Chemokine-receptor-guided B-cell immunity in cardiovascular disease [0.03%]
趋化因子受体指导的B细胞免疫在心血管疾病中的作用
Anais Yerly,Emiel P C van der Vorst,Marc Schindewolf et al.
Anais Yerly et al.
Cardiovascular diseases (CVD) include a wide range of disorders affecting the heart and blood vessels, many of which are associated with atherosclerosis. Atherosclerosis is the main underlying cause of CVDs and represents a chronic inflamma...
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes [0.03%]
CNP类似物vosoritide介导了在链脲佐菌素诱导的1型糖尿病小鼠心脏中的PDE2敏感的抗心律失常效应
Rebecca Firneburg,Katharina Tergau,Eleder Cachorro et al.
Rebecca Firneburg et al.
Diabetes mellitus induces adverse structural, electrophysiological and autonomic remodelling increasing the risk for life-threatening arrhythmias, particularly after acute myocardial infarction. Natriuretic peptides (NPs) show increasing ev...
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure [0.03%]
TCF19和ATAD2表达下调导致心脏肥大向心力衰竭进展过程中心肌内皮细胞周期阻滞
Elias Erny,Christoph Koentges,Debanjan Mukherjee et al.
Elias Erny et al.
Cardiac hypertrophy is a key mechanism that allows the heart to adapt to increased load, but in the long term is associated with a higher risk for heart failure, arrhythmia, and death. During hypertrophic growth, cardiac myocytes signal to ...
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis [0.03%]
肾去神经支配通过抑制ATP-P2X7-NLRP3炎性小体轴缓解HFpEF心脏功能障碍
Zhuqing Li,Xiaoqiang Sun,Yanxin Wang et al.
Zhuqing Li et al.
Heart failure with preserved ejection fraction (HFpEF) arises from intersecting comorbidities involving inflammation, metabolic stress, and sympathetic nervous system (SNS) activation. To mirror this complexity, we established a clinically ...
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis [0.03%]
NLRP3介导脂质驱动的动脉粥样硬化中成熟巨噬细胞增殖
Carmen Härdtner,Felix Remmersmann,Carolin Ehlert et al.
Carmen Härdtner et al.
An increased number of macrophages in the atherosclerotic plaque is associated with plaque instability and plaque progression. Lowering systemic cholesterol levels suppresses local macrophage proliferation and leads to plaque regression. Ho...
Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy [0.03%]
心脏钠葡萄糖共转运蛋白1(SGLT1)参与糖尿病心肌病小鼠模型中心力衰竭的发展
Zhao Li,Sydney Freiberg,Meredith L Music et al.
Zhao Li et al.
Diabetes mellitus can lead to a cardiomyopathy independent of other risk factors such as coronary artery disease and hypertension, in up to 75% of patients. The prevalence of diabetic cardiomyopathy in the population is 1.1%. We previously ...
Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk [0.03%]
钙化主动脉瓣疾病通过细胞通讯增强囊泡miR-145-5p来调节瓣膜间质细胞的钙化
P R Goody,D Christmann,D Goody et al.
P R Goody et al.
Calcific aortic valve disease (CAVD) is one of the leading causes of cardiovascular death in the elderly population worldwide. MicroRNAs (miRNAs) are highly dysregulated in patients with CAVD undergoing surgical aortic valve replacement (SA...
Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation [0.03%]
α-酮戊二酸通过FTO介导的抗炎巨噬细胞活化来预防心肌梗死
Zhijun Lin,Huan He,Pinliang Chen et al.
Zhijun Lin et al.
Ischemic heart disease lacks optimal therapies targeting post-infarction inflammation and remodeling. The role of TCA cycle metabolites in modulating macrophage-driven cardiac inflammation remains unclear. This study hypothesized that AKG s...
The influence of acute and chronic coronary syndrome on the gut microbiome and downstream microbiome-derived metabolites-Microbiome in acute myocardial infarction-MIAMI-Trial [0.03%]
急性及慢性冠状动脉综合征对肠道微生物群及其下游代谢产物的影响-急性心肌梗死中的微生物组：MIAMI试验
Daniel Messiha,Erik Lange,Annika Tratnik et al.
Daniel Messiha et al.
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the industrialized world. The gut microbiome influences CVD, through atherogenic metabolites like trimethylamine N-oxide (TMAO) or protective effects through ...
Benedikt Bartsch,Raúl Nicolas Jamin,Axel Schott et al.
Benedikt Bartsch et al.
Infective endocarditis (IE) is a highly lethal disease with a notable male predominance, yet the biological basis for this sex disparity remains unclear. We established a murine IE model in C57BL6 mice in which aortic valve injury was induc...