Clinical impact of primary and secondary KIT mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors [0.03%]
原发和继发KIT基因突变对胃肠间质瘤分子靶向治疗疗效的影响分析
Kota Kawabata,Tsuyoshi Takahashi,Toshirou Nishida et al.
Kota Kawabata et al.
Background: Gastrointestinal stromal tumors (GISTs) are commonly driven by primary mutations in KIT or PDGFRA. Imatinib is the first-line therapy for GISTs. However, secondary mutations frequently emerge during imatinib t...
Assessing efficacy of anti-glypican-1 antibody-drug conjugate as potential therapeutic approach for gastric cancer [0.03%]
评估抗glypican-1抗体药物偶联物作为治疗胃癌潜在方法的疗效
Yuji Suzuki,Satoshi Serada,Masashi Yamashita et al.
Yuji Suzuki et al.
Background: Despite significant advancements in cancer treatment, gastric cancer (GC) continues to have a high incidence and mortality rate. Antibody-drug conjugates (ADCs) are emerging as a viable treatment option for GC...
Nuclear export of transmembrane protein PROM2 is specially regulated by CRM1 and affects the sensitivity of ferroptosis in gastric cancer [0.03%]
胃癌中跨膜蛋白PROM2的核输出由CRM1特异性调节并影响铁死亡敏感性
Panpan Zhang,Wenbo Lin,Ting Wu et al.
Panpan Zhang et al.
Background: Gastric cancer (GC) exhibits high mortality and poor prognosis, with ferroptosis playing a critical role in its progression. More recent research suggests that PROM2 are closely associated with MVBs (Multivesi...
Serum TFF2 as a more reliable biomarker for gastric cancer and early gastric cancer: a cross-sectional population-based study [0.03%]
血清TFF2是一种更可靠的胃癌和早期胃癌生物标志物：一项基于人群的横断面研究
Ya Zheng,Zhaofeng Chen,Xiangyi Zan et al.
Ya Zheng et al.
Background: TFF2 is a promising yet underexplored biomarker for gastric cancer. We aimed to investigate the relationship between serum TFF2 and gastric cancer, including early gastric cancer, and its interactions with oth...
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication [0.03%]
幽门螺杆菌根除后胃癌的发病风险与CpG岛高甲基化及低甲基化区域的关系研究
Gota Sudo,Eiichiro Yamamoto,Takeshi Niinuma et al.
Gota Sudo et al.
Background and aim: Aberrant DNA methylation persists in the gastric mucosa after Helicobacter pylori (H. pylori) eradication and may contribute to the development of post-eradication gastric cancer (PEGC). We aimed to co...
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma [0.03%]
术前和/或术后氟尿嘧啶、亚叶酸钙、奥沙利铂和多西他赛的使用对局部晚期食管胃结合部腺癌患者生存的影响
Keiji Sugiyama,Sacheen Kumar,Asif Chaudry et al.
Keiji Sugiyama et al.
Background: Perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is the standard of care for locally advanced oesophagogastric adenocarcinoma (LA-OGA) in Western countries. However, completing treatme...
Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis [0.03%]
亚太地区胃癌腹膜转移后间温和全身治疗共识意见
Zhenggang Zhu,Joji Kitayama,Hyung-Ho Kim et al.
Zhenggang Zhu et al.
Peritoneal metastasis (PM) is a major challenge in advanced gastric cancer (GC) with poor prognosis. Normothermic intraperitoneal and systemic treatment (NIPS) has become a promising therapeutic approach. This consensus aims to provide prac...
Resveratrol targets mitochondrial USP36-SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression [0.03%]
白藜蘊素通過靶向線粒體USP36-SOD2誘導自噬鐵死亡抑制胃癌發展
Xuan Zhao,Sheng Lu,Min Yan et al.
Xuan Zhao et al.
Background: Gastric cancer is an aggressive malignancy with high metastatic potential, limiting effective treatments. Resveratrol, a natural polyphenol, exhibits anti-cancer properties by modulating mitochondrial function...
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study [0.03%]
可切除胃癌手术中皮质类固醇的使用：一项多中心、随机、开放性二期/三期临床试验
Takaomi Hagi,Yukinori Kurokawa,Takeshi Omori et al.
Takaomi Hagi et al.
Background: Excessive surgical stress induces inflammatory cytokine release, negatively impacting prognosis in patients with malignancies. This study aimed to determine whether the anti-inflammatory effect of a corticoste...
An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study [0.03%]
日本真实世界环境中尼伏单抗联合化疗治疗未经治疗的晚期或复发性胃癌疗效和安全性的观察研究：G-KNIGHT研究
Shigenori Kadowaki,Tomoyuki Otsuka,Keiko Minashi et al.
Shigenori Kadowaki et al.
Background: Nivolumab plus chemotherapy has shown efficacy in clinical trials for advanced or recurrent gastric cancer (GC). However, real-world utilization data are limited. In this study, we aimed to assess the effectiv...