Robert Pedley,Andrew P Gilmore
Robert Pedley
Cell division is a period of danger for cells, as inaccurate segregation of chromosomes can lead to loss of cell viability or aneuploidy. In order to protect against these dangers, cells ultimately initiate mitochondrial apoptosis if they a...
Adenovirus-mediated expression of vascular endothelial growth factor-a potentiates bone morphogenetic protein9-induced osteogenic differentiation and bone formation [0.03%]
腺病毒介导的血管内皮生长因子A表达可增强骨形态发生蛋白9诱导的成骨分化和骨形成
Chang-Jun Pi,Kai-Lu Liang,Zhen-Yong Ke et al.
Chang-Jun Pi et al.
Mesenchymal stem cells (MSCs) are suitable seed cells for bone tissue engineering because they can self-renew and undergo differentiation into osteogenic, adipogenic, chondrogenic, or myogenic lineages. Vascular endothelial growth factor-a ...
Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance [0.03%]
调控饮食肥胖小鼠和胰岛素抵抗小鼠的代谢作用机制
Opeolu O Ojo,Dinesh K Srinivasan,Bosede O Owolabi et al.
Opeolu O Ojo et al.
The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observations by investigating the molec...
Regulation of necroptosis signaling and cell death by reactive oxygen species [0.03%]
活性氧对坏死性凋亡信号及细胞死亡的调控作用
Simone Fulda
Simone Fulda
Necroptosis has recently been identified as an alternative form of programmed cell death that is characterized by defined molecular mechanisms. Reactive oxygen species (ROS) are involved in the regulation of numerous signaling pathways, as ...
iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry [0.03%]
iBH3：通过流式细胞术测定原代组织中凋亡启动的简便可修复的BH3谱分析法
Jeremy Ryan,Joan Montero,James Rocco et al.
Jeremy Ryan et al.
Dysregulation of the mitochondrial pathway of apoptosis, controlled by the BCL-2 family of proteins, leads to disease states including cancer. Rapid analysis of a cell's dependency on the BCL-2 family of proteins is hindered by the complex ...
The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes [0.03%]
近期遗传学进展对长QT综合征疾病机制的影响
Stephen C Harmer,Andrew Tinker
Stephen C Harmer
Long QT syndrome refers to a characteristic abnormality of the electrocardiogram and it is associated with a form of ventricular tachycardia known as torsade-de-pointes and sudden arrhythmic death. It can occur as part of a hereditary syndr...
Mackenzie K Herroon,Rajgopal Sharma,Erandi Rajagurubandara et al.
Mackenzie K Herroon et al.
Collagenolytic activity of cathepsin K is important for many physiological and pathological processes including osteoclast-mediated bone degradation, macrophage function and fibroblast-mediated matrix remodeling. Here, we report application...
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors [0.03%]
探究分泌弹性蛋白酶样丝氨酸蛋白酶5(KLK5)活性位点的底物特异性引导新型肽类底物和抑制剂的设计
Simon J de Veer,Joakim E Swedberg,Maria Brattsand et al.
Simon J de Veer et al.
Kallikrein-related peptidase 5 (KLK5) is a promising therapeutic target in several skin diseases, including Netherton syndrome, and is emerging as a potential target in various cancers. In this study, we used a sparse matrix library of 125 ...
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2 [0.03%]
鉴定蛋白磷酸酶2A作为富含亮氨酸重复激酶2的相互作用蛋白
Panagiotis S Athanasopoulos,Wright Jacob,Sebastian Neumann et al.
Panagiotis S Athanasopoulos et al.
Mutations in the gene coding for the multi-domain protein leucine-rich repeat kinase 2 (LRRK2) are the leading cause of genetically inherited Parkinson's disease (PD). Two of the common found mutations are the R1441C and G2019S. In this stu...
Human CYP27A1 catalyzes hydroxylation of β-sitosterol and ergosterol [0.03%]
人CYP27A1催化β-谷甾醇和麦角固醇羟基化反应
Maximilian Ehrhardt,Adrian Gerber,Josef Zapp et al.
Maximilian Ehrhardt et al.
β-Sitosterol and ergosterol are the equivalents of cholesterol in plants and fungi, respectively, and common sterols in the human diet. In the current work, both were identified as novel CYP27A1 substrates by in vitro experiments applying ...