STAMBPL1 promotes the progression of gastric cancer via deubiquitinating IQGAP1 to activate the JAK2/STAT3 pathway [0.03%]
STAMBPL1通过去泛素化IQGAP1激活JAK2/STAT3信号通路促进胃癌进展
Xiaocheng Tang,Jun Qiu,Chunyu Chen et al.
Xiaocheng Tang et al.
Background: Gastric cancer (GC) is a highly aggressive malignancy with limited therapeutic options and poor clinical outcomes. Aberrant regulation of the ubiquitin-proteasome system contributes to tumorigenesis by disrupt...
Correction: Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction [0.03%]
订正：关于胰胆合流异常相关胆囊癌HER2/ERBB2扩增及致癌机制的分子见解
Ming Zhu,Daisuke Douchi,Keigo Murakami et al.
Ming Zhu et al.
Published Erratum
Journal of gastroenterology. 2025 Nov 26. DOI:10.1007/s00535-025-02329-6 2025
Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression [0.03%]
胰腺导管内乳头状黏液性肿瘤的分子病理学：目前的认识和恶性进展的展望
Yuki Makino,Kohki Oyama,Akiko Sagara et al.
Yuki Makino et al.
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are bona fide cystic precursor lesions to pancreatic ductal adenocarcinoma (PDAC), which is the cancer type with the most dismal prognosis. Since IPMNs are detectable by imagi...
Deep learning-based mismatch repair prediction using colorectal cancer macroscopic images: a diagnostic study [0.03%]
基于深度学习的利用结直肠癌内镜图像进行mmr状态预测的研究
Zhihan Jiang,Hsinyi Lin,Zimin Zhao et al.
Zhihan Jiang et al.
Background: Mismatch repair (MMR) testing is recommended for all colorectal cancer (CRC) patients, but this assay necessitates the involvement of specialized institutions and is time-consuming. This study aims to develop ...
An endoscopic real-time, in situ assessment of intestinal permeability in type 2 diabetes: links to microbiota and hyperglycemia [0.03%]
2型糖尿病结肠通透性的内镜实时评估：与菌群和高血糖的关系
Yusuke Kimura,Yosuke Minoda,Eikichi Ihara et al.
Yusuke Kimura et al.
Background: Although impaired intestinal barrier function is implicated in type 2 diabetes (T2D), its direct in vivo assessment in humans remains challenging, limiting our understanding of the underlying mechanisms. We ut...
Clinical significance of comprehensive genomic profiling in unresectable or recurrent gastrointestinal stromal tumors: a multicenter retrospective cohort study [0.03%]
不可切除或复发性胃肠道间质瘤的全面基因组谱分析的临床意义：一项多中心回顾性队列研究
Kota Kawabata,Tsuyoshi Takahashi,Hisashi Hara et al.
Kota Kawabata et al.
Background: Tyrosine kinase inhibitors (TKIs) targeting KIT and PDGFRA mutations are the mainstay of treatment for gastrointestinal stromal tumors (GISTs). Comprehensive genomic profiling (CGP) has recently been incorpora...
Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer [0.03%]
带蒂型T1期结直肠癌淋巴结转移、复发和生存的预测因素
Kengo Kasuga,Toshio Uraoka,Yoshiki Kajiwara et al.
Kengo Kasuga et al.
Objectives: The oncologic outcomes of pedunculated-type T1 colorectal cancer (CRC) remain unknown. We determined the risk factors for lymph node metastasis (LNM) and recurrence and evaluated the survival according to the ...
Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan [0.03%]
日本JSCCR数据库中继发性小肠肿瘤的临床病理特征及预后：一项大规模多中心分析
Akiyoshi Tsuboi,Shiro Oka,Takeshi Yamada et al.
Akiyoshi Tsuboi et al.
Background: Owing to the rarity of metastatic tumors in the small bowel, their clinicopathological features, and prognostic factors remain poorly understood. This study aimed to clarify the clinicopathological features an...
Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer [0.03%]
日本慢性胰腺炎患者的死亡率和癌症风险：重视胰腺癌筛查的意义
Ryotaro Matsumoto,Kazuhiro Kikuta,Tetsuya Takikawa et al.
Ryotaro Matsumoto et al.
Background/objective: Since the 2010s, Japan's national health insurance system has covered key management for chronic pancreatitis (CP), including pancreatic enzyme replacement therapy. These therapies are expected to im...
TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice [0.03%]
与TRPV6相关的胰腺炎：自然史及小鼠中特异性胰腺缺失的影响
Atsushi Masamune,Emmanuelle Masson,Wen-Bin Zou et al.
Atsushi Masamune et al.
Background: The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene, encoding a calcium-selective ion channel, was recently identified as a susceptibility gene for pancreatitis. This study aimed ...