Type II transmembrane serine proteases as potential targets for cancer therapy [0.03%]
II型跨膜丝氨酸蛋白酶作为癌症治疗的潜在靶点
Andrew S Murray,Fausto A Varela,Karin List
Andrew S Murray
Carcinogenesis is accompanied by increased protein and activity levels of extracellular cell-surface proteases that are capable of modifying the tumor microenvironment by directly cleaving the extracellular matrix, as well as activating gro...
The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2 [0.03%]
完整的Kunitz结构域可保护淀粉样前体蛋白免遭matriptase-2切割
Anna-Madeleine Beckmann,Konstantin Glebov,Jochen Walter et al.
Anna-Madeleine Beckmann et al.
Proteolytic processing of the amyloid precursor protein (APP) leads to amyloid-β (Aβ) peptides. So far, the mechanism of APP processing is insufficiently characterized at the molecular level. Whereas the knowledge of Aβ generation by sev...
Insung Na,Min J Kong,Shelby Straight et al.
Insung Na et al.
Cardiac troponin is a dynamic complex of troponin C, troponin I, and troponin T (TnC, TnI, and TnT, respectively) found in the myocyte thin filament where it plays an essential role in cardiac muscle contraction. Mutations in troponin subun...
Joel S Riley,Stephen W G Tait
Joel S Riley
Since entering our cells in an endosymbiotic event one billion years ago, mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. Given this critical role in cellular homeostasi...
Elena Arutyunova,Cameron C Smithers,Valentina Corradi et al.
Elena Arutyunova et al.
Rhomboids are ubiquitous intramembrane serine proteases involved in various signaling pathways. While the high-resolution structures of the Escherichia coli rhomboid GlpG with various inhibitors revealed an active site comprised of a serine...
Endocytosis of pro-inflammatory cytokine receptors and its relevance for signal transduction [0.03%]
促炎症细胞因子受体的内吞作用及其对信号转导的影响
Heike M Hermanns,Julia Wohlfahrt,Christine Mais et al.
Heike M Hermanns et al.
The pro-inflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) are key players of the innate and adaptive immunity. Their activity needs to be tightly controlled to allow the initiation of an appro...
Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling [0.03%]
颗粒酶B通过破坏表皮生长因子受体（EGFR）介导的信号转导抑制角质形成细胞迁移
Yulia Merkulova,Yue Shen,Leigh G Parkinson et al.
Yulia Merkulova et al.
Chronic non-healing wounds including diabetic, venous, and decubitus skin ulcers are currently lacking effective therapies. Non-healing diabetic ulcers can lead to amputations as progress into a highly chronic state before detection and exi...
Yi Hui Yee,Stephen Jun Fei Chong,Shazib Pervaiz
Yi Hui Yee
Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its c...
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction [0.03%]
活性氧(ROS)在脂肪细胞功能与病理中的双重作用
José Pedro Castro,Tilman Grune,Bodo Speckmann
José Pedro Castro
White adipose tissue (WAT) is actively involved in the regulation of whole-body energy homeostasis via storage/release of lipids and adipokine secretion. Current research links WAT dysfunction to the development of metabolic syndrome (MetS)...
A systematic comparison of two new releases of exome sequencing products: the aim of use determines the choice of product [0.03%]
对两种新的外显子组测序产品的系统比较：使用目的决定产品选择
Janine Altmüller,Susanne Motameny,Christian Becker et al.
Janine Altmüller et al.
We received early access to the newest releases of exome sequencing products, namely Agilent SureSelect v6 (Agilent, Santa Clara, CA, USA) and NimbleGen MedExome (Roche NimbleGen, Basel, Switzerland), and we conducted whole exome sequencing...
Comparative Study
Biological chemistry. 2016 Aug 1;397(8):791-801. DOI:10.1515/hsz-2015-0300 2016