DH-AUTAC induces ferroptosis in colorectal cancer by targeting DHODH for autophagic degradation through KCTD10-SQSTM1 signaling [0.03%]
DH-AUTAC通过KCTD10-SQSTM1信号促进DHODH的自噬降解从而诱导结直肠癌细胞铁死亡
Weibing Wang,Xigang Hu
Weibing Wang
Background: Dihydroorotate dehydrogenase (DHODH) is a critical enzyme involved in pyrimidine biosynthesis anda key suppressor of ferroptosis. This enzyme is commonly overexpressed in colorectal cancer (CRC), and itsupregu...
Clinical course, prognostic markers, and transplant implications in COVID-19-associated secondary sclerosing cholangitis [0.03%]
COVID-19相关继发性硬化性胆管炎的临床过程、预后标志物和移植影响
Johannes Roman Wiessner,Matthias Kis,Daniela Lenggenhager et al.
Johannes Roman Wiessner et al.
Background: Secondary sclerosing cholangitis (SSC) has emerged as a severe complication in critically ill COVID-19 patients. This study outlines the clinical course, prognostic markers, and liver transplantation (LT) outc...
Curcumin blocks Fusobacterium nucleatum-driven tumor progression and carcinogenesis in ESCC via inhibiting the TLR4/MYD88/TRIF/STAT3 axis [0.03%]
姜黄素通过抑制TLR4/MYD88/TRIF/STAT3轴阻断Fusobacterium nucleatum驱动的食管鳞癌进展和致癌作用
Mila Jin,Qiwei Yang,Jiaqi Qin et al.
Mila Jin et al.
Background: The molecular mechanisms by which the epidemiologically linked bacterium Fusobacterium nucleatum (Fn) promotes Esophageal Squamous Cell Carcinoma (ESCC) malignancy are poorly defined. Here, we identify the key...
Cytotoxic immune activity reflects a coordinated immune microenvironment and is associated with response to total neoadjuvant therapy in rectal cancer [0.03%]
细胞毒性免疫活性反映了协调的免疫微环境并与直肠癌新辅助治疗应答相关
Erina Haraguchi,Norio Tanaka,Kentaro Sato et al.
Erina Haraguchi et al.
Background: Total neoadjuvant therapy (TNT) has emerged as a promising treatment strategy for locally advanced rectal cancer; however, robust biomarkers predicting treatment response remain lacking. We aimed to identify p...
Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn's disease [0.03%]
多模态MRI揭示了克罗恩病相关的甘淋巴系统活动与全身炎症和神经精神症状的关系
Yu Yin,Xuehong Wang,Dalian Ou et al.
Yu Yin et al.
Background: While animal studies suggest that intestinal inflammation can remodel glymphatic function, glymphatic alterations in Crohn's disease (CD) remain poorly understood. This study aims to characterize glymphatic ac...
Letter to the editor [0.03%]
致编辑的信
Hassan Iqbal,Zulfiqar Ahmad,Abdur Rehman et al.
Hassan Iqbal et al.
Reply to: comment on "Validation of Baveno VII criteria for recompensation in patients with decompensated cirrhosis treated by laparoscopic splenectomy and azygoportal disconnection" [0.03%]
关于“肝硬化患者经腹腔镜脾切除和离断贲门周围血管离断术后Baveno Ⅶ期标准再代偿验证”的评论回复
Liu-Xin Zhou,Bao-Yu Wan,Hao Dong et al.
Liu-Xin Zhou et al.
rs57494551 increases CXCR5 expression and IgM+ CXCR5+ B-cell infiltration in the portal area of primary biliary cholangitis [0.03%]
rs57494551通过增加CXCR5表达和IgM+CXCR5+B细胞向原发性胆汁性胆管炎门区浸润的危险度来影响疾病发展
Yuki Hitomi,Yoshihiro Aiba,Kazuko Ueno et al.
Yuki Hitomi et al.
Background: Primary biliary cholangitis (PBC) is a chronic, progressive, cholestatic liver disease caused by autoimmune reactions. A previous international meta-analysis of a genome-wide association study (GWAS) reported ...
Natural history of Barrett's esophagus over a 10-year period: a longitudinal endoscopic study in a Japanese population [0.03%]
巴雷特食管10年自然史：日本人群的纵向内镜研究
Kenta Watanabe,Sho Fukuda,Yasutaka Takahashi et al.
Kenta Watanabe et al.
Background: Since Barrett's esophagus (BE) is an established precancerous condition for esophageal adenocarcinoma, understanding the natural history of BE is crucial for effective endoscopic surveillance. We aimed to eluc...
S1P receptor modulators for moderate-to-severe ulcerative colitis: a systematic review, meta-analysis, and trial sequential analysis [0.03%]
中重度溃疡性结肠炎S1P受体调节剂的系统评价、荟萃分析和序贯试验分析
Abdulkareem Jomaa,Rani Bshara,Mohammed Alani et al.
Abdulkareem Jomaa et al.
Background and aims: S1P receptor modulators are emerging oral therapies for moderate-to-severe ulcerative colitis (UC); however, a comprehensive synthesis incorporating the largest number of RCTs to date, alongside Trial...