Conserved function, divergent evolution: mitochondrial outer membrane insertases across eukaryotes [0.03%]
保守的功能，分歧的进化：真核生物线粒体外膜插入酶
Anna Roza Dimogkioka,Doron Rapaport
Anna Roza Dimogkioka
Mitochondrial function relies heavily on the proper targeting and insertion of nuclear-encoded proteins into the outer mitochondrial membrane (OMM), a process mediated by specialised biogenesis factors known as insertases. These insertases ...
Rapid method for evaluation of CK2 enzymatic activity and CK2α/CK2β-interaction in Escherichia coli cell lysates [0.03%]
一种快速评估大肠杆菌裂解物中CK2酶活性和CK2α/CK2β相互作用的方法
Alexander Gast,Sebastian Schreiber,Joachim Jose
Alexander Gast
This study introduces a novel, rapid assay to measure CK2α activity in Escherichia coli cell lysates. By fusing CK2α with the fluorescent protein mScarlet it was possible to quantify CK2α concentration directly in lysates. We used the do...
Diversification of glutathione transferases in plants and their role in oxidative stress defense [0.03%]
植物谷胱甘肽转移酶的多样化及其在氧化应激防御中的作用
José M Ugalde,Manjeera Nath,Stephan Wagner et al.
José M Ugalde et al.
Plant exposure to unfavourable environmental conditions causes stress and reduces productivity. A common consequence of stress responses, are increased levels of reactive oxygen species (ROS), which if not controlled, could eventually lead ...
Johannes Buchner,Johannes M Herrmann
Johannes Buchner
Editorial
Biological chemistry. 2025 Jul 7. DOI:10.1515/hsz-2025-0168 2025
Felix Jung,David Zimmer,Timo Mühlhaus
Felix Jung
Stress responses in biological systems arise from complex, dynamic interactions among genes, proteins, and metabolites. A thorough understanding of these responses requires examining not only changes in individual molecular components but a...
Karsten Niefind,Claudia Götz,Joachim Jose
Karsten Niefind
Editorial
Biological chemistry. 2025 Jun 3. DOI:10.1515/hsz-2025-0147 2025
Triple SELEX approach for the selection of a highly specific RNA aptamer binding homoeriodictyol [0.03%]
用于选择高特异性的结合homoeriodictyol的RNA适配体的三重SELEX方法
Janis Hoetzel,Cristina Bofill-Bosch,Andres W Martinez et al.
Janis Hoetzel et al.
The application of synthetic riboswitches or aptamer-based biosensors for the monitoring of engineered metabolic pathways greatly depends on a high degree of target molecule specificity. Since metabolic pathways include close derivatives th...
The mitochondrial intermembrane space - a permanently proteostasis-challenged compartment [0.03%]
线粒体膜间空间——一个永久蛋白质稳态挑战区域
Matthias Weith,Konstantin Weiss,Dylan Stobbe et al.
Matthias Weith et al.
The mitochondrial intermembrane space (IMS) houses proteins essential for redox regulation, protein import, signaling, and energy metabolism. Protein import into the IMS is mediated by dedicated pathways, including the disulfide relay pathw...
TBK1 alleviates triptolide-induced nephrotoxic injury by up-regulating mitophagy in HK2 cells [0.03%]
TBK1通过上调HK2细胞线粒体自噬减轻三氧化二麟所致肾毒性损伤
Xinxin Lu,Qionghui Huang,Zhaohui He et al.
Xinxin Lu et al.
Tripterygium wilfordii has been used for a long time to treat autoimmune diseases. Its toxic side effects limit its clinical application. Mitophagy plays a protective role in various diseases. TANK-binding kinase 1 (TBK1) is a mitophagy-pro...
Pathogenic missense variants of CSNK2B associated with Poirier-Bienvenu neurodevelopmental disorder impact differently on CK2 holoenzyme formation [0.03%]
与Poirier-Bienvenu神经发育障碍相关的CSNK2B致病性错义变异对CK2全酶形成的影响不同
Hanna Kavaliova,Barbara Lecis,Demetra Ballardin et al.
Hanna Kavaliova et al.
Poirier-Bienvenu neurodevelopmental syndrome is a neurodevelopmental disorder associated with de novo variants of the CSNK2B gene, characterized by intellectual disability, developmental delay, frequent seizures and more. While the majority...