The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis [0.03%]
近期接受过化疗的中性粒细胞减少症患者发生败血症时其严重程度对死亡率的影响
Shreyas Shirodkar,Saad Javaid,Jennifer Collins et al.
Shreyas Shirodkar et al.
Background: Sepsis and septic shock are major causes of non-relapse mortality in cancer patients, with chemotherapy-induced neutropenia increasing infection risk. The prognostic impact of neutropenia remains unclear acros...
Long-term progression-free survivors ("super responders") to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s) [0.03%]
奥拉帕利维持治疗复发性卵巢癌长期无进展生存者（超级应答者）的多中心真实世界研究(KCOG-G2101s)
Naho Fukuda,Tsuyoshi Takashima,Hidekatsu Nakai et al.
Naho Fukuda et al.
Background: PARP inhibitors have been shown to improve progression-free survival in patients with recurrent ovarian cancer. However, their potential for long-term response and cure remains unclear in real-world practice. ...
Impact of baseline regular magnesium oxide administration on chemotherapy-induced constipation during cisplatin-containing treatment [0.03%]
含顺铂方案中常规氧化镁预防化疗相关性便秘的临床研究
Yoshitaka Saito,Yoh Takekuma,Jun Sakakibara-Konishi et al.
Yoshitaka Saito et al.
Purpose: Chemotherapy-induced constipation frequently occurs with cisplatin-containing treatments, partly because of concomitant neurokinin 1 and serotonin 3 receptor antagonists. We have clinically observed that patients...
Radiotherapy with or without chemotherapy for T2N0 hypopharyngeal cancer: an analysis of the head and neck cancer registry of Japan [0.03%]
日本头颈癌登记处T2N0下咽癌放射治疗联合或不联合化疗的分析研究
Ari Nishimura,Naoki Fukuda,Daisuke Kawakita et al.
Ari Nishimura et al.
Purpose: This retrospective study compared the outcomes of radiotherapy (RT) and chemoradiotherapy (CRT) in patients with T2N0 hypopharyngeal cancer. Meth...
Prognostic and clinicopathological implications of mismatch-repair deficiency and MLH1 promoter methylation status in endometrial carcinoma [0.03%]
子宫内膜癌错配修复缺陷和MLH1启动子甲基化的预后及临床病理意义
Mayuko Goda,Gou Yamamoto,Katsuya Iuchi et al.
Mayuko Goda et al.
Objective: The prevalence of MSI-H and MLH1 promoter hypermethylation (MLH1-PHM) as well as Lynch syndrome in Japanese patients with endometrial cancer (EC) has not been fully revealed. There is also a recent report that ...
Real-world experience of circulating tumor DNA testing in resectable colorectal cancer: a Japanese single-institution observational study [0.03%]
结直肠癌可切除病例中循环肿瘤DNA检测的现实世界研究——日本单中心观察性研究
Yuko Fukumoto,Kozo Kataoka,Yoshiko Muroi et al.
Yuko Fukumoto et al.
Background: Assessment of molecular residual disease (MRD) using circulating tumor DNA (ctDNA) is a powerful prognostic tool for detecting postoperative recurrence in colorectal cancer (CRC). However, ctDNA-based MRD test...
PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs in Japan; encorafenib for colorectal cancer, daratumumab for multiple myeloma, repotrectinib for NTRK-fusion positive solid tumors, and venetoclax for leukemia [0.03%]
日本PMDA关于抗癌药物审批及使用注意事项修订的监管更新；用于结直肠癌的恩考芬尼，用于多发性骨髓瘤的达雷木单抗，用于NTRK融合阳性实体肿瘤的瑞波替尼和用于白血病的维奈托克
Noriomi Matsumura,Masaki Mandai
Noriomi Matsumura
Microflora: a promising potential in the diagnosis and treatment of non-small cell lung cancer [0.03%]
微生态：在非小细胞肺癌诊疗中的一片蓝海？
Longfei Wang,Yange Chi,Min Zhang et al.
Longfei Wang et al.
The incidence and mortality of non-small cell lung cancer (NSCLC) remain high in China. Recently, several studies have shown a complex correlation between microflora and NSCLC. Compared to patients with healthy/benign lung disease, patients...
Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies [0.03%]
子宫内膜癌筛查的新进展：现有方法和新兴技术的全面综述
Mahsa Fatahichegeni,Zahra Haji Ghasem Sharbatdar,Mohammad Amin Ansarian
Mahsa Fatahichegeni
Endometrial cancer represents a major global health concern, with rising incidence particularly in developed countries despite declining mortality rates. This comprehensive review examines the evolution of endometrial cancer screening techn...
Intraperitoneal nivolumab for malignant ascites in patients with advanced gastrointestinal or pancreaticobiliary tract cancer [0.03%]
腹腔内注射纳武单抗治疗消化系统或胆道恶性肿瘤晚期患者癌性腹水的安全性和有效性研究
Hsiu-Tzu Wang,Yung-Luen Yu,Wen-Jyi Lo et al.
Hsiu-Tzu Wang et al.
Background: Malignant ascites occur in 10-15% of patients with gastrointestinal tract cancers. The abundance of immune cells in the peritoneum and ascitic fluid, along with the immunosuppressive environment created by can...