An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of testosterone in human serum and plasma [0.03%]
基于同位素稀释液相色谱-串联质谱的睾酮定量候选参考测量程序：人血清和血浆中的睾酮定量方法研究
Elie Fux,Rupert Schmid,Neeraj Singh et al.
Elie Fux et al.
Objectives: This study presents a candidate reference measurement procedure (RMP) for testosterone quantification in human serum and plasma, utilizing isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC...
Stability of different biochemical parameters in pooled left-over sera stored for 14 days after pooling either at room temperature or at 2-10 °C [0.03%]
储存14天后不同生化参数在混样剩余血清中的稳定性研究——混样后分别于室温及2~8℃保存
Maja Zabel,Thomas Perkmann,Patrick Mucher et al.
Maja Zabel et al.
Objectives: This stability study aimed to evaluate the stability of 48 biochemical analytes in pooled serum samples derived from leftover sera over 14 days at room temperature (RT) and at 2-10 °C, and to assess the consi...
99th percentile upper reference limits of the 5th and 6th generation Elecsys® cardiac troponin T high-sensitivity assays in a single cohort of healthy blood donors [0.03%]
同一健康献血者队列中第五代和第六代Elecsys®高敏心肌肌钙T测定的第99百分位数上限参考值区间的研究
Margot Egger,Philipp Schmid,Christine Kimbacher et al.
Margot Egger et al.
The ARRplus: a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronism [0.03%]
基于肾素依赖和性别特异醛固酮切点的原发性醛固酮增多症筛查模型（ARRplus）
Sybille Fuld,Jun Yang,Georgiana Constantinescu et al.
Sybille Fuld et al.
Objectives: Screening for primary aldosteronism (PA) using the aldosterone:renin ratio (ARR) has suboptimal diagnostic accuracy, particularly in females. We assessed whether accuracy could be improved using sex-specific r...
Personalized reference intervals based on biological variation for serum bone turnover markers in healthy older adults [0.03%]
基于生物学变异的健康老年人血清骨转换标志物个人化参考区间
Ye Qin,Lei Zhao,Runqing Mu et al.
Ye Qin et al.
Objectives: The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly is constrained by the absence of personalized reference intervals (prRI) based on biological variation (BV). ...
Optimizing diagnostic thresholds of total vitamin B12 (B12) for identifying cobalamin deficiency in adults with macrocytic anemia [0.03%]
优化成人巨幼细胞性贫血患者血清维生素B12诊断界值筛查钴胺素缺乏
Michela Pelloso,Bruno Mario Cesana,Giulia Musso et al.
Michela Pelloso et al.
Objectives: Identifying individuals with vitamin B12 (B12) deficiency is challenging due to poor harmonization across total B12 assays. To establish clinically meaningful thresholds for the Roche assay, we characterized B...
Analytical performance of the Roche Elecsys TnT hs Gen 6 immunoassay [0.03%]
罗氏试剂Cobas electroTnT hs Gen 6检测的性能评估分析
Marco Tosi,Laura Pighi,Claudia Lo Cascio et al.
Marco Tosi et al.
Objectives: The acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide, with timely diagnosis being critical for improving outcomes. Since high-sensitivity cardiac troponin (hs-cTn) assays h...
Christa M Cobbaert,Nicolaas J M van Neer,Nina M Diederiks et al.
Christa M Cobbaert et al.
Lipoprotein(a) (Lp(a)) has the reputation of being the most misunderstood metric in laboratory medicine. The unique apolipoprotein(a) (apo(a)) in Lp(a) is very heterogenous, the kringle IV domain of apo(a) being formed by 12-50 kringles due...