Prevalence and incidence of chronic kidney disease in patients with primary biliary cholangitis [0.03%]
原发性胆汁性肝硬化患者慢性肾脏疾病患病率和发病率
Jose Manuel Sousa,Sergio Rodríguez-Tajes,Manuel Hernández-Guerra et al.
Jose Manuel Sousa et al.
Background: Primary biliary cholangitis (PBC) is a liver disease frequently associated with extrahepatic manifestations. Although a relationship with kidney dysfunction has been reported, data about PBC and chronic kidney...
Paired tumor-normal metabolomic profiling reveals alterations in choline phospholipid precursor metabolism in biliary tract cancer [0.03%]
肿瘤-正常配对代谢组学揭示胆道癌中卵磷脂前体代谢物的改变
Hironobu Suto,Kensuke Kumamoto,Mina Nagao et al.
Hironobu Suto et al.
Background: The metabolic landscape of biliary tract cancer (BTC) remains poorly characterized. This study aimed to identify tumor-specific metabolic alterations in BTC using paired tumor and adjacent normal tissues. ...
Methods to build and maintain effective clinician-patient relationships for adults with disorders of gut-brain interaction (DGBI): a systematic review [0.03%]
建立和维持胃肠脑相互作用障碍成人患者的医患关系的策略：系统性回顾研究
Hiroshi Mihara,Juntaro Matsuzaki,Takuya Okugawa et al.
Hiroshi Mihara et al.
Background: The clinician-patient relationship is a vital component of therapeutic success in disorders of gut-brain interaction (DGBI), recently codified as the foundational "Level 1" psychosocial care within the Rome V ...
Comment on: Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease [0.03%]
关于乌司奴单抗、维多利珠单抗和肿瘤坏死因子抑制剂治疗早发型炎症性肠病真实世界结局的评论
Rong Peng,Lingzhen Lin,Chengqian Ye
Rong Peng
Regulatory mechanism of the RNF168-SCCA1-MYH9 signaling axis in the response of ulcerative colitis [0.03%]
RNF168-SCCA1-MYH9信号轴调控溃疡性结肠炎的机制研究
Xuanqi Zhang,Junyan Zhu,Fang Wei et al.
Xuanqi Zhang et al.
Background and aim: The potential function of E3 ubiquitin ligase RNF168 in inflammatory processes remains largely unexplored. Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflam...
The longstanding issue of the benefit of ursodeoxycholic acid in primary sclerosing cholangitis: a long-term population-based study [0.03%]
长期人群研究确定鹅脱氧胆酸治疗原发性硬化性胆管炎益处问题
Bregje Mol,Kim van Munster,Rinse Weersma et al.
Bregje Mol et al.
Background: Although ursodeoxycholic acid (UDCA) is commonly prescribed for primary sclerosing cholangitis (PSC), a beneficial long-term effect on solid clinical endpoints has not yet been established. This study evaluate...
Enis Hikmet Ozmert,Shelby Kohatsu Yee,Sumera Irie Ilyas et al.
Enis Hikmet Ozmert et al.
Perihilar cholangiocarcinoma (pCCA) frequently presents as an indeterminate perihilar biliary stricture. The diagnosis is often delayed or uncertain because of the limited sensitivity of conventional endobiliary sampling and blood-based mar...
Conditional accuracy after lesion preselection: comment on Minakata et al [0.03%]
关于Minakata等人的评论：病灶预选后的条件准确性
Yaohui Liu,Jiang Chen
Yaohui Liu
HOXC9 enhances cholesterol metabolism and malignancy in pancreatic ductal adenocarcinoma through ITGA10/FAK/PI3K/CREB-dependent HMGCR activation [0.03%]
HOXC9通过ITGA10/FAK/PI3K/CREB依赖的HMGCR激活增强胆固醇代谢和恶性肿瘤在胰腺导管腺癌中的作用
Futang Li,Ming Yang,Xinghao Sun et al.
Futang Li et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Dysregulated cholesterol metabolism contributes to tumor progression, but its regulatory mechanisms in PDAC are unclear. This study explored the ro...
SEVs-carried ENPP1 regulates DCs' activation and inhibits the formation of tertiary lymphoid structures in gastric cancer [0.03%]
携带ENPP1的外泌体调节DC激活并抑制胃癌中三级淋巴结构形成
Wenbo Liu,Bingyu Wang,Xinyu Yuan et al.
Wenbo Liu et al.
Background: Ectonucleotide pyrophosphatase/phosphodiesterase 1(ENPP1) is a potential immune checkpoint, but the role and mechanism of small extracellular vesicles (sEVs)-carried ENPP1 in the formation of tertiary lymphoid...