Predicting congenital hypothyroidism in newborns with complex risk profiles by using thyroid-stimulating hormone variations across serial dried blood spots [0.03%]
基于甲状腺刺激激素的变化预测复杂风险剖面新生儿的先天性甲状腺功能减退症
Laura Cappelletti,Amy Gaviglio,Sara Moggia et al.
Laura Cappelletti et al.
Objectives: Newborn screening for congenital hypothyroidism (CH) relies on thyroid-stimulating hormone (TSH) levels from dried blood spots (DBS). We investigated whether incorporating TSH variation across serial DBS could...
Utility of flow cytometric PAX5 protein detection for the diagnosis of B-cell acute lymphoblastic leukemia [0.03%]
流式细胞仪检测PAX5蛋白在B淋巴细胞急性淋巴细胞白血病诊断中的应用价值
Tanintorn Pootrakul,Burana Khiankaew,Paisarn Boonsakan et al.
Tanintorn Pootrakul et al.
Objectives: Accurate B-lineage assignment in acute leukemia is critical for therapeutic decisions. While nuclear expression of PAX5 protein (nPAX5) is a highly reliable marker for B-cell differentiation, its conventional ...
Cardiac troponin T measurement following cardiac surgery in children with congenital heart defects predicts adverse outcomes [0.03%]
先天性心脏病儿童心脏手术后测定心肌抑制素T可预测预后不良事件
Giuseppe Isgrò,Alessandro Giamberti,Elena Costa et al.
Giuseppe Isgrò et al.
Objectives: Testing for high-sensitivity cardiac troponin (hs-cTn) often occurs following pediatric cardiac surgery, although evidence regarding its utility remains heterogeneous. This study aimed to assess the prognostic...
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasma [0.03%]
基于同位素稀释液相色谱串联质谱的候选参考测量程序，用于定量测定人血清和血浆中雄烯二酮含量
Lea Lewin,Michael Stadlmeier,Neeraj Singh et al.
Lea Lewin et al.
Objectives: 5α-dihydrotestosterone (DHT) is a potent androgen, related to male sexual development and irreversibly synthesized from testosterone via 5α-reductase. Dysfunctions in the 5α-reductase system, locally or glo...
Biological variation and inter-relation between key calcium homeostasis biomarkers [0.03%]
钙稳态生物标志物的生物学变异及相互关系
Nora Alicia Guldhaug,Eirik Åsen Røys,Kristin Viste et al.
Nora Alicia Guldhaug et al.
Objectives: This study aims to explore the biological variability of calcium homeostasis biomarkers, including calcium, phosphate, magnesium, 25-OH vitamin D, 1,25-OH vitamin D, and parathyroid hormone (PTH), and to devel...
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of voriconazole in human serum and plasma [0.03%]
基于同位素稀释液相色谱串联质谱法定量人血清和血浆伏立康唑候选参考测量程序
Marie Kubicova,Anett Engel,Lena Ruhe et al.
Marie Kubicova et al.
Objectives: Voriconazole is an antifungal agent measured in serum and plasma for therapeutic drug monitoring. This study aimed to develop a robust isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/...
Comparison of six serum analyte workflows using routine liquid chromatography-tandem mass spectrometry methods at multiple laboratories with the Cobas i 601 analyzer, an automated mass spectrometry system [0.03%]
六种血清分析物的工作流程在多个实验室的常规液相色谱-串联质谱法与Cobas i 601分析仪（自动质谱系统）的比较研究
Pieter Vermeersch,Robert de Jonge,Takamaro Miyazawa et al.
Pieter Vermeersch et al.
Objectives: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers substantial analytical advantages over traditional immunoassay methods, including greater specificity and robustness. Conventional LC-MS/MS meth...
An isotope dilution-liquid chromatography tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone in human serum and plasma [0.03%]
人血清和血浆中脱氢表雄酮定量候选参考测量程序的研究：基于同位素稀释液相色谱-串联质谱法
Lea Lewin,Michael Stadlmeier,Neeraj Singh et al.
Lea Lewin et al.
Objectives: Dehydroepiandrosterone (DHEA) is a steroid prohormone and important precursor for estrogen and testosterone biosynthesis. For differential diagnosis of sexual development disorders (e.g., polycystic ovary synd...
Mario Plebani,Michel Langlois,Alexander von Meyer et al.
Mario Plebani et al.
The Meeting on Science, Quality and Value of Laboratory Medicine was held on 11 December 2025 in Padua, immediately preceding the 7th European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Conference on the Preanalytical P...
Falsely elevated serum estradiol levels measured by Abbott estradiol immunoassay in women taking abemaciclib [0.03%]
阿贝西利对其它厂家雌二醇检测方法的影响研究
Ivana Lapić,Saša Kralik Oguić,Tajana Silovski et al.
Ivana Lapić et al.