Renal denervation in experimental autoimmune myocarditis: association with cardiac function and changes in calcium and MAPK/ERK signaling [0.03%]
肾去神经支配在实验性自身免疫性心肌炎中的作用：与心脏功能和钙及MAPK/ERK信号转导改变的关系研究
Ya-Wen Hsiao,Wei-Lun Lin,Yu-Hui Chou et al.
Ya-Wen Hsiao et al.
Renal denervation (RDN) has emerged as a potential therapeutic strategy to modulate autonomic imbalance and attenuate inflammation in cardiovascular disease. However, the mechanisms underlying its cardioprotective effects remain incompletel...
Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression [0.03%]
恩格列净可恢复肥胖糖尿病HFpEF小鼠的心功能但进一步改变基因表达
Juliana Mira Hernandez,Logan R J Bailey,Victoria R Salemme et al.
Juliana Mira Hernandez et al.
Effective treatments for heart failure with preserved ejection fraction (HFpEF) are limited. Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, provides cardiovascular benefits for patients with HFpEF. SGLT2 expression is vi...
Functional consequences of diminished myocardial oxygen delivery per beat in experimental heart failure [0.03%]
实验性心力衰竭中心肌每次心跳氧气递送减少的功能后果
Salman I Essajee,Matthew J Eden,Victoria E Sturgess et al.
Salman I Essajee et al.
This investigation was designed to test the hypothesis that heart failure (HF) attenuates coronary vasodilation and autoregulation and that deficits in contractile function are proportionally related to reductions in the volume of myocardia...
Toll-like receptor 7 constrains efferocytosis in myocardial injury [0.03%]
toll-like受体7在心肌损伤中限制efferocytosis的作用
Yanqiu Lai,Suet Yen Chong,Vaarsha Nair et al.
Yanqiu Lai et al.
Toll-like receptor 7 (TLR7) is an endosomal sensor of single-stranded RNA that is highly expressed in macrophages and contributes to post-infarct inflammation. Whether TLR7 also restrains macrophage reparative function, particularly efferoc...
Dose-dependent effects and mechanisms of exercise-like stimulation on cardiac injury and contractile function: outcomes of the MICRO-ATHLETE study [0.03%]
运动刺激对心脏损伤和收缩功能剂量依赖性效应及机制：MICRO-ATHLETE研究结果
Tom T J Luiken,Carla Cofiño-Fabres,José M Rivera-Arbeláez et al.
Tom T J Luiken et al.
Observational studies revealed that exercise produces cardiac troponin release and cardiac fatigue in athletes. However, human in vivo studies offer limited insights into the underlying mechanisms of these potential deleterious effects. Thi...
Activation of the C3a-C3aReceptor-axis is associated with endothelial dysfunction and glycocalyx damage in ST-elevation myocardial infarction [0.03%]
C3a-C3a受体轴活化与ST段抬高型心肌梗死患者的内皮功能障碍和糖萼损伤相关性研究
Carl Vahldieck,Samuel Löning,Constantin Hamacher et al.
Carl Vahldieck et al.
Complement activation is an early event in ischemia-reperfusion injury during ST-elevation myocardial infarction (STEMI) and drives endothelial dysfunction via glycocalyx (eGC) degradation. While downstream fragments such as C5a contribute ...
Publisher Correction: The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes [0.03%]
出版更正：CNP类似物vosoritide介导了STZ诱导的1型糖尿病小鼠心脏中的PDE2敏感的抗心律失常效应
Rebecca Firneburg,Katharina Tergau,Eleder Cachorro et al.
Rebecca Firneburg et al.
Published Erratum
Basic research in cardiology. 2026 Apr 27. DOI:10.1007/s00395-026-01175-8 2026
Deubiquitinase USP43 exacerbates myocardial ischemia-reperfusion injury by stabilizing ASK1 and activating the JNK/P38 MAPK pathway [0.03%]
去泛素化酶USP43通过稳定ASK1并激活JNK/p38丝裂原活化蛋白激酶通路来加重心肌缺血再灌注损伤
Wei Sun,Hongjie Shi,Guowei Fu et al.
Wei Sun et al.
Myocardial ischemia-reperfusion injury (MIRI) remains a major challenge in reperfusion therapy for acute myocardial infarction. The role of deubiquitinating enzyme ubiquitin-specific protease 43 (USP43) in this process, however, remains lar...
Analyzing the role of ATP-dependent potassium channels in the regulation of coronary metabolic vasodilation during exercise [0.03%]
分析ATP依赖性钾通道在运动时冠状代谢血管舒张调节中的作用
Salman I Essajee,Cooper M Warne,Johnathan D Tune et al.
Salman I Essajee et al.
The purpose of this meta-analysis is to compile, integrate, and assess studies that have investigated the role of ATP-dependent potassium channels (KATP channels) in coronary metabolic vasodilation in vivo. KATP channels are important modul...
Empagliflozin improves metabolism and prevents myocardial and coronary dysfunction in streptozotocin-diabetic and non-diabetic rats subjected to ischemia/reperfusion [0.03%]
恩格列净改善代谢并预防链脲佐菌素糖尿病和非糖尿病大鼠缺血/再灌注引起的心肌和冠状动脉功能障碍
Carmine Rocca,Anna De Bartolo,Maria Concetta Granieri et al.
Carmine Rocca et al.
Diabetes heightens cardiovascular risk. The selective sodium-glucose cotransporter 2 inhibitor empagliflozin (EMPA) shows cardiovascular benefits in heart failure, type 2 diabetes and chronic kidney disease. While EMPA protects against myoc...