Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A [0.03%]
维生素C通过组蛋白去甲基化酶JARID1A促进人诱导多能干细胞的多能性
Wassim Eid,Wafaa Abdel-Rehim
Wassim Eid
Somatic cells can be reprogramed into induced pluripotent stem (iPS) cells by defined factors, which provide a powerful basis for personalized stem-cell based therapies. However, cellular reprograming is an inefficient and metabolically dem...
Retraction Note to the article: "EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22" [0.03%]
撤回注意：论文“EDD1预测预后并通过miR-22在体外和体内调节胃癌生长”
Min Yang,Nan Jiang,Qi-Wei Cao et al.
Min Yang et al.
Retraction of Publication
Biological chemistry. 2016 Sep 1:/j/bchm.just-accepted/hsz-2016-0240/hsz-2016-0240.xml. DOI:10.1515/hsz-2016-0240 2016
Theresa Louise Boye,Jesper Nylandsted
Theresa Louise Boye
Disruption of the plasma membrane poses deadly threat to eukaryotic cells and survival requires a rapid membrane repair system. Recent evidence reveal various plasma membrane repair mechanisms, which are required for cells to cope with memb...
Hideaki Nagase
Hideaki Nagase
I was given the honor of delivering the 2015 Lifetime Membership Award lecture at the International Proteolysis Society's annual meeting held in Penang, Malaysia in October 2015. It gave me an opportunity to look back on how I started my re...
Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2',3,4,4'-tetramethoxychalcones α-Br-TMC and α-CF3-TMC [0.03%]
合成α-Br-TMC和α-CF3-TMC chalcone通过抑制白细胞介素-3和干扰素-α诱导的JAK/STAT信号传导发挥作用
Belinda Jobst,Julia Weigl,Carina Michl et al.
Belinda Jobst et al.
The JAK/STAT pathway is an essential mediator of cytokine signaling, often upregulated in human diseases and therefore recognized as a relevant therapeutic target. We previously identified the synthetic chalcone α-bromo-2',3,4,4'-tetrameth...
Thomas Grewal,Sundeep J Wason,Carlos Enrich et al.
Thomas Grewal et al.
Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca2+) - dependent manner. Studies with purified annexins, as well as overexpression and knockdown approaches identified multiple functions predominantly...
A computational analysis of the genetic and transcript diversity at the kallikrein locus [0.03%]
卡尔利因基因座的遗传和转录多样性计算分析
John Lai,Jiyuan An,Srilakshmi Srinivasan et al.
John Lai et al.
The kallikrein related peptidase gene family (KLKs) comprises 15 genes located between 19q13.3-13.4. KLKs have chymotrypsin and/or trypsin like activity, but the tissue/organ expression profile of each KLK varies considerably. Thus, the rol...
Fusion proteins of an enoate reductase and a Baeyer-Villiger monooxygenase facilitate the synthesis of chiral lactones [0.03%]
基于烯酸还原酶和Baeyer-Villiger单加氧酶融合蛋白的合成手性内酯的新方法研究进展
Christin Peters,Florian Rudroff,Marko D Mihovilovic et al.
Christin Peters et al.
Nature uses the advantages of fusion proteins for multi-step reactions to facilitate the metabolism in cells as the conversion of substrates through intermediates to the final product can take place more rapidly and with less side-product f...
Sebastian P Straub,Sebastian B Stiller,Nils Wiedemann et al.
Sebastian P Straub et al.
Mitochondria contain elaborate machineries for the import of precursor proteins from the cytosol. The translocase of the outer mitochondrial membrane (TOM) performs the initial import of precursor proteins and transfers the precursors to do...
Saioa R Elezgarai,Emiliano Biasini
Saioa R Elezgarai
A number of unexpected pathophysiological connections linking different neurodegenerative diseases have emerged over the past decade. An example is provided by prion and Alzheimer's diseases. Despite being distinct pathologies, these disord...