Human 20S proteasome activity towards fluorogenic peptides of various chain lengths [0.03%]
人20S蛋白酶体对各种长度的荧光多肽底物的作用研究
Wioletta Rut,Marcin Drag
Wioletta Rut
The proteasome is a multicatalytic protease responsible for the degradation of misfolded proteins. We have synthesized fluorogenic substrates in which the peptide chain was systematically elongated from two to six amino acids and evaluated ...
Insights into K-Ras 4B regulation by post-translational lysine acetylation [0.03%]
论点：K-Ras 4B蛋白赖氨酸乙酰化后的调节机制见解
Philipp Knyphausen,Franziska Lang,Linda Baldus et al.
Philipp Knyphausen et al.
Ras is a molecular switch cycling between an active, GTP-bound and an inactive, GDP-bound state. Mutations in Ras, mostly affecting the off-switch, are found in many human tumours. Recently, it has been shown that K-Ras 4B is targeted by ly...
Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors [0.03%]
胰腺导管腺癌肿瘤中脯氨酰奥肽酶前体E高度丰富但活性较低
Anthony J O&#x;Donoghue,Sam L Ivry,Chaity Chaudhury et al.
Anthony J O&#x;Donoghue et al.
The cathepsin family of lysosomal proteases is increasingly being recognized for their altered expression in cancer and role in facilitating tumor progression. The aspartyl protease cathepsin E is overexpressed in several cancers and has be...
Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination [0.03%]
自噬介导的线粒体质量与数量控制：泛素化及去泛素化的调控作用机制初探
Tao Tan,Marcel Zimmermann,Andreas S Reichert
Tao Tan
Mitophagy is a selective autophagy pathway conserved in eukaryotes and plays an essential role in mitochondrial quality and quantity control. Mitochondrial fission and fusion cycles maintain a certain amount of healthy mitochondria and allo...
EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22 [0.03%]
EDA域含蛋白1通过miR-22影响胃癌的体内外生长并作为预后标志物
Min Yang,Nan Jiang,Qi-Wei Cao et al.
Min Yang et al.
Gastric cancer is the most common digestive malignant tumor worldwild. EDD1 was reported to be frequently amplified in several tumors and played an important role in the tumorigenesis process. However, the biological role and potential mech...
Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1 [0.03%]
髓系条件型敲除和转基因小鼠模型揭示了中性粒细胞存活因子Serpinb1的阈值效应
Sabrina S Burgener,Mathias Baumann,Paola Basilico et al.
Sabrina S Burgener et al.
Serpinb1 is an inhibitor of neutrophil granule serine proteases cathepsin G, proteinase-3 and elastase. One of its core physiological functions is to protect neutrophils from granule protease-mediated cell death. Mice lacking Serpinb1a (Sb1...
The potential of the Galleria mellonella innate immune system is maximized by the co-presentation of diverse antimicrobial peptides [0.03%]
多元抗菌肽的协同展示可使瓜尔利亚 Mellonella 免疫系统潜力最大化
Mohammad Reza Bolouri Moghaddam,Miray Tonk,Christine Schreiber et al.
Mohammad Reza Bolouri Moghaddam et al.
Antimicrobial peptides (AMPs) are ubiquitous components of the insect innate immune system. The model insect Galleria mellonella has at least 18 AMPs, some of which are still uncharacterized in terms of antimicrobial activity. To determine ...
Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state [0.03%]
三种与肌萎缩侧索硬化相关的新型profilin-1变异体的生物物理分析表明，它们的聚集倾向与其球状状态的结构特征之间存在相关性
Edoardo Del Poggetto,Ludovica Gori,Fabrizio Chiti
Edoardo Del Poggetto
Profilin-1 is a small protein involved in actin-mediated cytoskeleton rearrangement. Recently, mutations of profilin-1 have been associated with familial amyotrophic lateral sclerosis. It was previously reported that pathogenic mutations of...
The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria [0.03%]
Her2及其他PI3K/AKT途径致癌基因的线粒体功能及相关乳腺癌细胞代谢表型的作用机制研究
Katerina Rohlenova,Jiri Neuzil,Jakub Rohlena
Katerina Rohlenova
Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well as to cell death induction. Hyperactivation of pro-survival and pro-proliferative ...
Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy [0.03%]
NAD(P)H脱氢醌还原酶(NQO1*2)基因多态性与NQO1水平和糖尿病肾病发病风险的关联研究
Mohini Sharma,Mohit Mehndiratta,Stuti Gupta et al.
Mohini Sharma et al.
NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes reactions having a cyto-protective effect against redox cycling and oxidative stress. A single base polymorphism (C/T) at nucleotide 609 of the NQO1 gene impairs the stability and function o...