and neurokinin 1 receptor antagonists [0.03%]
地塞米松和神经激肽受体拮抗剂联合顺铂导致的临床问题性打嗝的影响因素分析
Yoshitaka Saito,Yoh Takekuma,Jun Sakakibara-Konishi et al.
Yoshitaka Saito et al.
Background: Chemotherapy-induced hiccups are one of the frequently appearing adverse events. Previous reports have suggested that cisplatin (CDDP) combined with dexamethasone and neurokinin 1 (NK1) receptor antagonists is...
Real-life observational study on niraparib in older patients with primary tubo-ovarian cancer: a focus on safety and efficacy [0.03%]
尼拉帕利治疗初治高级别浆液性或子宫内膜样卵巢癌、输卵管癌或腹膜癌老年患者的真实世界观察研究：重点关注疗效和安全性
Adriana Ionelia Apostol,Matteo Bruno,Carolina Maria Sassu et al.
Adriana Ionelia Apostol et al.
Background: Niraparib is approved for maintenance treatment of tubo-ovarian cancer patients, but data on older patients are limited. This retrospective study evaluated its safety and efficacy in primary advanced tubo-ovar...
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2024 for the treatment of colorectal cancer [0.03%]
2024年日本大肠癌学会(colorectal cancer, JSCCR)结直肠癌治疗指南
Yusuke Kinugasa,Kay Uehara,Kensei Yamaguchi et al.
Yusuke Kinugasa et al.
The number of deaths from colorectal cancer in Japan continues to rise, with over 50,000 deaths recorded in 2018. In the 2024 edition, revisions to all aspects of treatment were undertaken, with corrections and additions made based on knowl...
Risk of severe infections in patients with triple-negative breast cancer treated with atezolizumab plus nab-paclitaxel: a real-world, postmarketing database study in Japan [0.03%]
阿特朱单抗联合白蛋白结合型紫杉醇治疗三阴性乳腺癌的严重感染风险：日本上市后数据库的真实世界研究
Akinori Yuri,Sayuri Nakane,Yuki Miyano et al.
Akinori Yuri et al.
Background: An increased risk of infection has been suggested for patients with triple-negative breast cancer (TNBC) treated with atezolizumab plus nab-paclitaxel based on the IMpassion130 trial. ...
Elevated proportion of eosinophils predicts immune-related adverse events and improved survival in patients with gastric cancer treated with nivolumab [0.03%]
富嗜酸性粒细胞预测胃癌患者纳武利尤单抗治疗的免疫相关不良事件及更好的预后
Sohei Matsumoto,Hiroshi Nakade,Tomohiro Kunishige et al.
Sohei Matsumoto et al.
Background: Immune checkpoint inhibitors (ICIs) have improved treatment outcomes for gastric cancer. However, immune-related adverse events (irAEs) pose a major challenge. This study aimed to identify predictive factors f...
Toward safe clinical deployment of remote robotic surgery in Japan: five-year validation of the hinotori™ system using 5G wireless communication [0.03%]
日本远程机器人手术hinotori系统五年验证：面向临床应用阶段的安全保障研究使用5G无线通信技术开展的日本远程手术系统的五年验证研究
Takuto Hara,Yoshifumi Morihiro,Yuki Horise et al.
Takuto Hara et al.
Remote robotic-assisted surgery (RRAS), a form of telesurgery, offers a potential solution to Japan's surgeon shortage and regional disparities in care. Despite advances in robotic systems and modern communication technologies, including bo...