A Japanese family of hereditary diffuse gastric cancer with a germline pathogenic variant of CTNN1A detected via comprehensive genome profiling [0.03%]
家系基因组全面分析发现CTNN1A遗传性变异的日本弥漫性胃癌家系
Takeshi Kawakami,Hiroyuki Matsubayashi,Yoshimi Kiyozumi et al.
Takeshi Kawakami et al.
CTNNA1 codes α-1 catenin, a molecule that functions in intercellular adhesion in combination with E-cadherin (coded by CDH1). A germline pathogenic variant (GPV) of CTNNA1 increases the risk of hereditary diffuse gastric cancer (HDGC); how...
Minimum resection length to ensure a pathologically negative distal margin and a larger remnant stomach for esophagogastric junction cancer [0.03%]
食管胃交界部癌手术远端切缘阴性最小切除长度及更大残胃的探讨
Qingjiang Hu,Manabu Ohashi,Motonari Ri et al.
Qingjiang Hu et al.
Background: Ensuring a pathologically negative distal margin (DM) and preserving a larger remnant stomach is important for proximal gastrectomy (PG) in patients with esophagogastric junction (EGJ) cancer. However, the min...
Short-term outcomes of preoperative computed tomography angiography versus standard assessment in patients with BMI ≥ 25.0 kg/m2 undergoing laparoscopic gastrectomy: the GISSG20-01 randomized clinical trial [0.03%]
体重≥25.0kg/m²的患者行腹腔镜胃切除术前血管造影与标准评估的近期疗效（GISSG20-01随机临床试验）
Cheng Meng,Shougen Cao,Leping Li et al.
Cheng Meng et al.
Background: Laparoscopic gastrectomy lacks hand-direct tactile sense and has a limited surgical field compared to laparotomy. Apart from textbook classification, there are anatomical variations in the gastric arteries. La...
Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression [0.03%]
欧洲和拉丁美洲胃癌人群的全面病理分析揭示了PDL1、HER2、p53和MUC6表达的差异
Carolina Martínez-Ciarpaglini,Rita Barros,Carmelo Caballero et al.
Carolina Martínez-Ciarpaglini et al.
Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-instit...
Prevalence and clinicopathological features of microsatellite instability-high metastatic or recurrent gastric and esophagogastric junction cancer: WJOG13320GPS [0.03%]
微卫星不稳定高表达胃癌和食管胃交界部癌的流行病学及临床病理特征：WJOG13320GPs研究
Azusa Komori,Shuichi Hironaka,Shigenori Kadowaki et al.
Azusa Komori et al.
Background: Microsatellite instability (MSI)-high tumors represent a distinct, small-fraction subtype in esophagogastric junction cancer or gastric cancer (GC), yet their clinical significance remains poorly understood. T...
Synergistic effects of dihydroartemisinin and cisplatin on inducing ferroptosis in gastric cancer through GPX4 inhibition [0.03%]
二氢青蒿素和顺铂通过抑制GPX4诱导胃癌细胞铁死亡的协同作用
Huina Wang,Chanchan Lu,Haihua Zhou et al.
Huina Wang et al.
Background: In the past several decades, cisplatin (DDP), in combination with other drugs, has been used as the mainstay chemotherapy drug for the treatment of gastric cancer (GC). However, the clinical application of DDP...
Hazard rates of recurrence for gastric cancer after curative resection: implications for postoperative surveillance [0.03%]
胃癌治愈术后复发的风险率及其对术后监测的启示
Kyohei Kanematsu,Yuta Nakayama,Mie Tanabe et al.
Kyohei Kanematsu et al.
Background: Identifying the most effective postoperative surveillance interval in patients with gastric cancer (GC) remains challenging. To elucidate a logical and effective surveillance schedule, we analyzed GC recurrenc...
Tumor infiltration of inactive CD8 + T cells was associated with poor prognosis in Gastric Cancer [0.03%]
无效CD8+t细胞肿瘤浸润与胃癌不良预后相关
Naoki Katayama,Kenoki Ohuchida,Kiwa Son et al.
Naoki Katayama et al.
Background: Gastric cancer (GC) shows limited response to immune checkpoint inhibitors due to its complex tumor immune microenvironment (TIME). This study explores the functions of various immune cells in the complex TIME...
Expression of therapy target molecules in esophagogastric junction and Barrett's adenocarcinoma [0.03%]
食管胃交界部及巴雷特腺癌的治疗靶点分子表达
Hiroyuki Abe,Masayuki Urabe,Koichi Yagi et al.
Hiroyuki Abe et al.
Background: Recently, novel molecular targeted therapies have been developed for gastric and esophageal adenocarcinomas. We examined the status of therapeutic target molecules in esophagogastric junction (EGJ) and Barrett...
Nationwide survey on HER2 and PD-L1 testing practices in gastric cancer across Japan [0.03%]
日本全国胃癌HER2和PD-L1检测实践调查
Hiroyuki Abe,Takeshi Kuwata,Ryoji Kushima et al.
Hiroyuki Abe et al.
Background: Since HER2 and PD-L1 testing are key to selecting drugs for first-line treatments in advanced gastric cancer, evaluating differences in these tests among institutions is necessary to standardize treatment. ...