Human dipeptidyl peptidase III regulates G-protein coupled receptor-dependent Ca2+ concentration in human embryonic kidney 293T cells [0.03%]
人二肽基肽酶III调节人在胚胎肾293T细胞中G蛋白偶联受体依赖型钙离子浓度
Subhash C Prajapati,Ratnakar Singh,Shyam S Chauhan
Subhash C Prajapati
The precise biological function of human dipeptidyl peptidase III (hDPP III) is poorly understood. Using luciferase reporter constructs responsive to change in Ca2+ and/or cAMP and Fura 2-AM fluorometric assay, we show a significant decreas...
Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum [0.03%]
内质网上的PERK协调应激、钙离子及免疫信号通路之间的联系
Alexander R van Vliet,Abhishek D Garg,Patrizia Agostinis
Alexander R van Vliet
The endoplasmic reticulum (ER) is the main coordinator of intracellular Ca2+ signaling, protein synthesis, and folding. The ER is also implicated in the formation of contact sites with other organelles and structures, including mitochondria...
Role of reverse transendothelial migration of neutrophils in inflammation [0.03%]
中性粒细胞反向迁移在炎症中的作用研究
Yohei Hirano,Monowar Aziz,Ping Wang
Yohei Hirano
Transmigration of neutrophils through vascular endothelial walls into the inflamed tissues is a critical defense mechanism of innate immune system against infection and injury caused by sepsis, trauma, ischemia-reperfusion, and other acute ...
Clinical evaluation of microRNA-145 expression in renal cell carcinoma: a promising molecular marker for discriminating and staging the clear cell histological subtype [0.03%]
肾细胞癌中microRNA-145表达的临床评估：鉴别和分期透明细胞组织学亚型的 promising 分子标记物
Emmanuel I Papadopoulos,Constantina Petraki,Alkiviadis Gregorakis et al.
Emmanuel I Papadopoulos et al.
The vast majority of malignancies detected in renal parenchyma are diagnosed as renal cell carcinoma (RCC), whose subtype discrimination and determination of prognosis may contribute to the selection of the adequate therapy. Recently, a new...
Expression of MIF and CD74 in leukemic cell lines: correlation to DR expression destiny [0.03%]
细胞系中MIF和CD74的表达及其与DR分化的相关性研究
Mirella Georgouli,Lina Papadimitriou,Maria Glymenaki et al.
Mirella Georgouli et al.
Invariant chain (Ii) or CD74 is a non-polymorphic glycoprotein, which apart from its role as a chaperone dedicated to MHCII molecules, is known to be a high-affinity receptor for macrophage migration inhibitory factor (MIF). The present stu...
Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis [0.03%]
补体蛋白和微胶质细胞在双相情感障碍中的反应：一个神经炎症假说
Yahaira M Naaldijk,Maria C Bittencourt,Ulrich Sack et al.
Yahaira M Naaldijk et al.
Bipolar disorder (BD) is a severe psychiatric disorder that affects up to 15% of the worldwide population. Characterized by switches in mood between mania and depression, its etiology is still unknown and efforts have been made to elucidate...
Contrasting effects of cardiac glycosides on cisplatin- and etoposide-induced cell death [0.03%]
黄酮类化合物对顺铂和依托泊苷致细胞死亡的对比效应研究
Andrey V Kulikov,Ekaterina A Slobodkina,Andrey V Alekseev et al.
Andrey V Kulikov et al.
Cardiac glycosides (CGs) or cardiotonic steroids, which constitute a group of naturally occurring compounds with a steroid-like structure, can act on Na+/K+-ATPase as a receptor and activate intracellular signaling messengers leading to a v...
Mingsheng Cai,Jiang Si,Xiaowei Li et al.
Mingsheng Cai et al.
As an important protein, UL31 has been demonstrated to play multiple roles in herpes simplex virus 1 (HSV-1) replication. Previous studies showed that UL31 predominantly locates in the nucleus in chemical fixed cells and live cells, however...
Julie Laval,Anjali Ralhan,Dominik Hartl
Julie Laval
Cystic fibrosis (CF) lung disease is characterized by chronic infection and inflammation. Among inflammatory cells, neutrophils represent the major cell population accumulating in the airways of CF patients. While neutrophils provide the fi...
Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton [0.03%]
两种人肝源性生长因子的同工型与细胞骨架成分相互作用
Jessica Nüße,Ursula Mirastschijski,Mario Waespy et al.
Jessica Nüße et al.
Hepatoma-derived growth factor (HDGF) is involved in diverse, apparently unrelated processes, such as cell proliferation, apoptosis, DNA-repair, transcriptional control, ribosome biogenesis and cell migration. Most of the interactions of HD...