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Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features [0.03%] 源自牛超长CDR-H3的knob结构表位产生强大的TNF-α中和并能够生成具有增强特征的新adalimumab抗体构型
Paul Arras,Jasmin Zimmermann,Britta Lipinski et al. Paul Arras et al.
In this work we have generated cattle-derived chimeric ultralong CDR-H3 antibodies targeting tumor necrosis factor α (TNF-α) via immunization and yeast surface display. We identified one particular ultralong CDR-H3 paratope that potently ...