CCM scaffolds at the frontier of biomechanics: their roles in vascular physiology and disease [0.03%]
共聚合物支架在生物力学领域的前沿：其在血管生理学和疾病中的作用
Claudia Jasmin Rödel,Salim Abdelilah-Seyfried
Claudia Jasmin Rödel
Cerebral cavernous malformation (CCM) is a genetic vascular disorder arising from endothelial dysfunction, affecting the microvasculature of the central nervous system. Patients with mutations in any of three CCM genes may suffer from neuro...
Functional interaction of HINT1 with MRTF-A: complex formation, protein stabilisation and transcriptional repression [0.03%]
HINT1与MRTF-A的功能互作：复合物形成、蛋白质稳定及转录抑制作用
Marianne Stognienko,Guido Posern
Marianne Stognienko
Histidine triad nucleotide-binding protein 1 (HINT1) is a small and evolutionarily conserved HIT family protein with putative tumor suppressor function. It has been implicated in the negative regulation of several transcription factors, but...
Tanja Maritzen,Volker Haucke
Tanja Maritzen
Editorial
Biological chemistry. 2026 Jul 27. DOI:10.1515/hsz-2026-0171 2026
Learning from trypsin(ogen) structures: conformational flexibility and functional disorder [0.03%]
从胰蛋白酶(原)结构学习到的成果：构象灵活性和功能紊乱
Milton T Stubbs
Milton T Stubbs
Our understanding of trypsin, its zymogenicity and its inhibition is intimately intertwined with the history of biochemistry. Early structural studies revealed its close relationship to chymotrypsin, with its active site triad, oxyanion hol...
On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes [0.03%]
关于细胞毒淋巴细胞致死小组颗粒酶的结构和功能
José Luis Gardeazábal-Torbado,Eva Estébanez-Perpiñá,Pablo Fuentes-Prior
José Luis Gardeazábal-Torbado
Granzymes are a family of trypsin-like serine proteinases (TLSP) produced by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. They play critical roles in immune defense by inducing diverse forms of programmed cell death (e.g., ...
Actin-related and actin-like proteins: functional diversification of the actin-fold [0.03%]
与肌动蛋白相关的和类似肌动蛋白的蛋白质：肌动蛋白折叠的功能多样化
Abdul Rahman,Anja Marquardt,Johannes N Greve
Abdul Rahman
Actin-related proteins (Arps) and actin-like proteins constitute a subfamily of actin-fold proteins that are evolutionarily and structurally related to conventional actin but functionally distinct. While actin is defined by its ability to f...
Actin scaffolds as organizers of presynaptic function, assembly and plasticity across species [0.03%]
裂隙蛋白骨架在跨物种的突触前功能、组装和可塑性中的作用
Stephan J Sigrist,Astrid G Petzoldt
Stephan J Sigrist
The presynapse is a highly specialized neuronal compartment whose organizational core, the active zone, coordinates the precisely regulated neurotransmitter release. The function, assembly, maturation and remodeling of presynapses are funda...
Neuronal membrane organization by the submembranous spectrin-ankyrin scaffold: evolution, specialization and disease [0.03%]
神经膜骨架蛋白(神经内板骨架蛋白-锚蛋白支架)的组织作用：进化、特化与疾病
Maximilian Goy,Jan Pielage
Maximilian Goy
Neuronal function relies on precise compartmentalization into dendritic, somatic, axonal, and synaptic domains that require specialized cellular architectures. Axons, in particular, can extend over extraordinary distances while preserving s...
Thilo Speckmann,Judith Saurenbach,Annette Schürmann
Thilo Speckmann
Golgi-associated membrane scaffolds, or tethers, have broad roles in membrane-bound protein and lipid trafficking and in maintaining Golgi architecture. Accordingly, they exert strong influence over cellular development, signalling, cargo m...
Clotilde Charrier,Sascha Mrachacz,Sabrina Schulze et al.
Clotilde Charrier et al.
Proteins of the Ras-family are guanine nucleotide binding proteins (GNBPs) involved in a variety of fundamental cellular processes, including cell proliferation, cell differentiation, cytoskeleton dynamics, vesicular processes and intracell...