Structural homology of mite profilins to plant profilins is not indicative of allergic cross-reactivity [0.03%]
螨profilin与植物profilin的结构同源性并不表明其具有交叉过敏反应性
Andrea O&#x;Malley,Sahana Sankaran,Avery Carriuolo et al.
Andrea O&#x;Malley et al.
Structural and allergenic characterization of mite profilins has not been previously pursued to a similar extent as plant profilins. Here, we describe structures of profilins originating from Tyrophagus putrescentiae (registered allergen Ty...
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy [0.03%]
基于诱导多能干细胞的心肌病病理表型特征识别的集成机器学习及多模态数据融合研究
Ruheen Wali,Hang Xu,Cleophas Cheruiyot et al.
Ruheen Wali et al.
Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to d...
18β-glycyrrhetinic acid alleviates radiation-induced skin injury by activating the Nrf2/HO-1 signaling pathway [0.03%]
甘草次酸通过激活Nrf2/HO-1信号通路缓解放射性皮炎
Zeng Wang,Ruiqing Chen,Junying Chen et al.
Zeng Wang et al.
Radiation-induced skin injury is a common side effect of radiotherapy, but there are few therapeutic drugs available for prevention or treatment. In this study, we demonstrate that 18β-Glycyrrhetinic acid (18β-GA), a bioactive component d...
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation [0.03%]
含载脂蛋白E的脂蛋白及其与LRP1的胞外相互作用影响LPS诱导的炎症反应
Shogo Akahane,Hiroto Matsuura,Takahiro Kaido et al.
Shogo Akahane et al.
The linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pa...
Study of two glycosyltransferases related to polysaccharide biosynthesis in Rhodococcus jostii RHA1 [0.03%]
关于Rhodococcus jostii RHA1中多糖生物合成相关的两种糖基转移酶的研究
Antonela Estefania Cereijo,María Victoria Ferretti,Alberto Alvaro Iglesias et al.
Antonela Estefania Cereijo et al.
The bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and ...
Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family [0.03%]
酵母Bxi1/Ybh3介导了酵母和哺乳动物细胞中的保守线粒体自噬和凋亡：Bcl-2家族的汇聚
Yuying Wang,Zhiyuan Hu,Maojun Jiang et al.
Yuying Wang et al.
The process of degrading unwanted or damaged mitochondria by autophagy, called mitophagy, is essential for mitochondrial quality control together with mitochondrial apoptosis. In mammalian cells, pan-Bcl-2 family members including conical B...
Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells [0.03%]
Chk1的抑制刺激了铂类药物和TRAIL结合在人体前列腺癌细胞中的细胞毒作用
Martin Krkoška,Kamil Paruch,Tereza Šošolíková et al.
Martin Krkoška et al.
Checkpoint kinase 1 (Chk1) plays an important role in regulation of the cell cycle, DNA damage response and cell death, and represents an attractive target in anticancer therapy. Small-molecule inhibitors of Chk1 have been intensively inves...
KCTD5 regulates Ikaros degradation induced by chemotherapeutic drug etoposide in hematological cells [0.03%]
KCTD5调节化学治疗药物依托泊苷诱导的血液细胞Ikaros降解
Lan Ma,Changqing Yin,Yi Zhang et al.
Lan Ma et al.
Therapy-related leukemia carries a poor prognosis, and leukemia after chemotherapy is a growing risk in clinic, whose mechanism is still not well understood. Ikaros transcription factor is an important regulator in hematopoietic cells devel...
Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate [0.03%]
Cathepsin X的缺乏改变了cathepsin L的处理和定位，并阻碍了核cathepsin L底物的裂解
Bangyan Xu,Bethany M Anderson,Simon J Mountford et al.
Bangyan Xu et al.
Proteases function within sophisticated networks. Altering the activity of one protease can have sweeping effects on other proteases, leading to changes in their activity, structure, specificity, localisation, stability, and expression. Usi...
Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1 [0.03%]
抗病毒和促转移蛋白IFITM1的构象变体的生化证据
Marta Nekulová,Marta Wyszkowska,Nela Friedlová et al.
Marta Nekulová et al.
Interferon induced transmembrane proteins (IFITMs) play a dual role in the restriction of RNA viruses and in cancer progression, yet the mechanism of their action remains unknown. Currently, there is no data about the basic biochemical feat...