Time-sequential prediction of postoperative complications after gastric cancer surgery using machine learning: a multicenter cohort study [0.03%]
基于机器学习的胃癌手术后并发症时间序列预测：多中心队列研究
Motonari Ri,Souya Nunobe,Tomonori Narita et al.
Motonari Ri et al.
Background: Although many studies have developed logistic regression models for predicting complications using preoperative and intraoperative data, none have applied comprehensive perioperative information with machine l...
Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cells [0.03%]
靶向YES相关蛋白可克服胃肠间质瘤药物耐受性持续肿瘤细胞的伊马替尼耐药性
Takashi Yokouchi,Tsuyoshi Takahashi,Toshirou Nishida et al.
Takashi Yokouchi et al.
Background: The tyrosine kinase inhibitor (TKI) imatinib targets KIT and PDGFRA, offering significant therapeutic benefits in advanced gastrointestinal stromal tumors (GISTs). However, the high rate of recurrence followin...
Development and validation of a machine learning model for predicting immune checkpoint inhibitor efficacy in advanced gastric cancer using dynamic changes in peripheral blood clinlabomics data: a retrospective multicenter cohort study [0.03%]
基于外周血临床组学动态变化的预测晚期胃癌免疫检查点抑制剂疗效的机器学习模型的开发和验证：一项回顾性多中心队列研究
Shulun Nie,Shuyi Song,Qian Xu et al.
Shulun Nie et al.
Background: Immune checkpoint inhibitors (ICIs) play a pivotal role in the treatment of advanced gastric cancer (GC). However, the biomarkers used to predict ICI efficacy are limited due to their reliance on single or sta...
Long-term prognosis of mixed histological-type gastric cancers cured by endoscopic resection: a multicenter prospective cohort study [0.03%]
内镜切除治愈的混合型胃癌长期预后的多中心前瞻性队列研究
Yusuke Horiuchi,Toshiaki Hirasawa,Haruhisa Suzuki et al.
Yusuke Horiuchi et al.
Background: Gastric cancer is divided into differentiated and undifferentiated types and sometimes exhibits mixed histology. However, the risk of gastric cancer-related death after curative endoscopic resection for mixed ...
Early stage gastric cancer with unusual sarcomatous component and no recurrence after endoscopic submucosal dissection: a case report [0.03%]
早期胃癌伴不常见肉瘤样成分内镜下粘膜下剥离术后无复发一例报告
Kohei Shigeta,Yoichi Yamamoto,Tadakazu Shimoda et al.
Kohei Shigeta et al.
Gastric cancer with sarcomatous changes is relatively rare and often detected at an advanced stage. We report the case of an 82-year-old man with early stage gastric cancer exhibiting an unusual morphology with a polypoid growth of a sarcom...
Neoantigen mRNA vaccines induce progenitor-exhausted T cells that support anti-PD-1 therapy in gastric cancer with peritoneal metastasis [0.03%]
新抗原mRNA疫苗诱导前体细胞耗竭T细胞以支持抗PD-1治疗胃癌腹膜转移
Koji Nagaoka,Hideyuki Nakanishi,Hiroki Tanaka et al.
Koji Nagaoka et al.
Background: Gastric cancer with peritoneal metastasis is associated with a poor prognosis. Current treatments, including the first-line therapy of combination chemotherapy with nivolumab for advanced recurrent gastric can...
Predictive value of homologous recombination-related gene mutations in survival outcomes of first-line nivolumab plus chemotherapy for gastric cancer [0.03%]
同源重组相关基因突变对一线纳武利尤单抗联合化疗胃癌患者生存结局的预测价值
Yuna Lee,Hyung-Don Kim,Sun Young Lee et al.
Yuna Lee et al.
Background: Homologous recombination repair (HRR) gene mutations contribute to genomic instability. However, their clinical value in immune checkpoint inhibitor (ICI)-based treatments in gastric cancer remains unclear. Th...
Comparison of clinicopathological features of gastric carcinoma in autoimmune gastritis with and without Helicobacter pylori infection [0.03%]
自身免疫性胃炎伴或不伴有幽门螺杆菌感染的胃癌临床病理特征比较研究
Ayaka Takasu,Toshiaki Hirasawa,Yuka Higashi et al.
Ayaka Takasu et al.
Background: Chronic atrophic gastritis, represented by Helicobacter pylori (H. pylori) or autoimmune gastritis (AIG), has been recognized as a risk factor for gastric carcinoma (GC). Differences in the clinicopathological...
Evaluating peritoneal elastic laminal invasion to improve stratification of patients with pT3 gastric cancer [0.03%]
评估腹膜弹性板层浸润以改善III期胃癌患者的分层治疗
Daiki Terajima,Motohiro Kojima,Shingo Sakashita et al.
Daiki Terajima et al.
Background: Elastic laminal invasion (ELI), defined as tumor invasion beyond the peritoneal elastic lamina, may affect gastric cancer (GC) prognosis, though limited data exist on this relationship. ...