The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs [0.03%]
来自Pyrococcus furiosus的古细菌Lsm蛋白与富含poly(U)的目标RNA转录后结合
Robert Reichelt,Tamara Rothmeier,Felix Grünberger et al.
Robert Reichelt et al.
Posttranscriptional processes in Bacteria include the association of small regulatory RNAs (sRNA) with a target mRNA. The sRNA/mRNA annealing process is often mediated by an RNA chaperone called Hfq. The functional role of bacterial and euk...
Julianne Beirute-Herrera,Beatriz López-Amo Calvo,Frank Edenhofer et al.
Julianne Beirute-Herrera et al.
Advances of in vitro culture models have allowed unprecedented insights into human neurobiology. At the same time genetic screening has matured into a robust and accessible experimental strategy allowing for the simultaneous study of many g...
N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4 [0.03%]
N6-甲基腺苷诱导的METTL1通过CDK4促进肿瘤增殖
Chunyan Zhang,Yuanbo Cui
Chunyan Zhang
N6-methyladenosine (m6A) and N7-methylguanosine (m7G) modification of RNA represent two major intracellular post-transcriptional regulation modes of gene expression. However, the crosstalk of these two epigenetic modifications in tumorigene...
The Zika virus infection remodels the expression of the synaptotagmin-9 secretory protein [0.03%]
寨卡病毒感染重塑神经细胞分泌蛋白synaptotagmin-9的表达分布
Santiago Leiva,Alejo Cantoia,Cintia Fabbri et al.
Santiago Leiva et al.
The exact mechanisms involved in flaviviruses virions' release and the specific secretion of viral proteins, such as the Non Structural protein-1 (NS1), are still unclear. While these processes might involve vesicular transport to the cell ...
Cytosolic RGG RNA-binding proteins are temperature sensitive flowering time regulators in Arabidopsis [0.03%]
拟南芥细胞质RGG型RNA结合蛋白是开花时间的温度敏感性调节因子
Andrea Bleckmann,Nicole Spitzlberger,Philipp Denninger et al.
Andrea Bleckmann et al.
mRNA translation is tightly regulated by various classes of RNA-binding proteins (RBPs) during development and in response to changing environmental conditions. In this study, we characterize the arginine-glycine-glycine (RGG) motif contain...
Microtubules as a signal hub for axon growth in response to mechanical force [0.03%]
微管作为响应机械力的轴突生长信号中心
Alessandro Falconieri,Allegra Coppini,Vittoria Raffa
Alessandro Falconieri
Microtubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form p...
Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation [0.03%]
钙通道CaV2.1突变体在兴奋性突触前末梢的纳米尺度分布及其对突触传递的影响
Lorenzo A Cingolani,Agnes Thalhammer,Fanny Jaudon et al.
Lorenzo A Cingolani et al.
The distance between CaV2.1 voltage-gated Ca2+ channels and the Ca2+ sensor responsible for vesicle release at presynaptic terminals is critical for determining synaptic strength. Yet, the molecular mechanisms responsible for a loose coupli...
Alexander Hautke,Simon Ebbinghaus
Alexander Hautke
ATP is an important small molecule that appears at outstandingly high concentration within the cellular medium. Apart from its use as a source of energy and a metabolite, there is increasing evidence for important functions as a cosolute fo...
Rolf Heumann
Rolf Heumann
Optogenetics 2.0: challenges and solutions towards a quantitative probing of neural circuits [0.03%]
光遗传学2.0：向神经环路量化探测挑战与对策
Saleh Altahini,Isabelle Arnoux,Albrecht Stroh
Saleh Altahini
To exploit the full potential of optogenetics, we need to titrate and tailor optogenetic methods to emulate naturalistic circuit function. For that, the following prerequisites need to be met: first, we need to target opsin expression not o...