Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells [0.03%]
外泌体miR-375通过DNA甲基化调控KLK7基因表达抑制胰腺癌和宫颈癌细胞的侵袭和转移
Ilangovan Raju,Gur P Kaushal,Randy S Haun
Ilangovan Raju
Kallikrein-related peptidase 7 (KLK7) is a serine protease encoded within the kallikrein gene cluster located on human chromosome region 19q13.3-13.4. KLK7 is overexpressed in human pancreatic ductal adenocarcinomas (PDACs), but not in norm...
Hepatitis B virus surface protein-induced hPIAS1 transcription requires TAL1, E47, MYOG, NFI, and MAPK signal pathways [0.03%]
乙型肝炎病毒表面蛋白诱导hPIAS1转录需要TAL1、E47、MYOG、NFI和MAPK信号通路
Hongyan Wang,Di Wu,Xiaofeng Wang et al.
Hongyan Wang et al.
The protein inhibitor of activated STAT1 (PIAS1) plays important roles in regulating virus-induced chronic hepatitis, but the interaction between hepatitis B virus (HBV) and hPIAS1 is not clear. Our aim was to verify if HBV encoding protein...
Giovanna Leoni,Asma Nusrat
Giovanna Leoni
Epithelial barriers play an important role in regulating mucosal homeostasis. Upon injury, the epithelium and immune cells orchestrate repair mechanisms that re-establish homeostasis. This process is highly regulated by protein and lipid me...
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC [0.03%]
c-Myc转基因肝细胞癌小鼠模型和人类HCC中糖基磷脂酰肌醇锚定蛋白及糖基磷脂酰肌醇磷脂酶D的调节机制研究
Maria Stella Ritorto,Heidrun Rhode,Arndt Vogel et al.
Maria Stella Ritorto et al.
Recent research implicated glycosylphosphatidylinositol-anchored proteins (GPI-AP) and GPI-specific phospholipase D (GPI-PLD) in the pathogenesis of fatty liver disease and hepatocellular carcinoma (HCC). Given that c-Myc is frequently ampl...
Bhavin Shah,Andreas W Püschel
Bhavin Shah
Small GTPases are central regulators of many cellular processes. The highly conserved Rap GTPases perform essential functions in the mammalian nervous system during development and in mature neurons. During neocortical development, Rap1 is ...
Biological characteristics of renal cancer cells after CTP-mediated cancer suppressor gene NPRL2 protein treatment [0.03%]
CTP介导的抑癌基因NPRL2蛋白对肾癌细胞生物学特性的改变
Yang Zeng,Xiao-Bo Shi,Zheng-Yong Yuan et al.
Yang Zeng et al.
Nitrogen permease regulator like-2 (NPRL2) has been proved to be a useful suppressor gene in treating many cancers containing renal cancer based on experiments. Transgenic technology which transfect exogenous NPRL2 gene into cancer cell was...
MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer [0.03%]
微小核糖核酸-544通过下调Bcl6和Stat3抑制三阴性乳腺癌细胞的增殖和体内成瘤能力
Zhengzhi Zhu,Shengying Wang,Jinhai Zhu et al.
Zhengzhi Zhu et al.
Triple negative breast cancer lacking estrogen receptor (ER), progesterone receptor and Her2 account for account for the majority of the breast cancer deaths, due to the lack of specific gene targeted therapy. Our current study aimed to inv...
Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains [0.03%]
四跨膜蛋白8通过四跨膜蛋白富集微域与金屬基質蛋酶β相互作用
Frederike Schmidt,Miryam Müller,Johannes Prox et al.
Frederike Schmidt et al.
Meprin β is a dimeric type I transmembrane protein and acts as an ectodomain sheddase at the cell surface. It has been shown that meprin β cleaves the amyloid precursor protein (APP), thereby releasing neurotoxic amyloid β peptides and i...
Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains [0.03%]
四跨膜蛋白8是金属肽酶meprinβ在四跨膜蛋白富集微区内的相互作用分子
Frederike Schmidt,Miryam Müller,Johannes Prox et al.
Frederike Schmidt et al.
Meprin β is a dimeric type I transmembrane protein and acts as an ectodomain sheddase at the cell surface. It was shown that meprin β cleaves the amyloid precursor protein (APP), thereby releasing neurotoxic amyloid β peptides and implic...
Simone Fulda
Simone Fulda