Ursula Rescher,Thomas Grewal
Ursula Rescher
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer [0.03%]
基质金属蛋白酶6(KLK6)和8(KLK8)在晚期浆液性卵巢癌中的临床意义研究
Nancy Ahmed,Julia Dorn,Rudolf Napieralski et al.
Nancy Ahmed et al.
Most members of the kallikrein-related peptidase family have been demonstrated to be dysregulated in ovarian cancer and modulate tumor growth, migration, invasion, and resistance to chemotherapy. In the present study, we assessed the mRNA e...
Comparison of the ability of mammalian eEF1A1 and its oncogenic variant eEF1A2 to interact with actin and calmodulin [0.03%]
哺乳动物eEF1A1与其致癌变体eEF1A2与肌动蛋白和钙调素相互作用能力的比较分析
Oleksandra Novosylna,Annette Doyle,Dmytro Vlasenko et al.
Oleksandra Novosylna et al.
The question as to why a protein exerts oncogenic properties is answered mainly by well-established ideas that these proteins interfere with cellular signaling pathways. However, the knowledge about structural and functional peculiarities o...
Comparative Study
Biological chemistry. 2017 Jan 1;398(1):113-124. DOI:10.1515/hsz-2016-0172 2017
Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: the ribotoxin anisoplin [0.03%]
来源于昆虫病原真菌绿僵菌的新毒素——核糖体inactivating protein类毒蛋白anisoplin的性质研究
Miriam Olombrada,Pilar Medina,Flor Budia et al.
Miriam Olombrada et al.
Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with e...
More than just innate affairs - on the role of annexins in adaptive immunity [0.03%]
不仅仅是先天性事务——关于annexin在适应性免疫中的作用
Heiko Weyd
Heiko Weyd
In more than 30 years of research annexins have been demonstrated to regulate immune responses. The prototype member of this family, annexin (Anx) A1, has been widely recognized as an anti-inflammatory mediator affecting migration and cellu...
Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein [0.03%]
耐热蛋白质金黄色葡萄球菌酰基载体蛋白(acpP)的结构分析及互作研究
Kathrin Volk,Sven D Breunig,Raphaela Rid et al.
Kathrin Volk et al.
Acyl-carrier-protein (acpP) is an essential protein in fatty acid biosynthesis of Staphylococcus aureus [Cronan, J.E. and Thomas, J. (2009). Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and ...
A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III [0.03%]
一种具有双酶活性的新型植物酶：非典型Nudix水解酶和二肽基肽酶III
Zrinka Karačić,Bojana Vukelić,Gabrielle H Ho et al.
Zrinka Karačić et al.
In a search for plant homologues of dipeptidyl peptidase III (DPP III) family, we found a predicted protein from the moss Physcomitrella patens (UniProt entry: A9TLP4), which shared 61% sequence identity with the Arabidopsis thaliana unchar...
Anticalins directed against vascular endothelial growth factor receptor 3 (VEGFR-3) with picomolar affinities show potential for medical therapy and in vivo imaging [0.03%]
针对血管内皮生长因子受体3（VEGFR-3）的抗抗加州鼠单克隆抗体治疗具有皮摩尔亲合力和体内成像潜力
Antonia Richter,Arne Skerra
Antonia Richter
Members of the vascular endothelial growth factor receptor (VEGFR) family play a central role in angiogenesis as well as lymphangiogenesis and are crucial for tumor growth and metastasis. In particular, VEGFR-3 expression is induced in endo...
The power, pitfalls and potential of the nanodisc system for NMR-based studies [0.03%]
用于基于NMR研究的纳米盘系统的潜能、风险和可能性
Aldino Viegas,Thibault Viennet,Manuel Etzkorn
Aldino Viegas
The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique ...
Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis [0.03%]
血管内皮细胞胞外分泌中的 annexin A2 和 A8 的作用及对血管稳态的调控作用
Volker Gerke
Volker Gerke
Blood vessel homeostasis is controlled by a variety of regulatory circuits that involve both the vessel-lining endothelial cells as well as the circulating blood cells and products thereof. One important feature is the control exerted by en...