Susann Zilkenat,Iwan Grin,Samuel Wagner
Susann Zilkenat
Gaining knowledge of the structural makeup of protein complexes is critical to advance our understanding of their formation and functions. This task is particularly challenging for transmembrane protein complexes, and grows ever more imposi...
Pokemon decreases the transcriptional activity of RARα in the absence of ligand [0.03%]
在无配体存在的情况下，Pokemon可通过降低RARα转录活性发挥其抗肿瘤作用
Yutao Yang,Yueting Li,Fei Di et al.
Yutao Yang et al.
Pokemon is a transcriptional repressor that belongs to the POZ and Krüppel (POK) protein family. In this study, we investigated the potential interaction between Pokemon and retinoic acid receptor alpha (RARα) and determined the role of P...
Strong pH dependence of coupling efficiency of the Na+ - translocating NADH:quinone oxidoreductase (Na+-NQR) of Vibrio cholerae [0.03%]
Vibrio cholerae Na+-NQR偶联效率的强pH依赖性
Charlotte Toulouse,Björn Claussen,Valentin Muras et al.
Charlotte Toulouse et al.
The Na+-translocating NADH:quinone oxidoreductase (NQR) is the entry site for electrons into the respiratory chain of Vibrio cholerae, the causative agent of cholera disease. NQR couples the electron transfer from NADH to ubiquinone to the ...
Patrick Ernst,Andreas Plückthun
Patrick Ernst
The specific recognition of peptides, which we define to include unstructured regions or denatured forms of proteins, is an intrinsic part of a multitude of biochemical assays and procedures. Many cellular interactions are also based on thi...
Multifunctional biomaterial coatings: synthetic challenges and biological activity [0.03%]
多功能生物材料涂层：合成挑战与生物学活性
Mareen Pagel,Annette G Beck-Sickinger
Mareen Pagel
A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of vari...
Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria [0.03%]
病原菌及共生菌γ-谷氨酰胺转肽酶的酶学性质及小分子抑制剂的比较研究
Christian Bolz,Nina C Bach,Hannelore Meyer et al.
Christian Bolz et al.
Helicobacter pylori infects the stomach of 50% of the population worldwide, thus causing chronic gastritis. Although this infection can be cured by antibiotic treatment, therapeutic options are increasingly limited due to the development of...
Development of a screening system for inteins active in protein splicing based on intein insertion into the LacZα-peptide [0.03%]
基于intein插入LacZα肽的蛋白拼接活性intein筛选系统的建立与发展
Maximilian Neugebauer,Jana K Böcker,Julian C J Matern et al.
Maximilian Neugebauer et al.
Protein splicing by inteins has found diverse applications in biotechnology, protein chemistry and chemical biology. Inteins display a wide range of efficiencies and rates unpredictable from their amino acid sequences. Here, we identified p...
Kallikrein(K1)-kinin-kininase (ACE) and end-organ damage in ischemia and diabetes: therapeutic implications [0.03%]
缺血和糖尿病中的激肽释放酶(k1)-激肽-激肽酶(ace)系统与终末器官损伤：治疗学意义
Dorinne Desposito,Ludovic Waeckel,Louis Potier et al.
Dorinne Desposito et al.
Genetic and pharmacological studies, clinical and experimental, focused on kallikrein-K1, kinin receptors and ACE/kininase II suggest that kinin release in the settings of ischemia or diabetes reduces organ damage, especially in the heart a...
A role for the metalloprotease invadolysin in insulin signaling and adipogenesis [0.03%]
一种金属蛋白酶invadolysin在胰岛素信号传导和脂肪细胞生成中的作用
Ching-Wen Chang,Kanishk Abhinav,Francesca Di Cara et al.
Ching-Wen Chang et al.
Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell cycle and cell migration, linking to metabolism through a role in ...
Christine C Helms,Xiaohua Liu,Daniel B Kim-Shapiro
Christine C Helms
Nitrite was once thought to be inert in human physiology. However, research over the past few decades has established a link between nitrite and the production of nitric oxide (NO) that is potentiated under hypoxic and acidic conditions. Un...