Electron donating and withdrawing groups affect the antioxidant activity of 4'-aminochalcones on gentamicin-induced kidney cell injury [0.03%]
Igor Moreira de Almeida,Akenaton Onassis Cardoso Viana Gomes,Arif Ali et al.
Igor Moreira de Almeida et al.
Gentamicin (GM)-induced nephrotoxicity is closely linked to oxidative stress, with few therapeutic alternatives available. Chalcones are structurally versatile compounds with reported antioxidant properties, making them attractive candidate...
Nils Rademacher,Poornima Anantha Subramanian,Sarah A Shoichet
Nils Rademacher
CNKSR proteins are multidomain scaffold proteins that coordinate protein complex formation and regulate intracellular signaling via diverse protein-protein interactions. Here, we focus on CNKSR2 (also known as CNK2 or MAGUIN), which is enco...
Luna Van Nimmen,Hanne Peeters,Shehab Ismail
Luna Van Nimmen
Lipid-modified membrane-associated proteins can bind reversibly to cellular membranes, and their steady-state localization reflects a balance between membrane-bound and cytosolic pools. For many small GTPases of the Rho and Rab families, th...
Miriam Kutsch,Christian Herrmann
Miriam Kutsch
Guanylate-binding proteins (GBPs) are interferon-inducible large GTPases that play a central role in cell-autonomous immunity against intracellular bacterial pathogens. A defining feature of GBPs is their ability to translate GTP binding an...
Mercedes Fissore-O&#x;Leary,Mark Philips
Mercedes Fissore-O&#x;Leary
RAS proteins control signals required for cell growth and survival and, when constitutively activated by mutation, can drive oncogenesis. RAS proteins are primarily regulated by their GTP or GDP binding state, which is controlled by guanine...
Roger S Goody,Matthias P Müller
Roger S Goody
Editorial
Biological chemistry. 2026 Apr 17. DOI:10.1515/hsz-2026-0132 2026
GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition [0.03%]
泛RAS TCI达拉索那西布模拟活性与K-RAS Switch-II袋抑制协同作用
Patrick Pfaff,Kevan M Shokat
Patrick Pfaff
Tricomplex inhibitors (TCIs) are a novel class of direct Ras inhibitors that target the GTP-bound Ras(on) state through recruitment of Cyclophilin A. Daraxonrasib (RMC-6236) is a pan-Ras TCI that was recently shown to restore GTPase activit...
Adherens junctions balance stability and motility: from cell morphogenesis to neural tissue patterning [0.03%]
粘附连接平衡稳定性和运动性：从细胞形态发生到神经组织模式化
Joachim Fuchs,Kawtar Cherkaoui,P Robin Hiesinger
Joachim Fuchs
Adherens junctions are cellular contact sites that organize epithelial tissues and play well-characterized roles in the coordination of cell collectives. Intercellular contacts are mediated by cadherin- or nectin-based adhesion and intracel...
The heart of the matter: a personal view of Fred Wittinghofer's contributions to RAS biology and drug design [0.03%]
一腔赤诚：弗雷德·威廷霍弗在RAS生物学及成药设计方面的贡献侧记
Frank McCormick
Frank McCormick
Alfred Wittinghofer and his group of structural biologists and biochemists laid the groundwork for developing drugs that target RAS, from the first structure of a RAS protein in its active state, through to a deep understanding of RAS funct...
Development of kallikrein-related peptidase 7 (KLK7) inhibitors and use in a species-adapted model for ovarian cancer [0.03%]
KLK7抑制剂的开发及其在卵巢癌种属适应模型中的应用研究
Torsten Steinmetzer,Laury S Mesa-Rangel,Sadaf Janghorban et al.
Torsten Steinmetzer et al.
The serine protease KLK7 contributes to several skin disorders and tumorigenesis, making it an attractive drug target. Owing to structural similarities in the S1 binding pocket between human KLK7 and certain trypsin-like serine proteases ha...