Jasper Iske,Henriette Thau,Joshua M Mesfin et al.
Jasper Iske et al.
Compared to classic myocardial infarction (cMI), myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterized by symptoms consistent with acute coronary syndrome, but without demonstrable coronary obstruction. Ther...
Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting [0.03%]
远程缺血预处理诱导抗血小板聚集预防冠状动脉旁路移植术房颤并发症
Qin Jiang,Yi Zheng,Keli Huang et al.
Qin Jiang et al.
Off-pump coronary artery bypass grafting (OPCABG) is associated with increased platelet aggregation and a higher incidence of postoperative atrial fibrillation (POAF). Remote ischemic preconditioning (RIPC) has been reported as a promising ...
Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy [0.03%]
过氧化物酶体型 catalase 和细胞质型催化酶在巴尔特综合征心肌病中的作用：抗氧化保护机制的研究
Elsie Kajese,Malte Hachmann,Katharina J Ermer et al.
Elsie Kajese et al.
Barth Syndrome (BTHS) is an inherited mitochondrial cardiomyopathy caused by variants in the gene encoding TAFAZZIN (Taz), a transacylase catalyzing the synthesis of the essential mitochondrial phospholipid cardiolipin (CL). Although defect...
Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis [0.03%]
二尖瓣主动脉狭窄的病理特征及其与三尖瓣主动脉狭窄的对比研究
Alexander Brückner,Adrian Brandtner,Sarah Rieck et al.
Alexander Brückner et al.
Calcific aortic valve stenosis is the most common valvular heart disease requiring treatment. Although both tricuspid (AVS) and bicuspid (bAVS) aortic valve stenoses become calcified and functionally impaired in advanced stages, the pathoph...
Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium [0.03%]
Aficamten的作用机制是通过增加健康的鼠和犬心肌的舒张期室腔容积并保持心输出量来实现依赖长度的力量生成的保存
Fruzsina Sárkány,Dániel Priksz,Béla Juhász et al.
Fruzsina Sárkány et al.
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction (H...
Functional rejuvenation of endothelial cell aging by transient reprogramming [0.03%]
血管内皮细胞衰老的瞬时重编程再生活化作用
Katrin Kalies,Kai Knoepp,Laura Hehl et al.
Katrin Kalies et al.
Senescent endothelial cells (ECs), characterized by a reduced angiogenic and regenerative potential, are key players in the pathophysiology of cardiovascular diseases. Therefore, targeting these cells has been suggested as an effective ther...
Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction [0.03%]
心肌梗死后冠状内皮细胞发生以静脉为主的紊乱成熟现象
Kaitlyn Ford,Hosanna Abbay,Amy S Leonardson et al.
Kaitlyn Ford et al.
The coronary microvascular plexus responds to cardiac ischemia through angiogenic neovascularization in the ischemic and border zones to sustain the demand for oxygen and nutrients. Although new blood vessels form, the process of endothelia...
Fernanda Brognara,Jaci Airton Castania,Mirele Resende Machado et al.
Fernanda Brognara et al.
Neuroimmune communication is essential for regulating inflammation and maintaining cardiovascular homeostasis, but the role of sensory pathways in this process is poorly understood. Arterial baroreceptors are typically defined as mechanorec...
Dissecting myocardial and systemic drivers of cardiac dysfunction in the murine CVB3 myocarditis model using microRNA-guided viral detargeting [0.03%]
采用microRNA引导的病毒再靶向方法剖析小鼠CVB3心肌炎模型中心肌和系统性功能障碍的驱动因素
Sarah Ochs,Sandra Pinkert,Sophia Borowski et al.
Sarah Ochs et al.
In murine coxsackievirus B3 myocarditis, the most widely used experimental model of viral myocarditis, functional alterations such as reduced cardiac output are frequently interpreted as surrogates of myocardial injury and inflammation, des...
Renal denervation in experimental autoimmune myocarditis: association with cardiac function and changes in calcium and MAPK/ERK signaling [0.03%]
肾去神经支配在实验性自身免疫性心肌炎中的作用：与心脏功能和钙及MAPK/ERK信号转导改变的关系研究
Ya-Wen Hsiao,Wei-Lun Lin,Yu-Hui Chou et al.
Ya-Wen Hsiao et al.
Renal denervation (RDN) has emerged as a potential therapeutic strategy to modulate autonomic imbalance and attenuate inflammation in cardiovascular disease. However, the mechanisms underlying its cardioprotective effects remain incompletel...