Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study [0.03%]
凋亡外周血细胞释放的胞外囊泡可通过抑制心肌重构对急性心梗后的心肌细胞提供细胞保护：一项动物实验研究
Michael Lichtenauer,Michael Mildner,Konrad Hoetzenecker et al.
Michael Lichtenauer et al.
Heart failure following acute myocardial infarction (AMI) is a major cause of morbidity and mortality. Our previous observation that injection of apoptotic peripheral blood mononuclear cell (PBMC) suspensions was able to restore long-term c...
Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction [0.03%]
内皮祖细胞的存在与急性心肌梗死患者的微血管阻塞减少、梗死面积减小和左室重构受限有关
Nicolas Meneveau,Frédéric Deschaseaux,Marie-France Séronde et al.
Nicolas Meneveau et al.
Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing mic...
Estradiol inhibits hyaluronic acid synthase 1 expression in human vascular smooth muscle cells [0.03%]
雌二醇通过抑制人血管平滑肌细胞透明质酸合酶1的表达发挥抗动脉粥样硬化作用
Till Freudenberger,Katharina Röck,Guang Dai et al.
Till Freudenberger et al.
Epidemiological and clinical data suggest that estrogen retards the progression of atherosclerosis. This study aims to elucidate whether the phenotypic regulation of human vascular smooth muscle cells (VSMC) by estrogen may involve effects ...
K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca(2+) release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes [0.03%]
K201（JTV-519）改变β肾上腺素刺激下大鼠心室肌细胞舒张期钙离子释放的时间和空间特性以及相关的舒张收缩
E B Elliott,H Hasumi,N Otani et al.
E B Elliott et al.
K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stim...
Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction [0.03%]
间充质基质细胞在急性心肌梗死后介导单核/巨噬细胞向另类活化方向转化
Victor Dayan,Gustavo Yannarelli,Filio Billia et al.
Victor Dayan et al.
Given the established anti-inflammatory properties of mesenchymal stromal cells (MSCs), we investigated their effect on inflammatory cell infiltration of ischemic cardiac tissue and cardiac function. We employed two types of MSCs, human bon...
Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy [0.03%]
慢性Akt激活加重了衰老诱导的心脏肥大和心肌收缩功能障碍：自噬的作用
Yinan Hua,Yingmei Zhang,Asli F Ceylan-Isik et al.
Yinan Hua et al.
Aging is often accompanied with geometric and functional changes in the heart, although the underlying mechanisms remain unclear. Recent evidence has described a potential role of Akt and autophagy in aging-associated organ deterioration. T...
NF-κB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure [0.03%]
心力衰竭中室旁核NF-κB调节神经递质及交感神经过度兴奋的产生
Yu-Ming Kang,Feng Gao,Hui-Hua Li et al.
Yu-Ming Kang et al.
Findings from our laboratory indicate that proinflammatory cytokines and their transcription factor, nuclear factor-kappaB (NF-κB), are increased in the hypothalamic paraventricular nucleus (PVN) and contribute towards the progression of h...
The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury [0.03%]
抗糖尿病药物对心肌缺血再灌注损伤的潜在影响
Yumei Ye,Jose R Perez-Polo,David Aguilar et al.
Yumei Ye et al.
Heart disease and stroke account for 65% of the deaths in people with diabetes mellitus (DM). DM and hyperglycemia cause systemic inflammation, endothelial dysfunction, a hypercoagulable state with impaired fibrinolysis and increased platel...
EphB signaling inhibits gap junctional intercellular communication and synchronized contraction in cultured cardiomyocytes [0.03%]
EphB信号抑制培养的心肌细胞的缝隙连接通讯和同步收缩
Maki Ishii,Itsuki Mueller,Takayuki Nakajima et al.
Maki Ishii et al.
Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with important roles not only in development but also in the physiology of many adult organs. However, their cellular localization and functions in the my...
Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle [0.03%]
慢性跑台运动诱导的线粒体生物合成及PGC-1α脱乙酰化：心脏和骨骼肌中的不同反应
Ling Li,Christian Mühlfeld,Bernd Niemann et al.
Ling Li et al.
Posttranslational modifications of the transcriptional coactivator PGC-1α by the deacetylase SIRT1 and the kinase AMPK are involved in exercise-induced mitochondrial biogenesis in skeletal muscle. However, similar investigations have not b...