GPI-anchored serine proteases: essential roles in development, homeostasis, and disease [0.03%]
GPI锚定的丝氨酸蛋白酶：在发育、稳态和疾病中的重要作用
Joseph G Lundgren,Michael G Flynn,Karin List
Joseph G Lundgren
The glycosylphosphatidylinositol (GPI)-anchored serine proteases, prostasin and testisin, have essential roles in diverse physiological functions including development, reproduction, homeostasis and barrier function of epithelia, angiogenes...
Sarah Gabelmann,Michael Schroda
Sarah Gabelmann
The disruption of protein homeostasis leads to the increased un- and misfolding of proteins and the formation of toxic protein aggregates. Their accumulation triggers an unfolded protein response that is characterized by the transcriptional...
Johannes Ebding,Fiorella Mazzone,Stefan Kins et al.
Johannes Ebding et al.
Neurons are highly dependent on mitochondrial respiration for energy, rendering them vulnerable to oxidative stress. Reactive oxygen species (ROS), by-products of oxidative phosphorylation, can damage lipids, proteins, and DNA, potentially ...
Broadened substrate specificity of bacterial dipeptidyl-peptidase 7 enables release of half of all dipeptide combinations from peptide N-termini [0.03%]
细菌二肽基肽酶7的底物特异性扩展使其能够从多肽N末端释放一半以上的二肽组合
Kana Shirakura,Takayuki K Nemoto,Yuko Ohara Nemoto et al.
Kana Shirakura et al.
Dipeptide production mediated by dipeptidyl-peptidase (DPP)4, DPP5, DPP7, and DPP11 plays a crucial role in growth of Porphyromonas gingivalis, a periodontopathic asaccharolytic bacterium. Given the particular P1-position specificity of DPP...
Claudia Götz,Mathias Montenarh
Claudia Götz
In the early days of CK2 research, it was already published that the affinity of CK2 for its substrate casein was affected by insulin. Subsequent to the discovery of inhibitors of CK2 kinase activity, it was shown that CK2 has an influence ...
MitoStores: stress-induced aggregation of mitochondrial proteins [0.03%]
应激诱导的线粒体蛋白聚集物 Mitostore 的形成
Pragya Kaushik,Johannes M Herrmann,Katja G Hansen
Pragya Kaushik
Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into mitochondria. If the rate of protein synthesis exceeds the capacity of the mitochondrial import machinery, precursor proteins can transiently ...
Revival of the Escherichia coli heat shock response after two decades with a small Hsp in a critical but distinct act [0.03%]
大肠杆菌热激小分子伴侣在沉寂二十年后重新登场饰演重要而独特的角色
Tsukumi Miwa,Hideki Taguchi
Tsukumi Miwa
The heat stress response is an essential defense mechanism in all organisms. Heat shock proteins (Hsps) are produced in response to thermal stress, with their expression levels regulated by heat shock transcription factors. In Escherichia c...
Bioprospecting hydroxylated chalcones in in vitro model of ischemia-reoxygenation and probing NOX4 interactions via molecular docking [0.03%]
生物勘探羟基查尔酮在体外缺血再灌注模型中的作用及通过分子对接研究与NOX4的相互作用
Arif Ali,Igor Moreira de Almeida,Emanuel Paula Magalhães et al.
Arif Ali et al.
Ischemia/reperfusion injury (I/R) is a leading cause of acute kidney injury (AKI) in conditions like kidney transplants, cardiac surgeries, and nephrectomy, contributing to high global mortality and morbidity. This study aimed to analyze th...
Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates [0.03%]
KLK7自身消化的分析揭示了新的蛋白酶和细胞因子底物
Swapnil V Ghodge,Robert A Lazarus
Swapnil V Ghodge
Kallikrein-related peptidase 7 (KLK7) is one of 15 members of the tissue kallikrein family and is primarily expressed in the skin epidermis. The activity of KLK7 is tightly regulated by multiple stages of maturation and reversible inhibitio...
Carnosic acid prevents heat stress-induced oxidative damage by regulating heat-shock proteins and apoptotic proteins in mouse testis [0.03%]
肉桂酸通过调节热休克蛋白和凋亡蛋白预防热应激诱导的小鼠睾丸氧化损伤
Sirui Liu,Jiaxin Wu,Wanqing Liang et al.
Sirui Liu et al.
Heat stress impacts male reproduction in animal husbandry. Carnosic acid (CA), a potent antioxidant, mitigates oxidative stress and apoptosis. αB-crystallin, a small heat shock protein, regulates apoptosis and oxidative stress. This study ...