Apurva T Prabhakar,Iain M Morgan
Apurva T Prabhakar
Human papillomaviruses are causative agents in around 5 % of all cancers, and in a number of other human diseases. While prophylactic vaccines will alleviate the HPV disease burden on future generations, there are currently no therapeutic a...
Time- and dose-dependent effects of CIGB-300 on the proteome of lung squamous cell carcinoma [0.03%]
CIGB-300对肺癌鳞状细胞癌蛋白组的剂量和时间依赖性效应
Liudy García-Hernández,Lingfeng Dai,Arielis Rodríguez-Ulloa et al.
Liudy García-Hernández et al.
Proteome-wide scale in a dose - and time-depending setting is crucial to fully understand the pharmacological mechanism of anticancer drugs as well as identification of candidates for drug response biomarkers. Here, we investigated the effe...
Sonja Engler,Johannes Buchner
Sonja Engler
The molecular chaperone Hsp90 is the central element of a chaperone machinery in the cytosol of eukaryotic cells that is characterized by a large number of structurally and functionally different co-chaperones that influence the core chaper...
Nikolaos Charmpilas,Qiaochu Li,Thorsten Hoppe
Nikolaos Charmpilas
Mitochondria are central hubs of cellular metabolism and their dysfunction has been implicated in a variety of human pathologies and the onset of aging. To ensure proper mitochondrial function under misfolding stress, a retrograde mitochond...
Back to the basics: the molecular blueprint of plant heat stress transcription factors [0.03%]
回归基础：植物热应力转录因子的分子蓝图
Sotirios Fragkostefanakis,Enrico Schleiff,Klaus-Dieter Scharf
Sotirios Fragkostefanakis
Heat stress transcription factors (HSFs) play a pivotal role in regulating plant responses to heat and other environmental stresses, as well as developmental processes. HSFs possess conserved domains responsible for DNA binding, oligomeriza...
A CK2α' mutant indicating why CK2α and CK2α', the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2β [0.03%]
一个CK2α'突变体表明了为什么CK2α和CK2α'(案CK2催化亚基的同工异形体)在与CK2β结合时表现出不同的亲和力
Christian Werner,Sophia Eimermacher,Hugo Harasimowicz et al.
Christian Werner et al.
Protein kinase CK2 (casein kinase 2) mainly exists as heterotetrameric holoenzyme with two catalytic subunits (CK2α or CK2α') bound to a homodimer of non-catalytic subunits (CK2β). With CSNK2A1 and CSNK2A2, the human genome contains two ...
Prince Saforo Amponsah,Zuzana Storchová
Prince Saforo Amponsah
Aneuploidy refers to chromosome number abnormality that is not an exact multiple of the haploid chromosome set. Aneuploidy has largely negative consequences in cells and organisms, manifested as so-called aneuploidy-associated stresses. A m...
The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes [0.03%]
核糖体上的调控中心——新生多肽相关复合物(NAC)
Laurenz Rabl,Elke Deuerling
Laurenz Rabl
The correct synthesis of new proteins is essential for maintaining a functional proteome and cell viability. This process is tightly regulated, with ribosomes and associated protein biogenesis factors ensuring proper protein production, mod...
Joshua Jackson,Thomas Becker
Joshua Jackson
Mitochondrial functions and biogenesis depend on the import of more than 1,000 proteins which are synthesized as precursor proteins on cytosolic ribosomes. Mitochondrial protein translocases sort the precursor proteins into the mitochondria...
Exploring the biological potential of the brominated indenoindole MC11 and its interaction with protein kinase CK2 [0.03%]
溴化吲哚茚MC11的生物潜力探索及其与蛋白激酶CK2的相互作用
Christelle Marminon,Christian Werner,Alexander Gast et al.
Christelle Marminon et al.
Protein kinase CK2 is a promising therapeutic target, especially in oncology. Over the years, various inhibitors have been developed, with polyhalogenated scaffolds emerging as a particularly effective class. Halogens like bromine and chlor...