The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression [0.03%]
DEAD盒RNA解旋酶Dbp5是连接基因表达多个步骤的关键蛋白质
Luisa Querl,Heike Krebber
Luisa Querl
Cell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the ...
The human long non-coding RNA LINC00941 and its modes of action in health and disease [0.03%]
人类长链非编码RNA LINC00941及其在健康和疾病中的作用机制
Eva Morgenstern,Markus Kretz
Eva Morgenstern
Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true ...
Translation termination in human mitochondria - substrate specificity of mitochondrial release factors [0.03%]
人类线粒体中翻译终止-释放因子的底物特异性
Franziska Nadler,Ricarda Richter-Dennerlein
Franziska Nadler
Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conse...
Sarah Janice Hörner,Nathalie Couturier,Mathias Hafner et al.
Sarah Janice Hörner et al.
Neuromuscular cell culture models are used to investigate synapse formation and function, as well as mechanisms of de-and regeneration in neuromuscular diseases. Recent developments including 3D culture technique and hiPSC technology have p...
Two are not enough: synthetic strategies and applications of unnatural base pairs [0.03%]
不够用的两种碱基：人工碱基对的合成策略及应用
Robert Dörrenhaus,Philip K Wagner,Stephanie Kath-Schorr
Robert Dörrenhaus
Nucleic acid chemistry is a rapidly evolving field, and the need for novel nucleotide modifications and artificial nucleotide building blocks for diagnostic and therapeutic use, material science or for studying cellular processes continues ...
Structure and phase separation of the C-terminal domain of RNA polymerase II [0.03%]
RNA聚合酶II的C端结构与相分离
Irina P Lushpinskaia,David Flores-Solis,Markus Zweckstetter
Irina P Lushpinskaia
The repetitive heptads in the C-terminal domain (CTD) of RPB1, the largest subunit of RNA Polymerase II (Pol II), play a critical role in the regulation of Pol II-based transcription. Recent findings on the structure of the CTD in the pre-i...
Nikolaos Famelis,Sebastian Geibel,Daan van Tol
Nikolaos Famelis
Mycobacteria, such as the pathogen M. tuberculosis, utilize up to five paralogous type VII secretion systems to transport proteins across their cell envelope. Since these proteins associate in pairs that depend on each other for transport t...
Molecular simulations of DEAH-box helicases reveal control of domain flexibility by ligands: RNA, ATP, ADP, and G-patch proteins [0.03%]
分子模拟揭示DEAH盒解旋酶的结构域灵活性受配体调控：RNA、ATP、ADP和G-补丁蛋白的影响
Robert A Becker,Jochen S Hub
Robert A Becker
DEAH-box helicases use the energy from ATP hydrolysis to translocate along RNA strands. They are composed of tandem RecA-like domains and a C-terminal domain connected by flexible linkers, and the activity of several DEAH-box helicases is r...
Thomas Dittmar,Mareike Sieler,Ralf Hass
Thomas Dittmar
Cancer cell fusion represents a rare event. However, the surviving cancer hybrid cells after a post-hybrid selection process (PHSP) can overgrow other cancer cells by exhibiting a proliferation advantage and/or expression of cancer stem-lik...
Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics [0.03%]
点亮大脑——基因编码单色荧光生物传感器解析神经递质动态机制
Martin Kubitschke,Olivia A Masseck
Martin Kubitschke
Understanding how neuronal networks generate complex behavior is one of the major goals of Neuroscience. Neurotransmitter and Neuromodulators are crucial for information flow between neurons and understanding their dynamics is the key to un...