Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer [0.03%]
猫淋巴细胞抗原受体酪氨酸抑制分子1-like 1通过调节树突状细胞功能促进结核病中的细胞免疫反应
Marija Grozdanić,Barbara Sobotič,Monika Biasizzo et al.
Marija Grozdanić et al.
Proteolytic activity in the tumour microenvironment is an important factor in cancer development since it can also affect intracellular signalling pathways via positive feedback loops that result in either increased tumour growth or resista...
Features of yeast RNA polymerase I with special consideration of the lobe binding subunits [0.03%]
富含亮氨酸的臂部结合亚基的RNA聚合酶I的特征分析
Katrin Schwank,Catharina Schmid,Tobias Fremter et al.
Katrin Schwank et al.
Ribosomal RNAs (rRNAs) are structural components of ribosomes and represent the most abundant cellular RNA fraction. In the yeast Saccharomyces cerevisiae, they account for more than 60 % of the RNA content in a growing cell. The major amou...
Lukasz Piszczek,Joanna Kaczanowska,Wulf Haubensak
Lukasz Piszczek
Retracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid ...
The good or the bad: an overview of autoantibodies in traumatic spinal cord injury [0.03%]
利大于弊还是弊大于利？脊髓损伤中自身抗体的概述
Annika Guntermann,Katrin Marcus,Caroline May
Annika Guntermann
Infections remain the most common cause of death after traumatic spinal cord injury, likely due to a developing immune deficiency syndrome. This, together with a somewhat contradictory development of autoimmunity in many patients, are two m...
Highlight: how to synthesize, assemble and regulate ribonucleoprotein-complexes [0.03%]
聚焦：如何合成、组装和调控核糖核酸蛋白复合体
Herbert Tschochner
Herbert Tschochner
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice [0.03%]
HMGB1-RAGE轴线通过调节糖尿病小鼠心肌细胞自噬和凋亡参与心肌缺血再灌注损伤
De-Wei He,De-Zhao Liu,Xiao-Zhi Luo et al.
De-Wei He et al.
Patients with acute myocardial infarction complicated with diabetes are more likely to develop myocardial ischemia/reperfusion (I/R) injury (MI/RI) during reperfusion therapy. Both HMGB1 and RAGE play important roles in MI/RI. However, the ...
Liping Liu,Jakob Trendel,Guojing Jiang et al.
Liping Liu et al.
RNA binding proteins (RBPs) have multiple and essential roles in transcriptional and posttranscriptional regulation of gene expression in all living organisms. Their biochemical identification in the proteome of a given cell or tissue requi...
Simone Larivera,Julia Neumeier,Gunter Meister
Simone Larivera
MicroRNA (miRNA)-guided gene silencing is a key regulatory process in various organisms and linked to many human diseases. MiRNAs are processed from precursor molecules and associate with Argonaute proteins to repress the expression of comp...
Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation [0.03%]
硝基油酸的抗癌作用具有细胞类型特异性及其与γ射线联合治疗的效果
Tomas Perecko,Jana Pereckova,Zuzana Hoferova et al.
Tomas Perecko et al.
Nitro-fatty acids (NFAs) are endogenous lipid mediators capable of post-translational modifications of selected regulatory proteins. Here, we investigated the anti-cancerous effects of nitro-oleic acid (NO2OA) and its combination with gamma...
A structural biology view on the enzymes involved in eukaryotic mRNA turnover [0.03%]
从结构生物学角度探析真核mRNA周转相关酶的特征
Christina Krempl,Daniela Lazzaretti,Remco Sprangers
Christina Krempl
The cellular environment contains numerous ribonucleases that are dedicated to process mRNA transcripts that have been targeted for degradation. Here, we review the three dimensional structures of the ribonuclease complexes (Pan2-Pan3, Ccr4...