Development of rapid methodologies for the isolation and quantitation of drug metabolites by differential mobility spectrometry - mass spectrometry [0.03%]
基于差分迁移谱-质谱的药物代谢物快速分离与定量方法学研究
Adam B Hall,Stephen L Coy,Erkinjon Nazarov et al.
Adam B Hall et al.
Clinical and forensic toxicology laboratories are inundated with thousands of samples requiring lengthy chromatographic separations prior to mass spectrometry. Here, we employ differential mobility spectrometry (DMS) interfaced to nano-elec...
Francisco Fernandez-Lima,Desmond A Kaplan,J Suetering et al.
Francisco Fernandez-Lima et al.
In the present work we describe the principles of operation, versatility and applicability of a trapped ion mobility spectrometer (TIMS) analyzer for fast, gas-phase separation of molecular ions based on their size-to-charge ratio. Mobility...
Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics [0.03%]
基于纳喷雾离子源的差移谱作为小型有机物和无机物分析的便携式检测器
Stephen L Coy,Evgeny V Krylov,Erkinjon G Nazarov et al.
Stephen L Coy et al.
Electrospray ionization (ESI) is an important tool in chemical and biochemical survey and targeted analysis in many applications. For chemical detection and identification electrospray is usually used with mass spectrometry (MS). However, f...
Ion Mobility-Mass Correlation Trend Line Separation of Glycoprotein Digests without Deglycosylation [0.03%]
无需脱糖的糖蛋白酶解混合物的离子淌度质谱相关分析法
Hongli Li,Brad Bendiak,William F Siems et al.
Hongli Li et al.
A high-throughput ion mobility mass spectrometer (IMMS) was used to rapidly separate and analyze peptides and glycopeptides derived from glycoproteins. Two glycoproteins, human α-1-acid glycoprotein and antithrombin III were digested with ...
The Influence of Drift Gas Composition on the Separation Mechanism in Traveling Wave Ion Mobility Spectrometry: Insight from Electrodynamic Simulations [0.03%]
漂移气体组成对旅行波离子淌度谱分离机制影响的电动力学模拟研究
Jody C May,John A McLean
Jody C May
The influence of three different drift gases (helium, nitrogen, and argon) on the separation mechanism in traveling wave ion mobility spectrometry is explored through ion trajectory simulations which include considerations for ion diffusion...
Traveling-wave Ion Mobility-Mass Spectrometry Reveals Additional Mechanistic Details in the Stabilization of Protein Complex Ions through Tuned Salt Additives [0.03%]
旅行波离子淌度质谱法揭示了通过调节盐添加剂稳定蛋白复合物离子的额外机制细节
Linjie Han,Brandon T Ruotolo
Linjie Han
Ion mobility-mass spectrometry is often applied to the structural elucidation of multiprotein assemblies in cases where X-ray crystallography or NMR experiments have proved challenging. Such applications are growing steadily as we continue ...
Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages [0.03%]
离子淌度质谱技术在非处方药物和饮料快速分析中的应用
Roberto Fernández-Maestre,Herbert H Hill
Roberto Fernández-Maestre
In the pharmaceutical industry, there are increasing requirements for analytical methods in quality assessment for the production of drugs. In this investigation, ion mobility spectrometry (IMS) was used for the rapid qualitative separation...