Pathological and physiological roles of ADP-ribosylation: established functions and new insights [0.03%]
ADP核糖基化的病理和生理作用：已知功能与新见解
Karla L H Feijs-Žaja,Nonso J Ikenga,Roko Žaja
Karla L H Feijs-Žaja
The posttranslational modification of proteins with poly(ADP-ribose) was discovered in the sixties. Since then, we have learned that the enzymes involved, the so-called poly(ADP-ribosyl)polymerases (PARPs), are transferases which use cofact...
Insights in caveolae protein structure arrangements and their local lipid environment [0.03%]
凹膜蛋白结构排列及其局部脂质环境的见解
Esther Ocket,Claudia Matthaeus
Esther Ocket
Caveolae are 50-80 nm sized plasma membrane invaginations found in adipocytes, endothelial cells or fibroblasts. They are involved in endocytosis, lipid uptake and the regulation of the cellular lipid metabolism as well as sensing and adapt...
Development of an enabling platform biotechnology for the production of proteins [0.03%]
一种用于蛋白质生产的平台生物技术的发展
Isabel Aschenbrenner,Maximilian Böckler,Fabian Franke et al.
Isabel Aschenbrenner et al.
Protein-based drugs are a mainstay of modern medicine. In contrast to antibodies, most of these need highly individualized production processes which often limits their development. Here, we develop an immunoglobulin domain tag (i-Tag), whi...
Matthias J Feige
Matthias J Feige
Brennan McDonald,Mirko H H Schmidt
Brennan McDonald
The secreted factor Epidermal growth factor-like protein 7 (EGFL7) is involved in angiogenesis, vasculogenesis, as well as neurogenesis. Importantly, EGFL7 is also implicated in various pathological conditions, including tumor angiogenesis ...
Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies [0.03%]
超越CAR-T细胞：探索类似CAR的替代细胞来源疗法
Christina Angeliki Tsiverioti,Adrian Gottschlich,Marcel Trefny et al.
Christina Angeliki Tsiverioti et al.
Chimeric antigen receptor (CAR)-T cell therapy has led to remarkable clinical outcomes in the treatment of hematological malignancies. However, challenges remain, such as limited infiltration into solid tumors, inadequate persistence, syste...
Insights into caudate amphibian skin secretions with a focus on the chemistry and bioactivity of derived peptides [0.03%]
蛙类皮肤分泌物中的蝌蚪部分的化学和生物活性及其衍生肽的作用机制的研究进展
Lorena Kröner,Stefan Lötters,Marie-T Hopp
Lorena Kröner
Amphibians are well-known for their ability to produce and secrete a mixture of bioactive substances in specialized skin glands for the purpose of antibiotic self-protection and defense against predators. Some of these secretions contain va...
Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling [0.03%]
未配对半胱氨酸的插入有利于跨膜二聚化并诱导无配体依赖的细胞因子受体信号转导
Lynn Affrica Felicitas Baumgärtner,Julia Ettich,Helene Balles et al.
Lynn Affrica Felicitas Baumgärtner et al.
Naturally occurring gain-of-function (GOF) mutants have been identified in patients for a variety of cytokine receptors. Although this constitutive activation of cytokine receptors is strongly associated with malignant disorders, ligand-ind...
The complex regulation of Slo1 potassium channels from a structural perspective [0.03%]
从结构角度复杂调控Slo1钾通道
Tobias Raisch
Tobias Raisch
Fast and regulated potassium efflux by Slo1 channels is crucial in many tissues in animals including neurons, the kidney and smooth muscle. During the last decade, structures have revealed many details about the gating mechanism and regulat...
Advances in preclinical TCR characterization: leveraging cell avidity to identify functional TCRs [0.03%]
TCR表征的最新进展：利用细胞亲和力来鉴定功能性TCR
Andreas Carr,Laura M Mateyka,Sebastian J C Scheu et al.
Andreas Carr et al.
T-cell therapy has emerged as an effective approach for treating viral infections and cancers. However, a significant challenge is the selection of T-cell receptors (TCRs) that exhibit the desired functionality. Conventionally in vitro tech...