Biological variability of transthyretin in patients with transthyretin cardiac amyloidosis: implications for therapy monitoring [0.03%]
转甲状腺素蛋白心脏淀粉样变患者中transthyretin的生物变异性和治疗监测的意义
Giuseppe Vergaro,Veronica Musetti,Francesca Samà et al.
Giuseppe Vergaro et al.
Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthood [0.03%]
从婴儿期到儿童期和成人期的年龄和性别特异性11氧代雄激素参考区间
Robert Zeidler,Friederike Wagner,Uta Ceglarek et al.
Robert Zeidler et al.
Objectives: The adrenal glands are the main source of 11-oxygenated androgens (11-OAs), including the potent 11-ketotestosterone (11-KT) and the weaker metabolites 11β-hydroxyandrostenedione (11-OHA4), 11β-hydroxytestos...
From ordering to interpretation: a comprehensive framework for laboratory test indications [0.03%]
从申请到解读：实验室检验指征的全面框架
Jasmin Weninger,Thomas Streichert,Abdurrahman Coskun et al.
Jasmin Weninger et al.
Objectives: Clinical intent for laboratory testing ("indication") is rarely recorded in structured form, limiting contextual interpretation, auditability, and utilization stewardship. We developed a comprehensive, and cli...
Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damage [0.03%]
抗磷脂idylserine/凝血酶原自身抗体定义了高风险抗磷脂综合征谱系与器官损害相关联
Ariela Hoxha,Giovanni Gobbo,Sabrina Gavasso et al.
Ariela Hoxha et al.
Objectives: Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are promising non-criteria aPLs associated with antiphospholipid syndrome (APS) manifestations. Their influence on long-term outcomes and damage remains u...
Blood biomarkers in neurodegenerative diseases: pre-analytical, analytical, and post-analytical challenges [0.03%]
神经退行性疾病血液生物标志物的前分析、分析和后分析挑战
Constance Delaby,Sylvain Lehmann
Constance Delaby
Recent advances in blood-based biomarkers for neurodegenerative diseases present promising opportunities for earlier diagnosis and more effective disease monitoring. However, challenges in standardizing sample collection, processing protoco...
Sveva Stangalini,Sara Sacchetti,Paolo Tillio et al.
Sveva Stangalini et al.
Objectives: Clinical laboratories play a vital role in healthcare but are also among the most resource-intensive hospital units. High energy and water consumption, extensive use of single-use plastics, and the generation ...
Implementation of AI systems in the clinical laboratory: insights from an expert survey and recommendations for best practice [0.03%]
基于专家调查的实验室临床实验中AI系统的实施及最佳应用建议
He S Yang,Hikmet Can Çubukçu,Fabio Del Ben et al.
He S Yang et al.
Objectives: Despite growing interest in artificial intelligence (AI) and machine learning (ML), many laboratory professionals lack experience with developing in-house AI systems or implementing those supplied by external ...
Familial erythrocytosis and phenotypic heterogeneity associated with different defects in alpha globin genes: a significant new case of Hb Wroclaw (α88(F9) Ala>Glu; HBA1: c.266C>A) [0.03%]
与不同类型的alpha珠蛋白基因缺陷相关的家族性红细胞增多症和表型异质性：HBA1：c。266C> A（Hb Wroclaw（α88（F9）Ala>Glu）的显著新病例
Valentina Carrai,Cristina Giubbilei,Tiziana Biagioli et al.
Valentina Carrai et al.
Laboratory solution to diagnose and monitor atypical IgG4-mediated anti-GBM disease [0.03%]
实验室解决方案用于诊断和监测非典型IgG4介导的抗GBM疾病
Joannes F M Jacobs,Annechien J A Lambeck,Rosa G M Lammerts et al.
Joannes F M Jacobs et al.
Objectives: Diagnosing atypical IgG4-mediated anti-glomerular basement membrane (anti-GBM) disease is challenging because conventional serological assays poorly detect IgG4 antibodies. Here we study which commercial assay...
Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serum [0.03%]
储存条件对脑脊液和血清中NSE、S100和B2M稳定性的效果研究
Natalia García-Sancha,Juan Valencia,Simón Gundín et al.
Natalia García-Sancha et al.
Objectives: The reliability of cerebrospinal fluid (CSF) and serum biomarkers depends on sample integrity, which is strongly influenced by storage conditions. While -80 °C is considered the gold standard for long-term pr...