Inhibition of Aβ(40) peptide aggregation by Milk-derived Amyloid-like Protein Aggregates (MAPA) [0.03%]
乳源淀粉样蛋白类似物寡聚体抑制Aβ(40)肽聚集作用机制研究
Shweta Malik,Indranil De,Abhishek Singh Yadav et al.
Shweta Malik et al.
Recent studies have identified Aβ peptides in human gut epithelial cells, along with several amyloid-forming proteins and peptides in the gut lumen. These findings suggest that Aβ or other amyloid-like molecules originating from the gut m...
Albrecht Kossel and the nucleobases - a review of his life and work [0.03%]
阿尔伯特·科塞尔与核苷酸碱基——其生平及贡献综述
Edith Framm,Joachim Framm
Edith Framm
Albrecht Kossel (1853-1927) is associated with the discovery of the nucleobases adenine, guanine, thymine and cytosine, whose sequence in DNA forms genetic information. In 1910, he was awarded the Nobel Prize for his work, which was foundat...
Endocytic scaffolds at the crossroads of Alzheimer's disease and neuronal aging [0.03%]
内吞支架在阿尔茨海默病和神经元衰老的交叉路口
Jasmeet Kaur Shergill,Domenico Azarnia Tehran
Jasmeet Kaur Shergill
More than a century after Alois Alzheimer's neuropathological description, the mechanisms driving Alzheimer's disease (AD) remain only partially understood, and the failure of most clinical trials underscores the need to identify and target...
Alexandra Hilse,Tanja Maritzen
Alexandra Hilse
Intersectins with their numerous protein interaction domains serve as versatile scaffolds for a range of membrane-associated processes. While being originally characterized as endocytic proteins, their functions clearly extend beyond the sc...
Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra [0.03%]
基于径向频谱计算的人类心肌细胞肌小节分析
Michael Habeck,Hafiza Nosheen Saleem,Daria Plota et al.
Michael Habeck et al.
In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess the functional properties of sarcomeres at the nanosc...
Getting to the right place at the right time - membrane trafficking and maturation in the endolysosomal system [0.03%]
时空管控：内溶酶体系统膜运输与成熟机制研究进展
Alexander Stockhammer,Christian Ungermann
Alexander Stockhammer
The endolysosomal system connects Golgi and plasma membrane to the degradative pathway towards the lysosome and therefore presents a crossroads for endocytic recycling, secretory transport and degradation. This complexity makes protein sort...
Mechanistic insights into Ras-catalyzed GTP hydrolysis: conformational dynamics, catalytic mechanisms, and emerging therapeutic strategies [0.03%]
Ras催化的GTP水解的机理见解：构象动力学、催化机制和新兴治疗策略
Carsten Kötting,Till Rudack,Klaus Gerwert
Carsten Kötting
Ras is a key regulator of signal transduction in cells. Ras malfunction is associated with a huge variety of oncological diseases. It is turned off by hydrolysis of bound GTP, which is accelerated by GTPase-activating proteins (GAPs). This ...
There and back again: a cell biologist's journey from organelles to molecules [0.03%]
从细胞器到分子：一个细胞生物学家的旅程
Emma J Fenech,Yury S Bykov
Emma J Fenech
Eukaryotic life is defined by the presence of organelles. Organelles, in turn, were classically defined as specialized membrane-bound compartments composed of a unique set of macromolecules which support specific functions. Over the last fe...
Jack of all trades - the lipid droplet organization (LDO) proteins are multifunctional organelle surface receptors [0.03%]
多功能的“万事通”——脂滴组织(LDO)蛋白是多种多样的细胞器表面受体家族成员
Beatriz Leite,Maria Bohnert
Beatriz Leite
The literature on the lipid droplet organization (LDO) proteins Ldo16 and Ldo45 reads like a guided tour through the lipid droplet life cycle. Both yeast Ldo16/45 and their metazoan counterparts, the LDAF1/promethin proteins, were originall...
Tslil Ast
Tslil Ast
The diverse, and sometimes opposing, roles of mitochondria require sophisticated organizational and regulatory strategies. This review examines emerging evidence that mitochondria can solve this challenge through functional specialization -...