Baseline IL-6 independently predicts severe immune-related toxicity and poor survival in advanced gastric cancer treated with immunotherapy [0.03%]
基线IL-6独立预测免疫治疗晚期胃癌患者的严重免疫相关毒性及预后较差
Wanrong Liu,Hui Tang,Ningning Li et al.
Wanrong Liu et al.
Background: Immune checkpoint inhibitors (ICIs) improve survival in advanced gastric cancer (GC), yet predicting therapeutic benefit versus toxicity remains challenging. Elevated interleukin-6 (IL-6) is linked to poor pro...
Correction: IGF2-AS affects the prognosis and metastasis of gastric adenocarcinoma via acting as a ceRNA of miR-503 to regulate SHOX2 [0.03%]
校正：IGF2-AS通过充当miR-503的竞争性内源RNA来调节SHOX2从而影响胃腺癌的预后和转移
Ju Huang,You-Xiang Chen,Bo Zhang
Ju Huang
Correction: Diagnostic discordance and treatment-associated change of PD-L1 and CLDN18.2 in gastric cancer: a real-world analysis of paired biopsy-resection samples [0.03%]
纠正：诊断分歧和治疗相关的胃癌PD-L1和CLDN18.2变化：配对活检-切除样本的现实世界分析
Donghe Yu,Tong Xie,Siyuan Cheng et al.
Donghe Yu et al.
Modified transferrin saturation is associated with postoperative complications in patients undergoing curative gastrectomy for gastric cancer [0.03%]
改良转铁蛋白饱和度与胃癌根治性胃切除术后并发症的相关性研究
Chishou Mitsuura,Satoshi Ida,Hiroki Tsubakihara et al.
Chishou Mitsuura et al.
Background: Surgical complications after gastrectomy significantly impact recovery and long-term prognosis. While iron status influences outcomes, the conventional 20% transferrin saturation (TSAT) threshold ignores sex-s...
Nodal burden modifies the prognostic significance of perineural invasion in stage I-III gastric cancer [0.03%]
淋巴结负担改变I-III期胃癌患者神经周围浸润的预后意义
Qi Wang,Hongxue Meng,Shizheng Xiong et al.
Qi Wang et al.
Background: Perineural invasion (PNI) is an established adverse prognostic factor in gastric cancer, but whether its prognostic effect varies with nodal burden and first metastatic site remains unclear. ...
Multimodal features and prognostic risk assessment in locally advanced gastric cancer patients following neoadjuvant therapy based on machine learning algorithms: a multicenter study [0.03%]
基于机器学习算法的多模态特征在新辅助治疗后局部晚期胃癌患者预后风险评估中的作用：一项多中心研究
Li Liu,Qing Zhong,Caiming Weng et al.
Li Liu et al.
Background: Neoadjuvant therapy (NAT) is recommended for locally advanced gastric cancer (LAGC), but some patients respond poorly. We aimed to construct a multimodal model integrating CT images, transcriptomic sequencing,...
Therapeutic management of resectable mismatch-repair deficient/microsatellite instability-high gastroesophageal adenocarcinoma: a real-world analysis from Austria [0.03%]
奥地利可切除型错配修复缺陷/微卫星不稳定性高的胃食管腺癌治疗管理的现实世界分析
Martin Korpan,Daniel Nothdurfter,Bernhard Doleschal et al.
Martin Korpan et al.
Background: Mismatch-repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastroesophageal adenocarcinoma (GEA) is associated with favorable prognosis but limited benefit from perioperative chemotherapy. Althou...
Loss of EMILIN-1/integrin axis drives microenvironmental reprogramming in gastric tumorigenesis [0.03%]
EMILIN-1/整合素轴丢失驱动胃肿瘤发生过程中微环境重塑
Alessandra Capuano,Maddalena Vescovo,Samanta Muzzin et al.
Alessandra Capuano et al.
Background: EMILIN-1 is an extracellular matrix glycoprotein with tumor-suppressive functions. While its loss is implicated in cancer progression, its specific role in the gastric tumor microenvironment and its clinical r...
Comparison of minimally invasive surgery and open surgery following chemotherapy for cStage IVb gastric cancer: a multicenter retrospective cohort study [0.03%]
可切除的IV期胃癌新辅助化疗后微创手术与开放手术对比的多中心回顾性队列研究
Yusuke Fujii,Shigeo Hisamori,Nobuaki Hoshino et al.
Yusuke Fujii et al.
Background: The standard treatment for stage IV gastric cancer (GC) is chemotherapy, but advances in systemic therapy have rendered curative surgery a viable option. However, the role of minimally invasive surgery (MIS) i...
Komei Kuge,Junko Mukoyama,Yoshimi Yasukawa et al.
Komei Kuge et al.
Background: Serum trefoil factor 3 (TFF3) has emerged as a promising biomarker for gastric cancer; however, its biological origin remains unclear. Methods...