Expression, regulation and function of intestinal drug transporters: an update [0.03%]
肠道药物转运体的表达、调节和功能：最新研究进展
Janett Müller,Markus Keiser,Marek Drozdzik et al.
Janett Müller et al.
Although oral drug administration is currently the favorable route of administration, intestinal drug absorption is challenged by several highly variable and poorly predictable processes such as gastrointestinal motility, intestinal drug so...
Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10 [0.03%]
锌离子抑制zymogen-like枯草杆菌肽酶相关蛋白酶10的结构基础
Mekdes Debela,Viktor Magdolen,Wolfram Bode et al.
Mekdes Debela et al.
Although kallikrein-related peptidase 10 (KLK10) is expressed in a variety of human tissues and body fluids, knowledge of its physiological functions is fragmentary. Similarly, the pathophysiology of KLK10 in cancer is not well understood. ...
Manuel Wagner,Katja Doehl,Lutz Schmitt
Manuel Wagner
ABC (ATP-binding cassette) transporters are ubiquitous integral membrane proteins catalyzing the active export or import of structurally and functionally unrelated compounds. In humans, these proteins are clinically and economically importa...
A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene [0.03%]
基于Spink5基因嵌合型失活的治疗纳特霍顿综合征可行的鼠标模型
Petr Kasparek,Zuzana Ileninova,Radka Haneckova et al.
Petr Kasparek et al.
Netherton syndrome (NS) is caused by mutations in the SPINK5 gene. Several Spink5-deficient mouse models were generated to understand the mechanisms of NS in vivo. However, Spink5-deficiency in mice is associated with postnatal lethality th...
Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis [0.03%]
相关激肽原酶6通过加剧自身免疫诱导的小鼠多发性硬化症病情恶化中的作用
Hyesook Yoon,Isobel A Scarisbrick
Hyesook Yoon
Kallikrein-related peptidase 6 (Klk6) is elevated in the serum of multiple sclerosis (MS) patients and is hypothesized to participate in inflammatory and neuropathogenic aspects of the disease. To test this hypothesis, we investigated the i...
Duncan J Campbell
Duncan J Campbell
The kallikrein kinin system has cardioprotective actions and mediates in part the cardioprotection produced by angiotensin converting enzyme inhibitors and angiotensin type 1 receptor blockers. Additional approaches to exploit the cardiopro...
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B [0.03%]
KLK14通过调节HGF/Met轴组分的表达和活性来抑制肝细胞癌体外实验证据
Janet C Reid,Nigel C Bennett,Carson R Stephens et al.
Janet C Reid et al.
Kallikrein-related peptidase (KLK) 14 is a serine protease linked to several pathologies including prostate cancer. We show that KLK14 has biphasic effects in vitro on activating and inhibiting components of the prostate cancer associated h...
Alessandra Fraternale,Serena Brundu,Mauro Magnani
Alessandra Fraternale
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment, which is important for several cellular functions. Altered intracellular...
E-beam crosslinked nanogels conjugated with monoclonal antibodies in targeting strategies [0.03%]
用于靶向策略的电子束交联纳米凝胶与单克隆抗体连接
Giorgia Adamo,Natascia Grimaldi,Maria Antonietta Sabatino et al.
Giorgia Adamo et al.
Poly(N-vinyl pyrrolidone)-based-nanogels (NGs), produced by e-beam irradiation, are conjugated with monoclonal antibodies (mAb) for active targeting purposes. The uptake of immuno-functionalized nanogels is tested in an endothelial cell lin...
Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications [0.03%]
细胞内外的α-突触核蛋白：功能和非功能影响
Denis Ottolini,Tito Calí,Ildikò Szabò et al.
Denis Ottolini et al.
Alpha-synuclein (α-syn) is an abundant neuronal protein whose physiological function, even if still not completely understood, has been consistently related to synaptic function and vesicle trafficking. A group of disorders known as synucl...