Regulatory T cells ameliorate cardiac remodeling after myocardial infarction [0.03%]
调节性T细胞可减轻心肌梗死后的心室重构
Ting-Ting Tang,Jing Yuan,Zheng-Feng Zhu et al.
Ting-Ting Tang et al.
Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remo...
Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients [0.03%]
DPP4活性丧失与内皮细胞促凝血状态有关：心肌梗塞患者冠状微血管的含义
Paul A J Krijnen,Nynke E Hahn,Ivana Kholová et al.
Paul A J Krijnen et al.
Pro-coagulant and pro-inflammatory intramyocardial (micro)vasculature plays an important role in acute myocardial infarction (AMI). Currently, inhibition of serine protease dipeptidyl peptidase 4 (DPP4) receives a lot of interest as an anti...
Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR [0.03%]
慢性运动调节RAS组分及改善SHR脑内炎症因子失衡效应
Deepmala Agarwal,Michael A Welsch,Jeffrey N Keller et al.
Deepmala Agarwal et al.
Recently, exercise has been recommended as a part of lifestyle modification for all hypertensive patients; however, the precise mechanisms of its effects on hypertension are largely unknown. Therefore, this study aimed to investigate the me...
G-CSF therapy reduces myocardial repolarization reserve in the presence of increased arteriogenesis, angiogenesis and connexin 43 expression in an experimental model of pacing-induced heart failure [0.03%]
G-CSF治疗通过增加动脉发生、新生血管形成和缝隙连接蛋白43表达减少实验性心动过速诱导的心力衰竭心脏的 myocardial repolarization reserve
Peter Milberg,Rainer Klocke,Gerrit Frommeyer et al.
Peter Milberg et al.
G-CSF (granulocyte colony-stimulating factor) treatment has been shown to cause beneficial effects including a reduction of inducible arrhythmias in rodent models of ischemic cardiomyopathy. The aim of the present study was to test whether ...
Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach [0.03%]
心肌梗死后猪心脏左室重构的转录本研究方法
Diederik W D Kuster,Daphne Merkus,Andreas Kremer et al.
Diederik W D Kuster et al.
Despite the apparent appropriateness of left ventricular (LV) remodeling following myocardial infarction (MI), it poses an independent risk factor for development of heart failure. There is a paucity of studies into the molecular mechanisms...
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart [0.03%]
心脏成纤维细胞活化和细胞外基质重塑的关键调节因子环核苷酸磷酸二酯酶1A
Clint L Miller,Yujun Cai,Masayoshi Oikawa et al.
Clint L Miller et al.
Cardiac fibroblasts become activated and differentiate to smooth muscle-like myofibroblasts in response to hypertension and myocardial infarction (MI), resulting in extracellular matrix (ECM) remodeling, scar formation and impaired cardiac ...
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection [0.03%]
一种新的线粒体鞘氨醇-1-磷酸的作用：心肌保护过程中由鞘氨醇激酶-2介导的PTP依赖性细胞存活作用
Ludovic Gomez,Melanie Paillard,Megan Price et al.
Ludovic Gomez et al.
Although mitochondria are key determinants of myocardial injury during ischemia-reperfusion (I/R), their interaction with critical cytoprotective signaling systems is not fully understood. Sphingosine-1-phosphate (S1P) produced by sphingosi...
Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress [0.03%]
伊伐布雷定减慢心率在两种内皮功能障碍和氧化应激模型中的不同效果
Swenja Kröller-Schön,Eberhard Schulz,Philip Wenzel et al.
Swenja Kröller-Schön et al.
Heart rate reduction with the I(f)-channel-inhibitor ivabradine is a novel and appealing option in the therapy of patients with ischemic heart disease. The aim of the current study was to determine the effects of ivabradine in two different...
The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia [0.03%]
线粒体渗透性转变在再灌注诱导的心肌细胞死亡中的作用取决于缺血的持续时间
Marisol Ruiz-Meana,Javier Inserte,Celia Fernandez-Sanz et al.
Marisol Ruiz-Meana et al.
Mitochondrial permeability transition (MPT) is critical in cardiomyocyte death during reperfusion but it is not the only mechanism responsible for cell injury. The objectives of the study is to investigate the role of the duration of myocar...
Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-β (TRIF) in the adult mouse heart is protective in acute viral myocarditis [0.03%]
Toll受体抵抗域所含诱导干扰素β的转化表达对急性病毒性心肌炎具有保护作用
Zhaohui Xu,Moreshwar Desai,Joseph Philip et al.
Zhaohui Xu et al.
TIR-domain-containing adaptor-inducing interferon-β (TRIF) plays a major role in Toll-like receptor 3 (TLR3) mediated signaling. Mice deficient in TLR3 and TRIF have been shown to be highly susceptible to enterovirus-induced myocardial inj...