Histone H4K8 lactylation modulated immunosuppressive properties by promoting FAP transcription and ECM remodeling [0.03%]
组蛋白H4K8乳酰化通过促进FAP转录和细胞外基质重塑来调节免疫抑制功能
Chao Huang,Ting Liu,Yuanyuan Zhao et al.
Chao Huang et al.
Background & aims: The role of histone lysine lactylation (Kla) in gastric cancer mesenchymal stromal cells (GCMSCs) remains elusive. This study aimed to investigate the potential lactyltransferase and the influence of hi...
Outcomes of endoscopic submucosal dissection for locally recurrent early gastric cancer after endoscopic resection: analysis of a multicenter prospective cohort study [0.03%]
内镜下切除后早期胃癌局部复发患者内镜粘膜下挖除术治疗结局：一项多中心前瞻性队列研究的分析
Takuma Hiramatsu,Naomi Kakushima,Haruhisa Suzuki et al.
Takuma Hiramatsu et al.
Background: We aimed to reveal the outcomes of endoscopic resection (ER) for locally recurrent early gastric cancer (LRGC) after ER using the data obtained in a Japanese multicenter prospective cohort study of ER for earl...
Impact of prophylactic drain placement on intra-abdominal infections after gastrectomy: nationwide inpatient database study in Japan [0.03%]
预防性引流放置对胃切除术后腹内感染的影响：日本全国住院病人数据库研究
Keita Kouzu,Shotaro Aso,Yuki Hirano et al.
Keita Kouzu et al.
Objective: This study aimed to evaluate the impact of drain placement on the incidence of postoperative complications in patients undergoing gastrectomy. ...
A functional NKILA variant (rs2273534) drives genetic susceptibility and oncogenic progression in gastric cancer via the miR-4424/OAS2 pathway [0.03%]
功能变异NKILA(rs2273534)通过miR-4424/OAS2通路驱动胃癌遗传易感性和恶性进展
Li Hu,Yuan Li,Xinyu Zhao et al.
Li Hu et al.
Objective: This research examines how NF-κB Interacting LncRNA (NKILA) and its functional variant rs2273534 influence gastric cancer (GC) risk, development, and prognosis, along with the molecular pathways involved. ...
Metabolic reprogramming as a key regulator in Helicobacter pylori-infected gastric cancer [0.03%]
代谢重编程在幽门螺旋杆菌感染的胃癌中的关键作用
Ruofan Cao,Feifei Zhou,Cuiyu Zhu et al.
Ruofan Cao et al.
Helicobacter pylori (H. pylori) infection is a recognized risk factor for gastric cancer (GC), which is the leading cause of cancer-related deaths worldwide. As a Class I carcinogen, H. pylori plays a central role in the occurrence and deve...
Exploring the potential of artificial intelligence in assessing the risk of gastric neoplastic lesions in patients with corpus atrophic gastritis [0.03%]
人工智能评估胃体萎缩性胃炎患者胃肿瘤病变风险的潜力分析
Emanuele Dilaghi,Edoardo Cesaroni,Irene Ligato et al.
Emanuele Dilaghi et al.
Background: Corpus atrophic gastritis (CAG) requires endoscopic-histological surveillance due to the risk of developing gastric neoplastic lesions (GNL). This study aimed to identify variables associated with GNL developm...
Burden of gastric cancer attributable to Helicobacter pylori in 27 countries from seven geographic regions in 2022 [0.03%]
27个国家和地区2022年幽门螺杆菌归因胃癌疾病负担七地区的全球估计数值地图
Giulia Collatuzzo,Elton Dajti,Matteo Secco et al.
Giulia Collatuzzo et al.
Background: Helicobacter (H.) pylori is the major risk factor of gastric cancer (GC). We aimed to estimate the population attributable fraction (PAF) of GC and the number of new GC cases and deaths for GC attributable to ...
Clinical impact of gastrectomy in surgically proven stage IV gastric cancers: retrospective analysis from Korean multicenter dataset (PASS-META) [0.03%]
韩国多中心数据库的回顾性分析（PASS-META）：手术证实的IV期胃癌患者的胃切除术临床影响
Ho-Jung Shin,Jeong Ho Song,Sung Eun Kim et al.
Ho-Jung Shin et al.
Background: Palliative resection for metastatic gastric cancer is not recommended in current practice guidelines; however, it is frequently performed based on clinical considerations. Prospective trials face challenges, n...
Helicobacter pylori-naïve status is associated with poor prognosis and aggressive pathological features in undifferentiated-type gastric cancer: a multi-center retrospective cohort study [0.03%]
幽门螺杆菌阴性状态与未分化型胃癌的不良预后和侵袭性病理特征相关：一项基于多中心回顾队列的研究
Yuxuan Ren,Kefang Sun,Hanjin Yang et al.
Yuxuan Ren et al.
Background: Undifferentiated-type gastric cancer (UGC) is more pathologically aggressive and progresses faster than differentiated-type gastric cancer (DGC). However, the impact of Helicobacter pylori (Hp) status on survi...