Matthias Götberg,Jesper van der Pals,Michael Götberg et al.
Matthias Götberg et al.
Two previous clinical trials investigating hypothermia as an adjunct therapy for myocardial infarction have failed. Recently a pilot study has demonstrated a significant reduction in infarct size. The aims of this study were to elucidate th...
Wim Martinet,Dorien M Schrijvers,Guido R Y De Meyer
Wim Martinet
Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely acci...
NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies [0.03%]
丙酮酸脱氢酶在心血管疾病中的作用：来自体内模型和临床研究的启示
Alexander Sirker,Min Zhang,Ajay M Shah
Alexander Sirker
NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of r...
Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [0.03%]
C-反应蛋白单体和五聚体对内皮祖细胞的相反影响
I Ahrens,H Domeij,S U Eisenhardt et al.
I Ahrens et al.
C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation ...
Comparative Study
Basic research in cardiology. 2011 Sep;106(5):879-95. DOI:10.1007/s00395-011-0191-y 2011
Henning Morawietz
Henning Morawietz
Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival [0.03%]
糖原合成酶激酶-3β在血管平滑肌细胞中正向调节Notch信号通路：在细胞增殖和存活中的作用
Shaunta Guha,John P Cullen,David Morrow et al.
Shaunta Guha et al.
The role of glycogen synthase kinase 3 beta (GSK-3β) in modulating Notch control of vascular smooth muscle cell (vSMC) growth (proliferation and apoptosis) was examined in vitro under varying conditions of cyclic strain and validated in vi...
Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis [0.03%]
慢性心脏压力负荷过重会诱发肾上腺髓质肥大和增加儿茶酚胺合成
Johanna Schneider,Achim Lother,Lutz Hein et al.
Johanna Schneider et al.
Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves...
Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? [0.03%]
冠脉旁路移植术前的远端间歇性缺血：减少损伤和炎症的策略吗？
Partheeban Karuppasamy,Sanjay Chaubey,Tracy Dew et al.
Partheeban Karuppasamy et al.
Perioperative myocardial ischemia contributes to postoperative morbidity and mortality. Remote intermittent ischemia (RI) has been shown to benefit patients undergoing coronary artery bypass graft (CABG) surgery by decreasing postoperative ...
Randomized Controlled Trial
Basic research in cardiology. 2011 Jun;106(4):511-9. DOI:10.1007/s00395-011-0185-9 2011
OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway [0.03%]
OxLDL与巨噬细胞存活：Hif通路的本质和非氧依赖性参与作用
David M Poitz,Antje Augstein,Sönke Weinert et al.
David M Poitz et al.
Atherosclerotic plaques are characterized by hypoxic even anoxic areas and by high concentrations of oxidized lipoproteins. Moreover, unstable plaques attract a high number of macrophages despite the proapoptotic background within these pla...