Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization [0.03%]
I类清道夫受体通过抑制M1型巨噬细胞极化减轻心肌梗死后心肌细胞坏死
Yulong Hu,Hanwen Zhang,Yan Lu et al.
Yulong Hu et al.
Classically (M1) and alternatively (M2) activated macrophage subsets play differential roles in left ventricular remodeling after myocardial infarction (MI). The precise mechanism underlying the regulation of M1/M2 polarization during MI is...
Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy [0.03%]
肥厚型心肌病中野生型和突变型β-肌球蛋白的等位基因非对称表达
Snigdha Tripathi,Imke Schultz,Edgar Becker et al.
Snigdha Tripathi et al.
Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease, which in about 30% of the patients is caused by missense mutations in one allele of the β-myosin heavy chain (β-MHC) gene (MYH7). To address potential molecular ...
Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness [0.03%]
2型糖尿病(db/db)小鼠的冠状动脉发生与血管僵硬度降低相关的特有的重塑模式
Paige S Katz,Aaron J Trask,Flavia M Souza-Smith et al.
Paige S Katz et al.
Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling in type 2 diabetic (db/db) mice...
Therapeutic neovascularization for coronary disease: current state and future prospects [0.03%]
冠状动脉疾病治疗性新生血管化现状及前景展望
Antonio D Lassaletta,Louis M Chu,Frank W Sellke
Antonio D Lassaletta
Despite advances in surgical and percutaneous revascularization techniques, nearly one-third of patients with ischemic coronary artery disease are not candidates for revascularization due to suboptimal anatomy or receive suboptimal revascul...
Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways [0.03%]
热损伤诱导的心肌细胞凋亡依赖survivin并通过PI3K/Akt，p38 MAPK和ERK通路调控
Wei Cao,Yan-Hua Xie,Xiao-Qiang Li et al.
Wei Cao et al.
Survivin belongs to the family of genes known as inhibitors of apoptosis, and although it has been implicated in the prevention of cancer, its potential role in burn-induced cardiac injury is unknown. In this study, we investigated the effe...
Perfusion defect size predicts engraftment but not early retention of intra-myocardially injected cardiosphere-derived cells after acute myocardial infarction [0.03%]
心肌梗死后心肌内注射心脏球体衍生细胞的植入和早期保留与灌注缺陷大小的关系
Riikka Lautamäki,John Terrovitis,Michael Bonios et al.
Riikka Lautamäki et al.
Therapeutic cell retention and engraftment are critical for myocardial regeneration. Underlying mechanisms, including the role of tissue perfusion, are not well understood. In Wistar Kyoto rats, syngeneic cardiosphere-derived cells (CDCs) w...
Tumor necrosis factor receptor 2 signaling limits β-adrenergic receptor-mediated cardiac hypertrophy in vivo [0.03%]
肿瘤坏死因子受体2信号转导限制了β-肾上腺素能受体介导的体内心脏肥大作用
Jason B Garlie,Tariq Hamid,Yan Gu et al.
Jason B Garlie et al.
The in vivo role of TNF signaling in the genesis of β-adrenergic receptor (β-AR)-mediated cardiac hypertrophy is unknown. Wild-type (WT), TNF receptor 1 (TNFR1)-/- and TNFR2-/- mice were given isoproterenol (ISO, 12.5 μg/kg/h) or saline ...
Circulating microparticles: new insights into the biochemical basis of microparticle release and activity [0.03%]
循环微颗粒：关于微颗粒释放和功能的生化基础的新见解
Silvia Montoro-García,Eduard Shantsila,Francisco Marín et al.
Silvia Montoro-García et al.
Circulating microparticles released from various cell types are present in healthy individuals and the number and composition of their membrane vary in different disorders. Long considered to be cellular debris, microparticles have been rec...
Remodeling of inward rectifying K(+) currents in rat atrial myocytes by overexpression of A(1)-adenosine receptors [0.03%]
A1腺苷受体过表达对大鼠心房肌细胞内向整流钾电流的改建作用
M-C Kienitz,C Littwitz,K Bender et al.
M-C Kienitz et al.
In rat atrial myocytes GIRK (Kir3) channels can be activated by acetylcholine and adenosine via M(2) and A(1) receptors coupled to Pertussis-toxin-sensitive G proteins, such as M(2)R or A(1)R. Owing to the lower density of A(1)R, the amplit...
Does mild hypothermia protect against reperfusion injury? The debate continues [0.03%]
轻度低温可以预防再灌注损伤吗？讨论仍在继续
Renaud Tissier,Michael V Cohen,James M Downey
Renaud Tissier
Mild hypothermia (32-35°C) salvages ischemic myocardium and reduces infarct size in hearts undergoing ischemia/reperfusion. It is clear that a cardioprotective effect is evident when the heart is cooled during ischemia, and the protection ...